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AB169615

Anti-FGF18 antibody

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(4 Publications)

Mouse Polyclonal FGF18 antibody. Suitable for WB and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human FGF18.

View Alternative Names

UNQ420/PRO856, FGF18, Fibroblast growth factor 18, FGF-18, zFGF5

1 Images
Western blot - Anti-FGF18 antibody (AB169615)
  • WB

Unknown

Western blot - Anti-FGF18 antibody (AB169615)

All lanes:

Western blot - Anti-FGF18 antibody (ab169615) at 1/1 dilution

Lane 1:

FGF18 transfected 293T cell lysate at 15 µL

Lane 2:

Non-transfected 293T cell lysate at 15 µL

Predicted band size: 24 kDa

false

Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human FGF18.

O76093

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Primary Antibodies

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Anti-PD-L1 antibody [28-8]

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Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
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Primary Antibodies

AB273118

Anti-Eph receptor A2 antibody [EPR24711-11]

20ul selling size|RabMAb|Recombinant|KO Validated|Trial Size

Western blot - Anti-Eph receptor A2 antibody [EPR24711-11] (AB273118)

  • 0
  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Chimpanzee": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

FGF18 also known as fibroblast growth factor 18 has important mechanical functions in the body. It is a member of the fibroblast growth factor family and weighs around 19 kDa. FGF18 appears mostly in tissues like cartilage and bone with significant expression in the brain. This protein helps send signals that guide cell growth differentiation and tissue repair.
Biological function summary

FGF18 performs key roles in developmental processes such as skeletal development and chondrogenesis. It interacts with receptors like FGFR3 as part of signaling complexes to regulate these processes. FGF18 influences the proliferation and differentiation of chondrocytes cells that produce and maintain cartilage which is critical for bone growth and regeneration.

Pathways

FGF18 is an integral player in the fibroblast growth factor signaling pathway and is involved in the MAPK pathway. These pathways impact cell division and growth where FGF18 activates the FGF receptors particularly FGFR1 and FGFR3. This interaction results in mitogenic and cell survival activities contributing to normal growth and development in tissues.

FGF18 has associations with conditions like osteoarthritis and achondroplasia. In osteoarthritis abnormal FGF18 signaling can lead to disrupted cartilage homeostasis affecting FGFR3. In achondroplasia mutations in FGFR3 alter FGF18-related pathways resulting in impaired bone growth. Understanding these connections helps guide therapeutic strategies that target FGF18 signaling in these diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Plays an important role in the regulation of cell proliferation, cell differentiation and cell migration. Required for normal ossification and bone development. Stimulates hepatic and intestinal proliferation.
See full target information FGF18
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

American journal of translational research 13:8728-8741 PubMed34539990

2021

miR-590-5p affects chondrocyte proliferation, apoptosis, and inflammation by targeting FGF18 in osteoarthritis.

Applications

Unspecified application

Species

Unspecified reactive species

Peng Jiang,Xixi Dou,Shuaiguang Li,Qingwen Jia,Peixue Ling,Hongyu Liu,Qiuju Han,Shui Sun

Frontiers in immunology 11:557184 PubMed33193326

2020

CD206+ M2-Like Macrophages Are Essential for Successful Implantation.

Applications

Unspecified application

Species

Unspecified reactive species

Yosuke Ono,Osamu Yoshino,Takehiro Hiraoka,Erina Sato,Yamato Fukui,Akemi Ushijima,Allah Nawaz,Yasushi Hirota,Shinichiro Wada,Kazuyuki Tobe,Akitoshi Nakashima,Yutaka Osuga,Shigeru Saito

Oncology reports 40:704-714 PubMed29901199

2018

Fibroblast growth factor 18 promotes the growth, migration and invasion of MDA‑MB‑231 cells.

Applications

Unspecified application

Species

Unspecified reactive species

Ziyi Yu,Longquan Lou,Yi Zhao

Cellular and molecular life sciences : CMLS 74:4561-4572 PubMed28726057

2017

Macrophage migration inhibitory factor (MIF) modulates trophic signaling through interaction with serine protease HTRA1.

Applications

ICC

Species

Mouse

Åsa Fex Svenningsen,Svenja Löring,Anna Lahn Sørensen,Ha Uyen Buu Huynh,Simone Hjæresen,Nellie Martin,Jesper Bonnet Moeller,Maria Louise Elkjær,Uffe Holmskov,Zsolt Illes,Malin Andersson,Solveig Beck Nielsen,Eirikur Benedikz
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

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