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AB106355

Anti-FGF4 antibody

1

(1 Review)

|

(5 Publications)

Rabbit Polyclonal FGF4 antibody. Suitable for WB and reacts with Mouse, Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human FGF4.

View Alternative Names

HST, HSTF1, KS3, FGF4, Fibroblast growth factor 4, FGF-4, Heparin secretory-transforming protein 1, Heparin-binding growth factor 4, Transforming protein KS3, HST-1, HSTF-1, HBGF-4

1 Images
Western blot - Anti-FGF4 antibody (AB106355)
  • WB

Supplier Data

Western blot - Anti-FGF4 antibody (AB106355)

Lane 1:

Western blot - Anti-FGF4 antibody (ab106355) at 0.5 µg/mL

Lane 2:

Western blot - Anti-FGF4 antibody (ab106355) at 1 µg/mL

All lanes:

NIH 3T3 cell lysate at 15 µg

Predicted band size: 22 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human FGF4. The exact immunogen used to generate this antibody is proprietary information.

P08620

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "0.5-1 µg/mL", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-1 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
Up to 12 months
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The FGF4 protein also known as fibroblast growth factor 4 is an important player in cell proliferation differentiation and survival. It is part of the fibroblast growth factor family which consists of over 20 known members. The FGF4 protein has a mass of approximately 22 kDa. Researchers observe its expression in various tissues including the embryo and certain adult tissues where it contributes to developmental processes and tissue repair. FGF4 signalling plays a significant role in embryogenesis.
Biological function summary

FGF4 protein regulates pathways involved in cell development and morphogenesis. It particularly influences the formation of limbs and the development of the nervous system. FGF4 usually functions as a part of signaling complexes interacting with its specific receptors on the cell surface. These interactions will lead to a cascade of downstream signaling events that modulate gene expression and cellular behavior.

Pathways

FGF4 engages with multiple signaling pathways notably the MAPK/ERK pathway and the PI3K/AKT pathway. Through these pathways FGF4 protein orchestrates cellular responses important for proper tissue organization and differentiation. It often functions alongside other proteins like FGF2 and FGF8 which share overlapping roles in similar developmental and cellular processes. These interactions underline the complexity and redundancy within the fibroblast growth factor family in ensuring robust biological outcomes.

Dysregulation of FGF4 protein associates with conditions like cancer and developmental defects. Overactive FGF4 signaling has been linked to tumor growth and progression as it can drive unchecked cellular proliferation and survival. Furthermore altered FGF4 expression may relate to syndromes affecting limb development. In the context of these diseases FGF4 can interact with proteins such as FGFR1 leading to aberrant signaling pathways contributing to pathogenesis.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis. May play a role in embryonic molar tooth bud development via inducing the expression of MSX1, MSX2 and MSX1-mediated expression of SDC1 in dental mesenchyme cells (By similarity).
See full target information FGF4
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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Cell division 20:22 PubMed41039618

2025

FGF4 drives tumor progression in triple-negative breast cancer via IL6/STAT3-mediated macrophage M2 polarization and immune suppression.

Applications

Unspecified application

Species

Unspecified reactive species

Xuanhe Zhang,Shushan Zhang,Yuanyuan Han

Stem cell research & therapy 13:336 PubMed35870977

2022

Exosomes from mmu_circ_0001052-modified adipose-derived stem cells promote angiogenesis of DFU via miR-106a-5p and FGF4/p38MAPK pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Zun-Hong Liang,Nan-Fang Pan,Shi-Shuai Lin,Zhi-Yang Qiu,Ping Liang,Jun Wang,Zhi Zhang,Yun-Chuan Pan

Frontiers in pharmacology 13:827617 PubMed35317005

2022

FGF4, A New Potential Regulator in Gestational Diabetes Mellitus.

Applications

Unspecified application

Species

Unspecified reactive species

Miaojuan Fan,Tongtong Pan,Wei Jin,Jian Sun,Shujun Zhang,Yali Du,Xinwei Chen,Qiong Chen,Wenxin Xu,Siew Woh Choo,Guanghui Zhu,Yongping Chen,Jie Zhou

American journal of translational research 12:8147-8161 PubMed33437388

2020

Methyl-CpG-binding domain 3 (Mbd3) is an important regulator for apoptosis in mouse embryonic stem cells.

Applications

Unspecified application

Species

Unspecified reactive species

Yujian Dai,Jinshan Li,Mingyang Li,Zhihui Liu,Jiao Liu,Liyou An,Fuliang Du

Oncogene 36:5874-5884 PubMed28628113

2017

MicroRNA-20a-mediated loss of autophagy contributes to breast tumorigenesis by promoting genomic damage and instability.

Applications

Unspecified application

Species

Unspecified reactive species

L Liu,J He,X Wei,G Wan,Y Lao,W Xu,Z Li,H Hu,Z Hu,X Luo,J Wu,W Xie,Y Zhang,N Xu
View all publications
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Product promise

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