JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB238155

Anti-FGFBP1 antibody

Be the first to review this product! Submit a review

|

(1 Publication)

Rabbit Polyclonal FGFBP1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human FGFBP1.

View Alternative Names

FGFBP, HBP17, FGFBP1, Fibroblast growth factor-binding protein 1, FGF-BP, FGF-BP1, FGF-binding protein 1, FGFBP-1, 17 kDa heparin-binding growth factor-binding protein, 17 kDa HBGF-binding protein, HBp17

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FGFBP1 antibody (AB238155)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FGFBP1 antibody (AB238155)

Paraffin-embedded human tonsil tissue stained for FGFBP1 with ab238155 at a 1/100 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FGFBP1 antibody (AB238155)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FGFBP1 antibody (AB238155)

Paraffin-embedded human breast cancer tissue stained for FGFBP1 with ab238155 at a 1/100 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Full Length Protein corresponding to Human FGFBP1.

Q14512

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

FGFBP1 also known as fibroblast growth factor binding protein 1 is an extracellular regulatory protein that mechanically binds fibroblast growth factors (FGFs). This protein has a molecular mass of approximately 30 kilodaltons. FGFBP1 is expressed in various tissues including the skin liver and kidney. It acts as a carrier enhancing the bioavailability of FGFs by releasing them from the extracellular matrix or cell surfaces facilitating their interaction with FGF receptors.
Biological function summary

FGFBP1 plays a significant role in modulating FGF signaling influencing processes such as angiogenesis wound healing and tissue repair. It acts in conjunction with other FGFs to form a complex that is essential for efficient signal transduction across cellular membranes. By interacting with FGFs FGFBP1 impacts cell proliferation and differentiation particularly in epithelial and endothelial cells.

Pathways

FGFBP1 is a critical component of the FGF signaling pathway and has a role in pathways related to cell growth and tissue development. It works alongside other proteins such as FGF1 and FGF2 to regulate developmental processes. The interaction of FGFBP1 in the signaling pathway ensures the proper function and maintenance of cellular activities aligning with processes like angiogenesis and morphogenesis.

FGFBP1 has connections to cancer and chronic inflammatory diseases such as psoriasis. In cancer FGFBP1's role in promoting FGF-mediated angiogenesis supports tumor growth and metastasis especially in collaboration with other FGFs like FGF2. In chronic inflammatory disorders dysregulation of FGFBP1 can lead to aberrant FGF signaling contributing to excessive tissue inflammation and impaired healing. This highlights its potential as a target for therapeutic intervention in these conditions.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Acts as a carrier protein that release fibroblast-binding factors (FGFs) from the extracellular matrix (EM) storage and thus enhance the mitogenic activity of FGFs. Enhances FGF2 signaling during tissue repair, angiogenesis and in tumor growth.
See full target information FGFBP1
style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cancer medicine 13:e7021 PubMed38562019

2024

Metformin suppresses NFE2L1 pathway activation to inhibit gap junction beta protein expression in NSCLC.

Applications

Unspecified application

Species

Unspecified reactive species

Shuo Yu,Hui Ren,Tingting Liu,Xiaoyan Han,Hui Guo,Qian Ning,Yang Li,Hong Zhou,Mingwei Chen,Tinghua Hu
View all publications
style
left-column
style
left-column
style
right-column

Alternative Products

Primary Antibodies

AB215353

Anti-FGFBP1 antibody

Western blot - Anti-FGFBP1 antibody (AB215353)

  • 0
  • 0

Complementary Products

Primary Antibodies

AB16502

Anti-NF-kB p65 antibody

BOND RX™ Validated|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NF-kB p65 antibody (AB16502)

  • 4
  • 40
Sample Prep & Detection Kits

AB500

ChIP Kit

ChIP - ChIP Kit (AB500)

  • 4
  • 4
Primary Antibodies

AB67785

Anti-TRIM31 antibody

Western blot - Anti-TRIM31 antibody (AB67785)

  • 0
  • 0
Primary Antibodies

AB42355

Anti-HIV1 Nef antibody [3D12]

Western blot - Anti-HIV1 Nef antibody [3D12] (AB42355)

  • 4
  • 1

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com