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AB9588

Anti-FGF1 antibody

5

(2 Reviews)

|

(15 Publications)

Rabbit Polyclonal FGF1 antibody. Suitable for ELISA, WB, sELISA, ICC/IF, IHC-Fr and reacts with Human, Rat, Recombinant full length protein - Human samples. Cited in 15 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human FGF1.

View Alternative Names

FGFA, FGF1, Fibroblast growth factor 1, FGF-1, Acidic fibroblast growth factor, Endothelial cell growth factor, Heparin-binding growth factor 1, aFGF, ECGF, HBGF-1

1 Images
Sandwich ELISA - Anti-FGF1 antibody (AB9588)
  • sELISA

Supplier Data

Sandwich ELISA - Anti-FGF1 antibody (AB9588)

ab9588 detecting FGF-1 in sELISA

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Light chain type

unknown

Carrier free

No

Reacts with

Human, Rat

Applications

sELISA, ELISA, ICC/IF, WB, IHC-Fr

applications

Immunogen

Recombinant Full Length Protein corresponding to Human FGF1.

P05230

Reactivity data

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Product details

This product is no longer batch tested in IHC, for an IHC validated antibody please see ab179455

Properties and storage information

Form
Lyophilized
Reconstitution
Reconstitute with 200µl of sterile water.
Purification technique
Affinity purification Immunogen
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

FGF1 also known as acidic fibroblast growth factor (aFGF) is a member of the fibroblast growth factor family. This protein has a molecular mass of approximately 17 kDa. FGF1 is expressed in a variety of tissues such as the brain liver and heart and plays an essential role in cell growth development and repair. The FGF1 protein is sometimes studied using techniques such as FGF1 ELISA which helps in quantifying and understanding its expression levels and activity in different contexts.
Biological function summary

FGF1 is involved in numerous cellular processes beyond simple cell proliferation. It binds to fibroblast growth factor receptors (FGFRs) on the cell surface initiating a cascade of downstream signaling events. This protein does not act alone; it is often a part of larger protein complexes that modulate cellular processes such as angiogenesis and wound healing. FGF1 is also implicated in nerve cell differentiation and survival through FGFR-mediated pathways.

Pathways

The FGF1 protein is integrally involved in the MAPK/ERK signaling pathway a critical pathway that regulates cell division growth and differentiation. Through this pathway FGF1 interacts with various proteins including Ras Raf and ERK to propagate the signal necessary for mitogenic and survival responses. FGF1 is also a player in the phosphoinositide 3-kinase (PI3K) pathway which helps control cellular responses to stress and metabolic regulation showing its role in cellular homeostasis.

FGF1 is associated with conditions such as cancer and cardiovascular diseases. The deregulation of FGF1 expression or its signaling pathways can lead to tumor development and progression with FGF1 often interacting with other proteins like the basic fibroblast growth factor (bFGF) in these contexts. In cardiovascular diseases altered FGF1 signaling might contribute to atherosclerosis and cardiac repair processes where its interaction with other growth factors like vascular endothelial growth factor (VEGF) is significant.

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Target data

Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV : ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed : 18441324, PubMed : 20422052). Can induce angiogenesis (PubMed : 23469107).
See full target information FGF1

Publications (15)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 15:9667 PubMed39516487

2024

FNDC4 alleviates cardiac ischemia/reperfusion injury through facilitating HIF1α-dependent cardiomyocyte survival and angiogenesis in male mice.

Applications

Unspecified application

Species

Unspecified reactive species

Xin Zhang,Yi-Peng Gao,Wen-Sheng Dong,Kang Li,Yu-Xin Hu,Yun-Jia Ye,Can Hu

Cells 11: PubMed35954241

2022

FGF10 Therapeutic Administration Promotes Mobilization of Injury-Activated Alveolar Progenitors in a Mouse Fibrosis Model.

