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AB74860

Anti-FGF22 antibody

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(2 Publications)

Rabbit Polyclonal FGF22 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human FGF22.

View Alternative Names

UNQ2500/PRO5800, FGF22, Fibroblast growth factor 22, FGF-22

3 Images
Immunocytochemistry/ Immunofluorescence - Anti-FGF22 antibody (AB74860)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-FGF22 antibody (AB74860)

Immunofluorescence analysis of FGF22 in MCF-7 cells using ab74860, at 1/500 dilution, in the presence (right panel) or absence (left panel) of immunising peptide.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FGF22 antibody (AB74860)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FGF22 antibody (AB74860)

Immunohistochemistry analysis of FGF22 in paraffin-embedded human ovary tissue using ab74860, at 1/50 dilution, in the presence (right panel) or absence (left panel) of immunising peptide.

Western blot - Anti-FGF22 antibody (AB74860)
  • WB

Unknown

Western blot - Anti-FGF22 antibody (AB74860)

All lanes:

Western blot - Anti-FGF22 antibody (ab74860) at 1/500 dilution

Lane 1:

Extracts from Jurkat cells at 5 µg

Lane 2:

Extracts from HT-29 cells at 5 µg

Lane 3:

Extracts from Jurkat cells at 5 µg with immunising peptide

Predicted band size: 20 kDa

Observed band size: 21 kDa,55 kDa,85 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, ICC/IF, WB

applications

Immunogen

Synthetic Peptide within Human FGF22. The exact immunogen used to generate this antibody is proprietary information.

Q9HCT0

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Alternative Products

Proteins & Peptides

AB255999

Recombinant Human FGF22 protein

SDS-PAGE - Recombinant Human FGF22 protein (AB255999)

  • 0
  • 0

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/100", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/500 - 1/1000", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

FGF22 also known as Fibroblast Growth Factor 22 is a signaling protein that belongs to the fibroblast growth factor family. It has a molecular mass of approximately 22 kDa. FGF22 is primarily expressed in specific areas of the brain such as the hippocampus and cerebellum as well as in skin tissue. Its mechanism involves binding to FGF receptors which results in the activation of downstream signaling cascades that influence various cellular processes.
Biological function summary

FGF22 plays an important role in nervous system development by promoting the differentiation and maturation of neurons. FGF22 also participates in the formation of synapses contributing to neural connectivity. It does not typically function as part of a complex but acts directly through interactions with its receptor partners. Its expression in peripheral tissues suggests a role in wound healing and skin regeneration.

Pathways

This protein is an integral component of the FGF signaling pathway which is essential for numerous developmental and physiological processes. Through this pathway FGF22 plays a prominent role in synaptic organization and plasticity. It interacts with proteins such as FGFR1 and FGFR2 which are important in mediating its activity in neuronal tissue. The MAPK/ERK pathway is another significant pathway through which FGF22 exerts its effects on cell proliferation and differentiation.

Dysregulation of FGF22 has been linked to neurological conditions such as epilepsy and major depressive disorder. Abnormal FGF22 signaling can alter synaptic functions and impair neuronal communication contributing to these conditions. Additionally FGF22's relationship with other growth factors like NGF (nerve growth factor) enhances its influence on neuronal health and pathology making it a potential target in therapeutic strategies aimed at treating these disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Plays a role in the fasting response, glucose homeostasis, lipolysis and lipogenesis. Can stimulate cell proliferation (in vitro). May be involved in hair development.
See full target information FGF22
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Theriogenology 125:1-5 PubMed30366151

2018

Expression of fibroblast growth factor 22 (FGF22) and its receptor, FGFR1B, during development and regression of bovine corpus luteum.

Applications

Unspecified application

Species

Unspecified reactive species

A C S Castilho,F M Dalanezi,F F Franchi,C A Price,J C P Ferreira,E Trevisol,J Buratini

Reproduction, fertility, and development 29:234-243 PubMed26194863

2015

Evidence that fibroblast growth factor 10 plays a role in follicle selection in cattle.

Applications

Unspecified application

Species

Unspecified reactive species

A C S Castilho,C A Price,F Dalanezi,R L Ereno,M F Machado,C M Barros,B G Gasperin,P B D Gonçalves,J Buratini
View all publications
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Product promise

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For full details, please see our Terms & Conditions

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