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AB221892

Anti-FGF12 antibody

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(1 Publication)

Rabbit Polyclonal FGF12 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human FGF12 aa 200 to C-terminus.

View Alternative Names

FGF12B, FHF1, FGF12, Fibroblast growth factor 12, FGF-12, Fibroblast growth factor homologous factor 1, Myocyte-activating factor, FHF-1

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-FGF12 antibody (AB221892)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-FGF12 antibody (AB221892)

PFA-fixed, Triton X-100 permeabilized U-2 OS (human bone osteosarcoma epithelial cell line) cells stained for FGF12 (green) using ab221892 at 4 μg/ml in ICC/IF.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human FGF12 aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P61328

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" }, "Mouse": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

FGF12 also known as fibroblast growth factor 12 is a member of the fibroblast growth factor family and has a molecular mass of approximately 28 kDa. FGF12 is expressed in various human tissues notably in the brain and heart where it plays an essential role in cellular processes. Unlike many other FGF family members FGF12 does not have a heparin-binding domain. This distinction affects its interaction with local extracellular matrices and influences how it functions within cells.
Biological function summary

Fibroblast growth factors regulate cell differentiation growth and tissue repair. Though not a typical secreted growth factor FGF12 functions intracellularly where it contributes to neuronal signaling. FGF12 interacts with ion channels and proteins in the central nervous system suggesting its role in modifying electrical signaling pathways. It does not typically form part of a large complex but it associates with proteins that mediate such signaling functions.

Pathways

FGF12 plays a significant role in the intracellular signaling pathways especially those related to neurogenesis and cardiac conduction. In these pathways FGF12 regulates ion channel activity ensuring proper signal propagation. It connects with related pathways of other fibroblast growth factors such as FGF11 sharing key similarities in modulating electrophysiological properties within excitable cells like neurons and cardiomyocytes.

FGF12 has links to cardiac arrhythmias and epilepsy. Alterations in FGF12 expression can disrupt normal cardiac and neural electrical activity hinting at its involvement in these conditions. It interacts with several ion channels such as the sodium channel subunit SCN5A which can result in clinical manifestations when dysregulated. Understanding FGF12's role provides insights into potential therapeutic targets for managing arrhythmias and seizure disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Involved in nervous system development and function. Involved in the positive regulation of voltage-gated sodium channel activity. Promotes neuronal excitability by elevating the voltage dependence of neuronal sodium channel SCN8A fast inactivation.
See full target information FGF12
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Biology of reproduction 100:561-572 PubMed30295753

2018

Murine PAIP1 stimulates translation of spermiogenic mRNAs stored by YBX2 via its interaction with YBX2†.

Applications

Unspecified application

Species

Unspecified reactive species

Yue He,Yu Lin,Yu Zhu,Ping Ping,Guishuan Wang,Fei Sun
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Product promise

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