Rabbit Polyclonal FGFR4 antibody. Suitable for WB and reacts with Rat samples. Cited in 7 publications. Immunogen corresponding to Synthetic Peptide within Human FGFR4 conjugated to Keyhole Limpet Haemocyanin.
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- Frontiers in pharmacology 14:11487372023Geniposide plus chlorogenic acid reverses non-alcoholic steatohepatitis regulation of gut microbiota and bile acid signaling in a mouse model .Applications:Unspecified applicationReactive species:Unspecified reactive speciesHongshan Li,Yingfei Xi,Xin Xin,Qin Feng,Yiyang HuPubMed 37077819
- Frontiers in cardiovascular medicine 10:9904222023Indoxyl sulfate induces left ventricular hypertrophy the AhR-FGF23-FGFR4 signaling pathway.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHiroshi Kishimoto,Toshiaki Nakano,Kumiko Torisu,Masanori Tokumoto,Yushi Uchida,Shunsuke Yamada,Masatomo Taniguchi,Takanari KitazonoPubMed 36895836
- mSystems 7:e00172222022Dietary Exposure to Antibiotic Residues Facilitates Metabolic Disorder by Altering the Gut Microbiota and Bile Acid Composition.Applications:Unspecified applicationReactive species:Unspecified reactive speciesRou-An Chen,Wei-Kai Wu,Suraphan Panyod,Po-Yu Liu,Hsiao-Li Chuang,Yi-Hsun Chen,Qiang Lyu,Hsiu-Ching Hsu,Tzu-Lung Lin,Ting-Chin David Shen,Yu-Tang Yang,Hsin-Bai Zou,Huai-Syuan Huang,Yu-En Lin,Chieh-Chang Chen,Chi-Tang Ho,Hsin-Chih Lai,Ming-Shiang Wu,Cheng-Chih Hsu,Lee-Yan SheenPubMed 35670534
- Nutrition & metabolism 17:342020Gypenosides regulate farnesoid X receptor-mediated bile acid and lipid metabolism in a mouse model of non-alcoholic steatohepatitis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHongshan Li et. al.PubMed 32377219
- FEBS open bio 9:769-7802019FGF11 influences 3T3-L1 preadipocyte differentiation by modulating the expression of PPARγ regulators.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKyeong Won Lee et. al.PubMed 30984550
- Hepatology communications 2:821-8352018Molecular magnetic resonance imaging accurately measures the antifibrotic effect of EDP-305, a novel farnesoid X receptor agonist.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDerek J Erstad,Christian T Farrar,Sarani Ghoshal,Ricard Masia,Diego S Ferreira,Yin-Ching Iris Chen,Ji-Kyung Choi,Lan Wei,Phillip A Waghorn,Nicholas J Rotile,Chuantao Tu,Katherine A Graham-O'Regan,Mozhdeh Sojoodi,Shen Li,Yang Li,Guogiang Wang,Kathleen E Corey,Yat Sun Or,Lijuan Jiang,Kenneth K Tanabe,Peter Caravan,Bryan C FuchsPubMed 30027140
- BMC microbiology 13:2382013Enterohepatic bacterial infections dysregulate the FGF15-FGFR4 endocrine axis.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 48% PBS, 0.88% Sodium chloride- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human FGFR4 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information. Database link P22455
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Reactivity data
Select an application| WB | |
|---|---|
| Rat | Tested |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Rat | Dilution info 1/500 - 1/1000 | Notes - |
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4 products for Alternative Product
Target data
Function
Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4. Mutations that lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling.
Alternative names
CD334, JTK2, TKF, FGFR4, Fibroblast growth factor receptor 4, FGFR-4
Recommended products
Rabbit Polyclonal FGFR4 antibody. Suitable for WB and reacts with Rat samples. Cited in 7 publications. Immunogen corresponding to Synthetic Peptide within Human FGFR4 conjugated to Keyhole Limpet Haemocyanin.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 48% PBS, 0.88% Sodium chloride- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human FGFR4 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information. Database link P22455
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Stable for 12 months at -20°C
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
FGFR4 or fibroblast growth factor receptor 4 is a receptor tyrosine kinase weighing approximately 110 kDa. This protein plays a role in cellular processes by binding to fibroblast growth factors. FGFR4 is expressed in many tissues including muscle liver and the developing epidermis. It is known by alternate names like CD334 or FRFR4. This receptor's activation leads to receptor dimerization and autophosphorylation triggering downstream signaling pathways that affect cell proliferation differentiation and migration.
- Biological function summary
FGFR4 influences various developmental and metabolic processes. It is important in limb and skeletal development epithelial cell morphogenesis and muscle fiber regeneration. FGFR4 often partners with heparan sulfate proteoglycans to form a signaling complex which defines the specificity and regulation of fibroblast growth factor signaling. The receptor's interaction with other proteins like FRFR4 and 5b5 further modulates its biological activity.
- Pathways
FGFR4 participates in the MAPK and PI3K-Akt signaling pathways both important for regulating cell survival and growth. These pathways allow FGFR4 to connect with several other proteins such as FGFR1 and BLU-554. FGFR4's activation within these pathways helps determine cellular responses to hormonal and mitogenic signals further influencing tissue homeostasis and repair mechanisms.
- Associated diseases and disorders
FGFR4 is linked to certain cancers including hepatocellular carcinoma and colorectal cancer notable in cell lines like HCT116 and others. Overexpression or mutations in FGFR4 can drive tumor progression promoting uncontrolled growth and metastasis. FGFR4's relation to other key proteins such as FRAF and 19h3 highlights its role in pathogenesis making it a potential target for therapeutic interventions. Studies involving FGFR4 ELISA kits enhance understanding of its role in disease development and progression.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Western blot - Anti-FGFR4 antibody (ab119378)
All lanes: Western blot - Anti-FGFR4 antibody (ab119378) at 1/500 dilution
Lane 1: Rat liver lysate
Lane 2: Rat brain lysate
Predicted band size: 57 kDa, 88 kDa
Observed band size: 110 kDa
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