Anti-FGF11 antibody [MM0282-6J20]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

FGF11 also known as Fibroblast Growth Factor 11 is a member of the FGF family specifically part of the intracellular FGF subfamily that does not exhibit heparin-binding activity. This protein weighs approximately 25 kDa. FGF11 is expressed in the nervous system particularly in the developing and adult brain with notable expression in the cerebral cortex hippocampus and cerebellum. Unlike many other FGFs FGF11 is not secreted and functions intracellularly making it unique in its mechanical role compared to its family members.

Biological function summary

FGF11 contributes to the regulation of neuronal development and function. It is not part of a well-characterized protein complex but it plays a role in stabilizing voltage-gated sodium channels influencing synaptic transmission and neuronal excitability. FGF11 acts at intracellular sites to modulate electrophysiological properties of neurons further supporting the critical roles neurons perform in processing information and maintaining neurological functions.

Pathways

Research shows that FGF11 indirectly influences the signaling pathways involved in neurodevelopment and neuroplasticity. It does not partake directly in the traditional FGF receptor-initiated signaling cascades but interacts with intracellular proteins like ion channels affecting the function of pathways linked to neuronal electrical activity. Additionally FGF11's interaction with proteins such as neuronal sodium channels highlights its indirect influence on neurotrophic signaling pathways overlapping with pathways involving other intracellular FGFs.

Associated diseases and disorders

FGF11 has connections to neurodegenerative conditions and epilepsy. Its role in modulating neuronal excitability links it to disorders where electrical activity in the brain is dysregulated such as epilepsy. Research also shows an association with proteins like SCN1A and SCN2A which are involved in similar pathways and have implications in epilepsy. Understanding FGF11's expression and function provides insights into its potential as a therapeutic target for certain neurological disorders.