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AB187982

Anti-FGF17 antibody

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(2 Publications)

Rabbit Polyclonal FGF17 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human FGF17 aa 1-100.

View Alternative Names

UNQ161/PRO187, FGF17, Fibroblast growth factor 17, FGF-17

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FGF17 antibody (AB187982)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FGF17 antibody (AB187982)

Immunohistochemical analysis of paraffin-embedded Human testis tissue labeling FGF17 with ab187982 at 1/50 dilution.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human FGF17 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.

O60258

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Fibroblast Growth Factor 17 (FGF17) is a member of the fibroblast growth factor family and is also known as FGF-17. This protein has a molecular mass of approximately 22 kDa. You may find FGF17 expressed in various tissues including the brain particularly in the cerebellum where it plays significant roles in development. The protein functions as a signaling molecule engaging with fibroblast growth factor receptors (FGFRs) to initiate a cascade of cellular events.
Biological function summary

FGF17 influences processes such as cell proliferation differentiation and neural development. It often operates as part of a larger fibroblast growth factor signaling complex that includes other growth factors and their receptors. This complex formation is essential for the fine-tuning of signal transduction events. By interacting with multiple FGFRs FGF17 contributes to the regulation of embryonic development and tissue regeneration.

Pathways

FGF17 is a part of the MAPK/ERK signaling pathway which plays a significant role in transmitting signals from surface receptors to the DNA in the nucleus. This pathway engages with other proteins such as FGFR1 and FGFR2 facilitating processes like cell growth and division. FGF17 also participates in the PI3K/AKT pathway which is important for cell survival and metabolism indicating its broad impact on important cellular functions.

FGF17 has connections to skeletal disorders such as craniosynostosis a condition where the bones of the skull fuse prematurely. Mutations or dysregulation in FGF17 expression can contribute to this disorder. Additionally FGF17 alterations have an association with cancers including prostate cancer where increased expression leads to uncontrolled cell growth. FGF17 interacts with proteins such as FGFR2 in these contexts illustrating its role in pathological development.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Plays an important role in the regulation of embryonic development and as signaling molecule in the induction and patterning of the embryonic brain. Required for normal brain development.
See full target information FGF17
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in molecular biosciences 8:794326 PubMed35155566

2022

Metastatic Immune-Related Genes for Affecting Prognosis and Immune Response in Renal Clear Cell Carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Si Sun,Weipu Mao,Lilin Wan,Kehao Pan,Liting Deng,Lei Zhang,Guangyuan Zhang,Ming Chen

The Journal of neuroscience : the official journal 39:1386-1404 PubMed30617207

2019

Heparan Sulfate Sulfation by Hs2st Restricts Astroglial Precursor Somal Translocation in Developing Mouse Forebrain by a Non-Cell-Autonomous Mechanism.

Applications

Unspecified application

Species

Unspecified reactive species

James M Clegg,Hannah M Parkin,John O Mason,Thomas Pratt
View all publications
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