AB156013

Anti-FGFR1 Oncogene Partner antibody [EPR9929]

RabMAb
Recombinant
What is this?

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(2 Publications)

Rabbit Recombinant Monoclonal FGFR1 Oncogene Partner antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 2 publications.

View Alternative Names

FGFR1OP, FOP, CEP43, Centrosomal protein 43, FGFR1 oncogene partner

2 Images

Immunocytochemistry/ Immunofluorescence - Anti-FGFR1 Oncogene Partner antibody [EPR9929] (AB156013)

ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-FGFR1 Oncogene Partner antibody [EPR9929] (AB156013)

Immunofluorescent analysis of HeLa cells labeling FGFR1 Oncogene Partner with ab156013 at 1/100 dilution.

Lab

Western blot - Anti-FGFR1 Oncogene Partner antibody [EPR9929] (AB156013)

All lanes:

Western blot - Anti-FGFR1 Oncogene Partner antibody [EPR9929] (ab156013) at 1/1000 dilution

Lane 1:

HeLa cell lysate at 10 µg

Lane 2:

293T cell lysate at 10 µg

Lane 3:

Saos-2 cell lysate at 10 µg

Secondary

All lanes:

HRP labelled goat anti-rabbit at 1/2000 dilution

Predicted band size: 43 kDa

false

Carrier free

Anti-FGFR1 Oncogene Partner antibody [EPR9929] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR9929

Isotype

IgG

Carrier free

Reacts with

Human

Applications

WB, ICC/IF

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/250", "ICCIF-species-notes": "" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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Product details

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA

Shipped at conditions

Conditional Ambient

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The FGFR1 Oncogene Partner also known as FOP is a protein predominantly involved in cellular processes related to the fibroblast growth factor receptor 1 (FGFR1). It exhibits a molecular weight of approximately 60 kDa. FGFR1 Oncogene Partner is expressed in various tissues including bone marrow and other hematopoietic tissues. It contains conserved regions essential for its function as a molecular adaptor or scaffold playing a significant role in protein-protein interactions.

Biological function summary

FOP functions as an adaptor protein facilitating the assembly and organization of the centrosome a critical cellular structure required for proper cell division. FOP plays a role in the formation of a multi-protein complex comprising FGFR1 contributing to cellular signaling regulation. This complex assists in ensuring appropriate cellular responses to growth factor stimuli. FOP displays interactions with other cytoskeletal and signaling proteins highlighting its importance in modulating cellular architecture and division.

Pathways

Various proteins interact with FGFR1 Oncogene Partner as part of the FGFR signaling and centrosome architecture processes. The primary pathway involving FOP is the FGFR signaling pathway where it facilitates the FGFR1's recruitment to the centrosome. This interaction allows for efficient signal transduction necessary for cell proliferation and differentiation. FOP also associates with proteins like ALMS1 affecting cellular organization and stability highlighting its participation in centrosome-related signaling cascades.

Alterations in FOP expression or function have links to various conditions notably cancer and craniosynostosis. In certain cancers FOP involvement with FGFR1 leads to oncogenic fusion proteins enhancing aberrant signaling and contributing to tumor growth and progression. Furthermore craniosynostosis links to disruptions in centrosome functionality where mutated FOP can affect skeletal development. The protein's interactions with FGFR1 and other centrosomal partners position it significantly in the etiology of these diseases.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Required for anchoring microtubules to the centrosomes (PubMed : 16314388, PubMed : 28659385). Required for ciliation (PubMed : 28625565, PubMed : 28659385).

See full target information CEP43

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in cell and developmental biology 8:590449 PubMed33304902

2020

FOP Negatively Regulates Ciliogenesis and Promotes Cell Cycle Re-entry by Facilitating Primary Cilia Disassembly.

Applications

Unspecified application

Species

Unspecified reactive species

Huadong Jiang,Shanshan Liu,Man-Hei Cheung,Aftab Amin,Chun Liang

Proceedings of the National Academy of Sciences of 111:13960-5 PubMed25201987

2014

Neuronal necrosis is regulated by a conserved chromatin-modifying cascade.

Applications

Unspecified application

Species

Unspecified reactive species

Kai Liu,Lianggong Ding,Yuhong Li,Hui Yang,Chunyue Zhao,Ye Lei,Shuting Han,Wei Tao,Dengshun Miao,Hermann Steller,Michael J Welsh,Lei Liu

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-FGFR1 Oncogene Partner antibody [EPR9929]

Immunocytochemistry/ Immunofluorescence - Anti-FGFR1 Oncogene Partner antibody [EPR9929] (AB156013)

Western blot - Anti-FGFR1 Oncogene Partner antibody [EPR9929] (AB156013)

Related conjugates and formulations (1)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

Complementary Products

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Product details

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (2)

Product promise