Rabbit Polyclonal FGFBP1 antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human FGFBP1.
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Publications
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- Medical oncology (Northwood, London, England) 41:172023KLF5 promotes esophageal squamous cell cancer through the transcriptional activation of FGFBP1.Applications:Unspecified applicationReactive species:Unspecified reactive speciesFengyun Wang,Ming Luo,Yufeng ChengPubMed 38087142
- FEBS open bio :2021BAP1 promotes viability and migration of ECA109 cells through KLF5/CyclinD1/FGF-BP1.Applications:Unspecified applicationReactive species:Unspecified reactive speciesFengyun Wang et. al.PubMed 33529461
- Oncology letters 16:809-8142018FGFRL1 deficiency reduces motility and tumorigenic potential of cells derived from oesophageal squamous cell carcinomas.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYoshinori Takei et. al.PubMed 29963148
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.05% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human FGFBP1. The exact immunogen used to generate this antibody is proprietary information. Database link Q14512
Reactivity data
Select an application| WB | |
|---|---|
| Human | Tested |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/350.00000 - 1/2000.00000 | Notes - |
Associated Products
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2 products for Alternative Product
Target data
Function
Acts as a carrier protein that release fibroblast-binding factors (FGFs) from the extracellular matrix (EM) storage and thus enhance the mitogenic activity of FGFs. Enhances FGF2 signaling during tissue repair, angiogenesis and in tumor growth.
Alternative names
FGFBP, HBP17, FGFBP1, Fibroblast growth factor-binding protein 1, FGF-BP, FGF-BP1, FGF-binding protein 1, FGFBP-1, 17 kDa heparin-binding growth factor-binding protein, 17 kDa HBGF-binding protein, HBp17
Recommended products
Rabbit Polyclonal FGFBP1 antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human FGFBP1.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.05% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human FGFBP1. The exact immunogen used to generate this antibody is proprietary information. Database link Q14512
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
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Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
FGFBP1 also known as fibroblast growth factor binding protein 1 is an extracellular regulatory protein that mechanically binds fibroblast growth factors (FGFs). This protein has a molecular mass of approximately 30 kilodaltons. FGFBP1 is expressed in various tissues including the skin liver and kidney. It acts as a carrier enhancing the bioavailability of FGFs by releasing them from the extracellular matrix or cell surfaces facilitating their interaction with FGF receptors.
- Biological function summary
FGFBP1 plays a significant role in modulating FGF signaling influencing processes such as angiogenesis wound healing and tissue repair. It acts in conjunction with other FGFs to form a complex that is essential for efficient signal transduction across cellular membranes. By interacting with FGFs FGFBP1 impacts cell proliferation and differentiation particularly in epithelial and endothelial cells.
- Pathways
FGFBP1 is a critical component of the FGF signaling pathway and has a role in pathways related to cell growth and tissue development. It works alongside other proteins such as FGF1 and FGF2 to regulate developmental processes. The interaction of FGFBP1 in the signaling pathway ensures the proper function and maintenance of cellular activities aligning with processes like angiogenesis and morphogenesis.
- Associated diseases and disorders
FGFBP1 has connections to cancer and chronic inflammatory diseases such as psoriasis. In cancer FGFBP1's role in promoting FGF-mediated angiogenesis supports tumor growth and metastasis especially in collaboration with other FGFs like FGF2. In chronic inflammatory disorders dysregulation of FGFBP1 can lead to aberrant FGF signaling contributing to excessive tissue inflammation and impaired healing. This highlights its potential as a target for therapeutic intervention in these conditions.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Western blot - Anti-FGFBP1 antibody (ab215353)
Gel: 12%SDS-PAGE
All lanes: Western blot - Anti-FGFBP1 antibody (ab215353) at 1/350 dilution
All lanes: A549 cell lysate at 40 µg
SecondaryAll lanes: Goat anti rabbit IgG at 1/8000 dilution
Developed using the ECL technique.
Predicted band size: 26 kDa
Exposure time: 1min
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