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AB229119

Anti-FGFR1OP2 antibody

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(1 Publication)

Rabbit Polyclonal FGFR1OP2 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human FGFR1OP2.

View Alternative Names

HSPC123, FGFR1OP2, FGFR1 oncogene partner 2

4 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FGFR1OP2 antibody (AB229119)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FGFR1OP2 antibody (AB229119)

Paraffin-embedded H441 xenograft tissue stained for FGFR1OP2 with ab229119 at 1/500 dilution in immunohistochemical analysis.

Immunocytochemistry/ Immunofluorescence - Anti-FGFR1OP2 antibody (AB229119)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-FGFR1OP2 antibody (AB229119)

Methanol-fixed MCF7 (human breast adenocarcinoma cell line) cells stained for FGFR1OP2 (green) using ab229119 at 1/500 dilution in ICC/IF.

Nuclear counterstain : Hoechst 33342 (blue).

Western blot - Anti-FGFR1OP2 antibody (AB229119)
  • WB

Supplier Data

Western blot - Anti-FGFR1OP2 antibody (AB229119)

12% SDS-PAGE

All lanes:

Western blot - Anti-FGFR1OP2 antibody (ab229119) at 1/2000 dilution

All lanes:

MCF7 (human breast adenocarcinoma cell line) whole cell lysate at 30 µg

Predicted band size: 29 kDa

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Western blot - Anti-FGFR1OP2 antibody (AB229119)
  • WB

Unknown

Western blot - Anti-FGFR1OP2 antibody (AB229119)

12% SDS-PAGE

All lanes:

Western blot - Anti-FGFR1OP2 antibody (ab229119) at 1/1000 dilution

All lanes:

Mouse stomach tissue lysate at 50 µg

Predicted band size: 29 kDa

true

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB, ICC/IF, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human FGFR1OP2. The exact immunogen used to generate this antibody is proprietary information.

Q9NVK5

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/1000", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The FGFR1OP2 protein also known as Fgfr1 Oncogene Partner 2 is a critical component in cellular structural dynamics. It has a molecular mass of approximately 50 kDa. Researchers have identified FGFR1OP2 in different cellular environments including osteoblasts and hematopoietic cells. This presence in diverse tissues suggests a versatile role in cellular processes. The protein participates actively in regulating cytoskeletal integrity and cellular shape reflective of its structural significance.
Biological function summary

FGFR1OP2 interacts with cellular structures and complexes that modulate cytoskeletal components. It helps maintain cellular integrity and facilitate signal transduction processes. FGFR1OP2 can play a part in the centrosome where it aids in maintaining organization and stabilization of microtubules. This role feeds into broader cellular functions like cell division and migration which rely heavily on cytoskeletal adjustments.

Pathways

FGFR1OP2 takes part in cellular processes that involve cytoskeleton-related signaling and reorganization. The protein associates closely with the Ran GTPase pathway which impacts nuclear transport and microtubule organization. FGFR1OP2 also connects with the growth factor receptor (notably FGFR1) signaling pathways. These interactions help manage proliferation signals and cellular structure modifications which are essential during cell cycle events.

FGFR1OP2 shows a relationship with certain types of cancer particularly acute myeloid leukemia (AML) where chromosomal translocations involving FGFR1 can occur. Researchers found that FGFR1OP2 forms fusion proteins which drive aberrant signaling pathways linked to oncogenesis. Another connection between FGFR1OP2 exists in the context of skeletal disorders as its role in osteoblast function may impact bone density and structural anomalies when dysregulated. Through these diseases FGFR1OP2 interacts with proteins like FGFR1 and others involved in cellular growth controls.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May be involved in wound healing pathway.
See full target information FGFR1OP2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular sciences 24: PubMed37298552

2023

Endogenous TOM20 Proximity Labeling: A Swiss-Knife for the Study of Mitochondrial Proteins in Human Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Sébastien Meurant,Lorris Mauclet,Marc Dieu,Thierry Arnould,Sven Eyckerman,Patricia Renard
View all publications
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Product promise

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