Rabbit Polyclonal FGF20 antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human FGF20.
Images
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.05% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human FGF20. The exact immunogen used to generate this antibody is proprietary information. Database link Q9NP95
Reactivity data
Select an application| IHC-P | |
|---|---|
| Human | Tested |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/25.00000 - 1/100.00000 | Notes - |
Target data
Function
Neurotrophic factor that regulates central nervous development and function.
Alternative names
Fibroblast growth factor 20, FGF-20, FGF20
Recommended products
Rabbit Polyclonal FGF20 antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human FGF20.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.05% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human FGF20. The exact immunogen used to generate this antibody is proprietary information. Database link Q9NP95
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
FGF20 also known as Fibroblast Growth Factor 20 plays a role in cell proliferation and differentiation. This protein weighs approximately 22 kDa and is secreted into the extracellular space. FGF20 is mainly expressed in the brain with significant levels observed in the substantia nigra region. The protein is also found in other tissues like the heart and kidneys although at lower concentrations.
- Biological function summary
FGF20 functions in neurodevelopment and tissue repair. It is not part of a complex but interacts directly with fibroblast growth factor receptors (FGFRs) mostly FGFR1 and FGFR3. These receptors facilitate its role in promoting the growth and survival of specific neuronal cells. FGF20 also aids in the maintenance of dopaminergic neurons which are important for motor control processes.
- Pathways
FGF20 is an active participant in the PI3K-Akt signaling pathway and the MAPK/ERK pathway. These pathways are important for regulating cell growth survival and differentiation. FGF20 interacts with other proteins like AKT1 and MAPK1 therefore influencing various developmental processes. Its signaling activities help ensure that cells respond appropriately to external growth signals.
- Associated diseases and disorders
FGF20 has a significant link to Parkinson's disease and cancer. In Parkinson's disease the reduction of FGF20 can lead to decreased protection of dopaminergic neurons potentially worsening the condition. Similarly in certain cancer types the aberrant signaling of FGF20 contributes to tumor growth and progression. The protein interacts with FGFR1 in these contexts emphasizing its regulatory importance in disease mechanisms.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FGF20 antibody (ab198876)
Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue labeling FGF20 with ab198876 at 1/20 dilution.
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Product protocols
- Visit the general protocols
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