Rabbit Polyclonal FGFR1 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 8 publications. Immunogen corresponding to Synthetic Peptide within Human FGFR1_HUMAN.
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Publications
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- Frontiers in cardiovascular medicine 9:10111672022Fibroblast growth factor receptor signaling in cardiomyocytes is protective in the acute phase following ischemia-reperfusion injury.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDzmitry Matsiukevich,Stacey L House,Carla Weinheimer,Attila Kovacs,David M OrnitzPubMed 36211556
- Oncology letters 17:2303-23072019A potential novel therapy for FGFR1-amplified pancreatic cancer with bone metastasis, screened by next-generation sequencing and a patient-derived xenograft model.Applications:Unspecified applicationReactive species:Unspecified reactive speciesZhonghai Guan,Huanrong Lan,Dan Sun,Xuanwei Wang,Ketao JinPubMed 30719110
- American journal of physiology. Lung cellular and molecular physiology 316:L229-L2442018Consequences of early postnatal lipopolysaccharide exposure on developing lungs in mice.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAmrit Kumar Shrestha,Matthew L Bettini,Renuka T Menon,Vashisht Y N Gopal,Shixia Huang,Dean P Edwards,Mohan Pammi,Roberto Barrios,Binoy ShivannaPubMed 30307313
- Cellular physiology and biochemistry : internation 42:1623-16342017Thermal Preconditioning May Prevent Tendon Adhesion by Up-Regulating HSP72 in Rats.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYang Tan et. al.PubMed 28738356
- The Journal of clinical investigation 126:1871-842016Tyrosine kinase inhibitor NVP-BGJ398 functionally improves FGFR3-related dwarfism in mouse model.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDavide Komla-Ebri et. al.PubMed 27064282
- American journal of physiology. Gastrointestinal a 308:G678-902015Fibroblast growth factor 10 alters the balance between goblet and Paneth cells in the adult mouse small intestine.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDenise Al Alam et. al.PubMed 25721301
- PLoS biology 7:e10001722009Persistent cAMP-signals triggered by internalized G-protein-coupled receptors.
- Calcified tissue international 85:235-462009Survey of the enthesopathy of X-linked hypophosphatemia and its characterization in Hyp mice.Applications:IHC-PReactive species:MouseGuoying Liang,Lee D Katz,Karl L Insogna,Thomas O Carpenter,Carolyn M MacicaPubMed 19609735
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride- Form
Liquid
- Clonality
Polyclonal
Immunogen
- Synthetic Peptide within Human FGFR1_HUMAN. The exact immunogen used to generate this antibody is proprietary information. Database link P11362
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Reactivity data
Select an application| WB | IHC-P | |
|---|---|---|
| Human | Tested | Tested |
| Mouse | Predicted | Predicted |
| Rat | Predicted | Predicted |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/500 - 1/1000 | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat | Dilution info - | Notes - |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/50 - 1/100 | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat | Dilution info - | Notes - |
Associated Products
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6 products for Alternative Product
Target data
Function
Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation.
Alternative names
BFGFR, CEK, FGFBR, FLG, FLT2, HBGFR, FGFR1, BFGFR, CEK, FGFBR, FLG, FLT2, HBGFR, Fibroblast growth factor receptor 1, FGFR-1, Basic fibroblast growth factor receptor 1, Fms-like tyrosine kinase 2, N-sam, Proto-oncogene c-Fgr, BFGFR, bFGF-R-1, FLT-2
Recommended products
Rabbit Polyclonal FGFR1 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 8 publications. Immunogen corresponding to Synthetic Peptide within Human FGFR1_HUMAN.
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride- Form
Liquid
- Clonality
Polyclonal
- Immunogen
- Synthetic Peptide within Human FGFR1_HUMAN. The exact immunogen used to generate this antibody is proprietary information. Database link P11362
- Purification technique
Affinity purification Immunogen
- Concentration
- Purification notes
ab63601 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
- Shipped at conditions
Blue Ice
- Appropriate short-term storage conditions
+4°C
- Appropriate long-term storage conditions
-20°C
- Storage information
Stable for 12 months at -20°C
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
FGFR1 also known as fibroblast growth factor receptor 1 is a protein with a molecular weight of approximately 92 kDa. It is a receptor tyrosine kinase that binds to fibroblast growth factors (FGFs) triggering a cascade of downstream signaling pathways. FGFR1 is widely expressed in various tissues including the brain skeletal muscle and the cardiovascular system. The FGFR1 protein plays an essential role in cellular processes such as proliferation differentiation and survival.
- Biological function summary
FGFR1 is significant in embryonic development and tissue repair. It does not function alone; rather it forms a complex with fibroblast growth factors and heparan sulfate proteoglycans facilitating receptor dimerization and autophosphorylation. FGFR1 is involved in bone growth angiogenesis and wound healing processes. The interaction of FGFR1 with these complex factors ensures the precise regulation of these critical physiological events in the body.
- Pathways
FGFR1 participates actively in the MAPK/ERK and PI3K/AKT signaling pathways. These pathways are vital for transmitting signals from the cell surface to the DNA in the cell nucleus regulating gene expression and affecting cell cycle progression. FGFR1 works alongside similar proteins like FGFR2 influencing cell fate decisions. By modulating these pathways FGFR1 ensures a proper response to environmental signals which maintains homeostasis and adapts to physiological needs.
- Associated diseases and disorders
FGFR1 is implicated in conditions such as cancer and skeletal dysplasias. Abnormal FGFR1 signaling due to mutations or overexpression can lead to tumorigenesis contributing to the development of cancers like breast and lung cancer. The protein FGFR2 is often evaluated in parallel for similar oncogenic activities. Moreover FGFR1-related dysregulation in bone development can result in skeletal disorders highlighting its importance in both normal physiology and pathological conditions. Anti-FGFR therapies and FGFR1 ELISA tools are being explored to better understand and tackle these diseases.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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3 product images
Western blot - Anti-FGFR1 antibody (ab63601)
All lanes: Western blot - Anti-FGFR1 antibody (ab63601)
All lanes: HepG2 cell lysate
Predicted band size: 92 kDa
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FGFR1 antibody (ab63601)
ab63601, at 1/50 dilution, staining FGFR1 in human breast carcinoma by Immunohistochemistry on paraffin-embedded tissue, in the absence (left image) or presence (right image) of immunising peptide.
Western blot - Anti-FGFR1 antibody (ab63601)
All lanes: Western blot - Anti-FGFR1 antibody (ab63601)
All lanes: HepG2 cell lysate
Predicted band size: 92 kDa
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