Anti-FGF17 antibody [MM0284-5H27]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Fibroblast Growth Factor 17 (FGF17) is a member of the fibroblast growth factor family and is also known as FGF-17. This protein has a molecular mass of approximately 22 kDa. You may find FGF17 expressed in various tissues including the brain particularly in the cerebellum where it plays significant roles in development. The protein functions as a signaling molecule engaging with fibroblast growth factor receptors (FGFRs) to initiate a cascade of cellular events.

Biological function summary

FGF17 influences processes such as cell proliferation differentiation and neural development. It often operates as part of a larger fibroblast growth factor signaling complex that includes other growth factors and their receptors. This complex formation is essential for the fine-tuning of signal transduction events. By interacting with multiple FGFRs FGF17 contributes to the regulation of embryonic development and tissue regeneration.

Pathways

FGF17 is a part of the MAPK/ERK signaling pathway which plays a significant role in transmitting signals from surface receptors to the DNA in the nucleus. This pathway engages with other proteins such as FGFR1 and FGFR2 facilitating processes like cell growth and division. FGF17 also participates in the PI3K/AKT pathway which is important for cell survival and metabolism indicating its broad impact on important cellular functions.

Associated diseases and disorders

FGF17 has connections to skeletal disorders such as craniosynostosis a condition where the bones of the skull fuse prematurely. Mutations or dysregulation in FGF17 expression can contribute to this disorder. Additionally FGF17 alterations have an association with cancers including prostate cancer where increased expression leads to uncontrolled cell growth. FGF17 interacts with proteins such as FGFR2 in these contexts illustrating its role in pathological development.