Anti-FGF18 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

FGF18 also known as fibroblast growth factor 18 has important mechanical functions in the body. It is a member of the fibroblast growth factor family and weighs around 19 kDa. FGF18 appears mostly in tissues like cartilage and bone with significant expression in the brain. This protein helps send signals that guide cell growth differentiation and tissue repair.

Biological function summary

FGF18 performs key roles in developmental processes such as skeletal development and chondrogenesis. It interacts with receptors like FGFR3 as part of signaling complexes to regulate these processes. FGF18 influences the proliferation and differentiation of chondrocytes cells that produce and maintain cartilage which is critical for bone growth and regeneration.

Pathways

FGF18 is an integral player in the fibroblast growth factor signaling pathway and is involved in the MAPK pathway. These pathways impact cell division and growth where FGF18 activates the FGF receptors particularly FGFR1 and FGFR3. This interaction results in mitogenic and cell survival activities contributing to normal growth and development in tissues.

Associated diseases and disorders

FGF18 has associations with conditions like osteoarthritis and achondroplasia. In osteoarthritis abnormal FGF18 signaling can lead to disrupted cartilage homeostasis affecting FGFR3. In achondroplasia mutations in FGFR3 alter FGF18-related pathways resulting in impaired bone growth. Understanding these connections helps guide therapeutic strategies that target FGF18 signaling in these diseases.