AB169748

Anti-FGF1 alpha antibody

Name: Anti-FGF1 alpha antibody (ab169748) | Abcam
Brand: Abcam Limited
SKU: AB169748

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(5 Publications)

Mouse Polyclonal FGF1 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human FGF1.

View Alternative Names

FGFA, FGF1, Fibroblast growth factor 1, FGF-1, Acidic fibroblast growth factor, Endothelial cell growth factor, Heparin-binding growth factor 1, aFGF, ECGF, HBGF-1

1 Images

Immunocytochemistry/ Immunofluorescence - Anti-FGF1 alpha antibody (AB169748)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-FGF1 alpha antibody (AB169748)

Immunocytochemistry/Immunofluorescence analysis of HeLa cells labeling FGF1 alpha with ab169748 at 10μg/ml.

Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

WB, ICC/IF

applications

Immunogen

Recombinant Full Length Protein corresponding to Human FGF1.

P05230

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "10 µg/mL", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Chicken": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Hamster": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Orangutan": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Pig": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Sheep": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

pH: 7.4 Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

FGF1 alpha also known as fibroblast growth factor 1 or aFGF functions as an important mediator in cellular processes such as proliferation differentiation and angiogenesis. This protein with a mass of approximately 18 kDa binds to specific fibroblast growth factor receptors (FGFRs) and heparan sulfate proteoglycans to initiate signal transduction. FGF1 alpha expresses in various tissues including brain liver and heart and plays significant roles in development and tissue repair.

Biological function summary

FGF1 alpha facilitates critical cellular functions by promoting cellular growth and survival. It often associates with other members of the fibroblast growth factor family and signaling molecules to form complexes essential for signal cascade initiation. This protein supports cellular resilience under stress conditions and participates in a variety of cellular activities which include wound healing and neovascularization.

Pathways

FGF1 alpha plays a significant role in the MAPK/ERK and PI3K/Akt signaling pathways. These pathways are fundamental for regulating cell cycle progression apoptosis and metabolic stability. FGF1 alpha interacts with proteins like FGF2 and FGFR1 which are involved in transmitting signals from the cell membrane to the nucleus impacting gene expression and cellular response.

FGF1 alpha is associated with cancer and metabolic disorders such as obesity-related insulin resistance. Its dysregulation or aberrant expression may result in uncontrolled cell growth typical of tumorigenic processes. FGF1 alpha often relates to FGF2 in oncogenic pathways where both proteins contribute to angiogenesis and tumor growth indicating their potential targets in therapeutic strategies for cancer treatment.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV : ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed : 18441324, PubMed : 20422052). Can induce angiogenesis (PubMed : 23469107).

See full target information FGF1

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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 14:344 PubMed36670126

2023

Sensory nerve niche regulates mesenchymal stem cell homeostasis via FGF/mTOR/autophagy axis.

Applications

Unspecified application

Species

Unspecified reactive species

Fei Pei,Li Ma,Junjun Jing,Jifan Feng,Yuan Yuan,Tingwei Guo,Xia Han,Thach-Vu Ho,Jie Lei,Jinzhi He,Mingyi Zhang,Jian-Fu Chen,Yang Chai

Frontiers in cell and developmental biology 9:693694 PubMed34195203

2021

Hypoxia Response Element-Directed Expression of aFGF in Neural Stem Cells Promotes the Recovery of Spinal Cord Injury and Attenuates SCI-Induced Apoptosis.

Applications

Unspecified application

Species

Unspecified reactive species

Yibo Ying,Yifan Zhang,Yurong Tu,Min Chen,Zhiyang Huang,Weiyang Ying,Qiuji Wu,Jiahui Ye,Ziyue Xiang,Xiangyang Wang,Zhouguang Wang,Sipin Zhu

Cell death & disease 12:107 PubMed33479232

2021

Acidic fibroblast growth factor attenuates type 2 diabetes-induced demyelination via suppressing oxidative stress damage.

Applications

Unspecified application

Species

Unspecified reactive species

Rui Li,Beini Wang,Chengbiao Wu,Duohui Li,Yanqing Wu,Libing Ye,Luxia Ye,Xiongjian Chen,Peifeng Li,Yuan Yuan,Hongyu Zhang,Ling Xie,Xiaokun Li,Jian Xiao,Jian Wang

Scientific reports 10:2939 PubMed32076044

2020

Activated FGF2 signaling pathway in tumor vasculature is essential for acquired resistance to anti-VEGF therapy.

Applications

Unspecified application

Species

Unspecified reactive species

Kenji Ichikawa,Saori Watanabe Miyano,Yukinori Minoshima,Junji Matsui,Yasuhiro Funahashi

Molecular medicine reports 18:1025-1030 PubMed29845277

2018

Acid fibroblast growth factor facilitates the progression of atherosclerotic plaques regardless of alterations in serum lipid expression levels in HFD‑fed ApoE‑/‑ mice.

Applications

Unspecified application

Species

Unspecified reactive species

Jibo Han,Yao Du,Lintao Wang,Xiong Chen,Liqin Jiang,Jianjiang Xu

View all publications

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Product promise

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Anti-FGF1 alpha antibody

Immunocytochemistry/ Immunofluorescence - Anti-FGF1 alpha antibody (AB169748)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Complementary Products

Assay Kits

Reagents, Controls & Accessories

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (5)

Product promise