Applications

Unspecified application

Species

Unspecified reactive species

Yu-Qing Lv,Ge-Fu Cai,Ping-Ping Zeng,Qhaweni Dhlamini,Le-Fu Chen,Jun-Jie Chen,Han-Deng Lyu,Majid Mossahebi-Mohammadi,Negah Ahmadvand,Saverio Bellusci,Xiaokun Li,Chengshui Chen,Jin-San Zhang

Hepatology communications 6:1574-1588 PubMed35271760

2022

FGF1 Signaling Modulates Biliary Injury and Liver Fibrosis in the Mdr2 Mouse Model of Primary Sclerosing Cholangitis.

Applications

Unspecified application

Species

Unspecified reactive species

April O'Brien,Tianhao Zhou,Tori White,Abigail Medford,Lixian Chen,Konstantina Kyritsi,Nan Wu,Jonathan Childs,Danaleigh Stiles,Ludovica Ceci,Sanjukta Chakraborty,Burcin Ekser,Leonardo Baiocchi,Guido Carpino,Eugenio Gaudio,Chaodong Wu,Lindsey Kennedy,Heather Francis,Gianfranco Alpini,Shannon Glaser

Anatomia, histologia, embryologia 50:645-657 PubMed33772852

2021

The distribution and immunolocalization of fibroblast growth factors (FGFs) in the rat oviduct during early pregnancy and the post-partum period.

Applications

Unspecified application

Species

Unspecified reactive species

Emel Alan,Narin Liman

Medical science monitor : international medical jo 26:e924394 PubMed33020467

2020

miR-188-3p Inhibits Vascular Smooth Muscle Cell Proliferation and Migration by Targeting Fibroblast Growth Factor 1 (FGF1).

Applications

Unspecified application

Species

Unspecified reactive species

Shaohua Mi,Pengfei Wang,Lejun Lin

QJM : monthly journal of the Association of Physicians 113:859-869 PubMed32176291

2020

Morphine post-conditioning-induced up-regulation of lncRNA TINCR protects cardiomyocytes from ischemia-reperfusion injury via inhibiting degradation and ubiquitination of FGF1.

Applications

Unspecified application

Species

Unspecified reactive species

M Wang,S Liu,H Wang,R Tang,Z Chen

Clinical cancer research : an official journal of 25:7202-7217 PubMed31515463

2019

Adaptive Resistance to Dual BRAF/MEK Inhibition in BRAF-Driven Tumors through Autocrine FGFR Pathway Activation.

Applications

Unspecified application

Species

Unspecified reactive species

Victoria E Wang,Jenny Y Xue,Dennie T Frederick,Yi Cao,Eva Lin,Catherine Wilson,Anatoly Urisman,David P Carbone,Keith T Flaherty,Rene Bernards,Piro Lito,Jeff Settleman,Frank McCormick

Journal of cellular biochemistry 120:19087-19097 PubMed31264280

2019

LncRNA TUG1 regulates FGF1 to enhance endothelial differentiation of adipose-derived stem cells by sponging miR-143.

Applications

Unspecified application

Species

Unspecified reactive species

Ya-Nan Xue,Yu Yan,Zi-Zi Chen,Jia Chen,Feng-Jie Tang,Hui-Qing Xie,Shi-Jie Tang,Ke Cao,Xiao Zhou,Ai-Jun Wang,Jian-Da Zhou

Journal of cellular and molecular medicine 23:4422-4433 PubMed30993882

2019

miRNA-210-3p regulates trophoblast proliferation and invasiveness through fibroblast growth factor 1 in selective intrauterine growth restriction.

Applications

Unspecified application

Species

Unspecified reactive species

Lin Li,Xuan Huang,Zhiming He,Yuanyan Xiong,Qun Fang

International journal of cancer 144:322-333 PubMed30110127

2018

Extracellular vesicles from human liver stem cells inhibit tumor angiogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Tatiana Lopatina,Cristina Grange,Valentina Fonsato,Marta Tapparo,Alessia Brossa,Sofia Fallo,Adriana Pitino,Maria Beatriz Herrera-Sanchez,Sharad Kholia,Giovanni Camussi,Benedetta Bussolati
View all publications

Product promise

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