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AB227102

Anti-FGF10 antibody

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(3 Publications)

Rabbit Polyclonal FGF10 antibody. Suitable for WB and reacts with Rat, Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human FGF10.

View Alternative Names

Fibroblast growth factor 10, FGF-10, Keratinocyte growth factor 2, FGF10

2 Images
Western blot - Anti-FGF10 antibody (AB227102)
  • WB

Supplier Data

Western blot - Anti-FGF10 antibody (AB227102)

All lanes:

Western blot - Anti-FGF10 antibody (ab227102) at 1/5000 dilution

All lanes:

HUVEC (human umbilical vein endothelial cell line) whole cell lysate at 15 µg

Predicted band size: 23 kDa

false

Western blot - Anti-FGF10 antibody (AB227102)
  • WB

Supplier Data

Western blot - Anti-FGF10 antibody (AB227102)

12% SDS-PAGE gel.

All lanes:

Western blot - Anti-FGF10 antibody (ab227102) at 1/1000 dilution

All lanes:

Rat2 whole cell extract at 30 µg

Predicted band size: 23 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Rat, Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human FGF10. The exact immunogen used to generate this antibody is proprietary information.

O15520

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Alternative Products

Primary Antibodies

AB83439

Biotin Anti-FGF10 antibody

  • 0
  • 0
Primary Antibodies

AB115825

Anti-FGF10 antibody

Western blot - Anti-FGF10 antibody (AB115825)

  • 0
  • 0

Complementary Products

Proteins & Peptides

AB218104

Recombinant human FGF10 protein (Active)

Bioactive

Functional Studies - Recombinant human FGF10 protein (Active) (AB218104)

  • 0
  • 0
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB289968

Anti-FGFR2 antibody [EPR24075-418]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant|KO Validated|Trial Size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FGFR2 antibody [EPR24075-418] (AB289968)

  • 3
  • 1
Primary Antibodies

AB133600

Anti-CBFb antibody [EPR6322]

RabMAb|Recombinant|KO Validated

Immunocytochemistry/ Immunofluorescence - Anti-CBFb antibody [EPR6322] (AB133600)

  • 0
  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/10000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/10000", "WB-species-notes": "<p></p>" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rhesus monkey": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Sheep": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

FGF10 also known as fibroblast growth factor 10 (FGF-10) is a member of the FGF family. It plays an important role in various developmental processes. It is a protein with a molecular mass of approximately 23 kDa. FGF10 is expressed in several tissues including the lungs limbs and salivary glands. Peprotech and recombinant versions of the FGF-10 protein are often utilized in research. In addition to its standard expression FGF10 is sometimes referenced in the context of biotin sublingual preparations which are used to study signaling processes more effectively.
Biological function summary

The FGF10 protein participates in important signaling necessary for embryonic development and tissue repair. It functions as a signaling molecule mediating interaction between epithelial and mesenchymal cells. FGF10 acts as a ligand for fibroblast growth factor receptor 2 (FGFR2) and is essential for limb bud formation and lung epithelium branching morphogenesis. This protein often works without forming part of a larger complex instead interacting with receptors directly to accomplish its functions.

Pathways

Fibroblast growth factor 10 is an integral part of the FGFR signaling pathway which is vital for cell proliferation differentiation and survival. Its interaction with FGFR2 activates downstream signaling cascades including the MAPK/ERK pathway. This involves related proteins such as FGFR1 and Ras important for transmitting extracellular signals to the nuclear environment affecting gene expression patterns essential for development and cell maintenance.

FGF10 has significant implications in pathologies such as lacrimo-auriculo-dento-digital (LADD) syndrome and congenital lung diseases. Mutations or dysregulation in FGF10 expression can lead to developmental abnormalities in the organs it helps form. LADD syndrome showcases its interplay with FGFR2 where mutations in FGF10 or its receptor are implicated in congenital features. Additionally abnormalities in its signaling can contribute to improper lung development where FGF10 again interacts prominently with proteins related to the FGFR family emphasizing its role in proper organogenesis.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing.
See full target information FGF10
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Experimental and therapeutic medicine 22:795 PubMed34093751

2021

miR-9 alleviated the inflammatory response and apoptosis in caerulein-induced acute pancreatitis by regulating FGF10 and the NF-κB signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Yang Shen,Chengjun Xue,Guoli You,Cui Liu

Oncology reports 44:2656-2668 PubMed33125133

2020

Role and mechanism of FLNa and UCP2 in the development of cervical cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Aihong Wang,Lu Liu,Miao Yuan,Sai Han,Xuewu You,Hui Zhang,Fuhua Lei,Youzhong Zhang

PloS one 15:e0239151 PubMed32941516

2020

Estrogen improves the development of yak (Bos grunniens) oocytes by targeting cumulus expansion and levels of oocyte-secreted factors during in vitro maturation.

Applications

Unspecified application

Species

Unspecified reactive species

Yangyang Pan,Meng Wang,Libin Wang,Qian Zhang,Abdul Rasheed Baloch,Honghong He,Gengquan Xu,Jamila Soomro,Yan Cui,Sijiu Yu
View all publications
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Product promise

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