Rabbit Polyclonal FGL2/Prothrombinase antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human FGL2.
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- Frontiers in medicine 9:8276952022Identification and Validation of Immune Molecular Subtypes and Immune Landscape Based on Colon Cancer Cohort.Applications:Unspecified applicationReactive species:Unspecified reactive speciesWenqian Qi,Qian ZhangPubMed 35602471
- Cell death & disease 13:1302022Stat4 rs7574865 polymorphism promotes the occurrence and progression of hepatocellular carcinoma via the Stat4/CYP2E1/FGL2 pathway.Applications:Unspecified applicationReactive species:Unspecified reactive speciesCaie Wang,Na Gao,Lukui Yang,Yuanyuan Guo,Yan Fang,Tong Wang,Chen Xu,Gui Fang Li,Jun Zhou,Yunfei Zhang,Qiang Wen,Hailing QiaoPubMed 35136014
- The journal of gene medicine 20:e30232018Soluble Fgl2 restricts autoimmune hepatitis progression via suppressing Tc17 and conventional CD8+ T cell function.Applications:Unspecified applicationReactive species:Unspecified reactive speciesGuo Ai,Weiming Yan,Haijing Yu,Fang Xiao,Dong Xi,Ke Ma,Jiaquan Huang,Xiaoping Luo,Xiaoyang Wan,Qin NingPubMed 29756667
- Molecular medicine reports 16:3445-34542017Elevated fibrinogen‑like protein 2 in TNBS‑induced colitis mice: Association with Th17 and regulatory T cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHaihua Lin et. al.PubMed 28713999
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.05% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human FGL2. The exact immunogen used to generate this antibody is proprietary information. Database link Q14314
Reactivity data
Select an application| WB | IHC-P | |
|---|---|---|
| Human | Expected | Tested |
| Mouse | Tested | Expected |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info 1/450.00000 - 1/2000.00000 | Notes - |
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info Use at an assay dependent concentration. | Notes - |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/20.00000 - 1/100.00000 | Notes - |
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info Use at an assay dependent concentration. | Notes - |
Target data
Function
May play a role in physiologic lymphocyte functions at mucosal sites.
Alternative names
Fibroleukin, Fibrinogen-like protein 2, pT49, FGL2
Recommended products
Rabbit Polyclonal FGL2/Prothrombinase antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human FGL2.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.05% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human FGL2. The exact immunogen used to generate this antibody is proprietary information. Database link Q14314
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
FGL2 also known as Fibroleukin or Prothrombinase is a protein involved in various physiological and pathological processes. Its molecular mass is approximately 70 kDa. This protein is widely expressed in different tissues including the liver and the spleen as well as in immune cells such as T cells and macrophages. It serves as an important signaling molecule and mediator in various biological pathways due to its capacity to interact with other proteins and molecular complexes.
- Biological function summary
FGL2 acts in immune response modulation and blood coagulation. It can exist as a homodimer or form part of a larger protein complex. One of its roles involves cleaving prothrombin to generate thrombin contributing to the coagulation cascade. Moreover FGL2 has immunosuppressive properties affecting T cell proliferation and cytokine release. Its dual function in coagulation and immune regulation points to its importance in maintaining homeostasis and orchestrating immune responses.
- Pathways
FGL2 serves key roles in both the coagulation and immune pathways. In the coagulation pathway FGL2 aids in the conversion of prothrombin to thrombin bridging innate immunity with coagulation processes. This action places it in close functional relationship with proteins in the coagulation pathway such as thrombin and fibrin. Moreover its involvement in immune pathways aligns it with cytokines and interferons modulating the immune response and maintaining immune system balance.
- Associated diseases and disorders
FGL2 plays significant roles in conditions such as viral hepatitis and certain autoimmune disorders. In viral hepatitis FGL2's upregulation contributes to liver fibrosis and inflammation often in conjunction with another protein CD147. In autoimmune disorders the dysregulation of FGL2 can lead to excessive inflammatory responses impacting proteins like the interferon-gamma. Understanding FGL2's involvement in these diseases can inform therapeutic strategies targeting both coagulation and immune dysregulation.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Western blot - Anti-FGL2/Prothrombinase antibody (ab198029)
8% SDS-PAGE
All lanes: Western blot - Anti-FGL2/Prothrombinase antibody (ab198029) at 1/450 dilution
All lanes: Mouse thymus tissue lysate at 40 µg
Predicted band size: 23 kDa, 50 kDa, 65 kDa
Exposure time: 40s
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FGL2/Prothrombinase antibody (ab198029)
Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue labeling FGL2/Prothrombinase with ab198029 at 1/20 dilution.
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