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AB89713

Anti-FGF11 antibody [MM0282-6J20]

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(3 Publications)

Mouse Monoclonal FGF11 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human FGF11.

View Alternative Names

FHF3, FGF11, Fibroblast growth factor 11, FGF-11, Fibroblast growth factor homologous factor 3, FHF-3

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FGF11 antibody [MM0282-6J20] (AB89713)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FGF11 antibody [MM0282-6J20] (AB89713)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human placental tissue section (4μm) labelling FGF11 with ab89713. Tissue was treated with 15μg/ml Protenase K for antigen retrieval and fixed with 4% PFA. A HRP-conjugated anti-mouse IgG was used as the secondary antibody (30 minutes at room temperature) followed by DAB color development.

Western blot - Anti-FGF11 antibody [MM0282-6J20] (AB89713)
  • WB

Supplier Data

Western blot - Anti-FGF11 antibody [MM0282-6J20] (AB89713)

All lanes:

Western blot - Anti-FGF11 antibody [MM0282-6J20] (ab89713) at 1/500 dilution

All lanes:

Human placenta tissue lysate

Predicted band size: 25 kDa

Observed band size: 25 kDa

false

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

MM0282-6J20

Isotype

IgG2

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Full Length Protein corresponding to Human FGF11.

Q92914

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" } } }
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Product details

produced from a hybridoma
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
The IgG fraction of culture supernatant was purified by Protein G affinity chromatography and 0.2 µm filtered.
Storage buffer
Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

FGF11 also known as Fibroblast Growth Factor 11 is a member of the FGF family specifically part of the intracellular FGF subfamily that does not exhibit heparin-binding activity. This protein weighs approximately 25 kDa. FGF11 is expressed in the nervous system particularly in the developing and adult brain with notable expression in the cerebral cortex hippocampus and cerebellum. Unlike many other FGFs FGF11 is not secreted and functions intracellularly making it unique in its mechanical role compared to its family members.
Biological function summary

FGF11 contributes to the regulation of neuronal development and function. It is not part of a well-characterized protein complex but it plays a role in stabilizing voltage-gated sodium channels influencing synaptic transmission and neuronal excitability. FGF11 acts at intracellular sites to modulate electrophysiological properties of neurons further supporting the critical roles neurons perform in processing information and maintaining neurological functions.

Pathways

Research shows that FGF11 indirectly influences the signaling pathways involved in neurodevelopment and neuroplasticity. It does not partake directly in the traditional FGF receptor-initiated signaling cascades but interacts with intracellular proteins like ion channels affecting the function of pathways linked to neuronal electrical activity. Additionally FGF11's interaction with proteins such as neuronal sodium channels highlights its indirect influence on neurotrophic signaling pathways overlapping with pathways involving other intracellular FGFs.

FGF11 has connections to neurodegenerative conditions and epilepsy. Its role in modulating neuronal excitability links it to disorders where electrical activity in the brain is dysregulated such as epilepsy. Research also shows an association with proteins like SCN1A and SCN2A which are involved in similar pathways and have implications in epilepsy. Understanding FGF11's expression and function provides insights into its potential as a therapeutic target for certain neurological disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Probably involved in nervous system development and function.
See full target information FGF11
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Discover oncology 15:606 PubMed39480592

2024

LINC00342 regulates the PI3K-AKT signaling pathway via the miR-149-5p/FGF11 axis and affects the progression of oral cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Yimiao Chen,Yanchun Wang,Wenbo Zhang

Cancer management and research 15:753-763 PubMed37525667

2023

Fibroblast Growth Factor 11 (FGF11) Promotes Progression and Cisplatin Resistance Through the HIF-1α/FGF11 Signaling Axis in Ovarian Clear Cell Carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Min Yin,Chunli Lu,Huimei Zhou,Qian Liu,Jiaxin Yang

Journal of translational medicine 19:353 PubMed34404435

2021

Fibroblast growth factor 11 (FGF11) promotes non-small cell lung cancer (NSCLC) progression by regulating hypoxia signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaowei Wu,Minjie Li,Ying Li,Yu Deng,Shun Ke,Fan Li,Yujin Wang,Shuchang Zhou
View all publications
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Product promise

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