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AB198029

Anti-FGL2/Prothrombinase antibody

1

(1 Review)

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(6 Publications)

Rabbit Polyclonal FGL2/Prothrombinase antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 6 publications. Immunogen corresponding to Recombinant Fragment Protein within Human FGL2.

View Alternative Names

Fibroleukin, Fibrinogen-like protein 2, pT49, FGL2

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FGL2/Prothrombinase antibody (AB198029)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FGL2/Prothrombinase antibody (AB198029)

Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue labeling FGL2/Prothrombinase with ab198029 at 1/20 dilution.

Western blot - Anti-FGL2/Prothrombinase antibody (AB198029)
  • WB

Supplier Data

Western blot - Anti-FGL2/Prothrombinase antibody (AB198029)

8% SDS-PAGE

All lanes:

Western blot - Anti-FGL2/Prothrombinase antibody (ab198029) at 1/450 dilution

All lanes:

Mouse thymus tissue lysate at 40 µg

Predicted band size: 23 kDa,50 kDa,65 kDa

false

Exposure time: 40s

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human FGL2. The exact immunogen used to generate this antibody is proprietary information.

Q14314

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/100", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/450 - 1/2000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

FGL2 also known as Fibroleukin or Prothrombinase is a protein involved in various physiological and pathological processes. Its molecular mass is approximately 70 kDa. This protein is widely expressed in different tissues including the liver and the spleen as well as in immune cells such as T cells and macrophages. It serves as an important signaling molecule and mediator in various biological pathways due to its capacity to interact with other proteins and molecular complexes.
Biological function summary

FGL2 acts in immune response modulation and blood coagulation. It can exist as a homodimer or form part of a larger protein complex. One of its roles involves cleaving prothrombin to generate thrombin contributing to the coagulation cascade. Moreover FGL2 has immunosuppressive properties affecting T cell proliferation and cytokine release. Its dual function in coagulation and immune regulation points to its importance in maintaining homeostasis and orchestrating immune responses.

Pathways

FGL2 serves key roles in both the coagulation and immune pathways. In the coagulation pathway FGL2 aids in the conversion of prothrombin to thrombin bridging innate immunity with coagulation processes. This action places it in close functional relationship with proteins in the coagulation pathway such as thrombin and fibrin. Moreover its involvement in immune pathways aligns it with cytokines and interferons modulating the immune response and maintaining immune system balance.

FGL2 plays significant roles in conditions such as viral hepatitis and certain autoimmune disorders. In viral hepatitis FGL2's upregulation contributes to liver fibrosis and inflammation often in conjunction with another protein CD147. In autoimmune disorders the dysregulation of FGL2 can lead to excessive inflammatory responses impacting proteins like the interferon-gamma. Understanding FGL2's involvement in these diseases can inform therapeutic strategies targeting both coagulation and immune dysregulation.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May play a role in physiologic lymphocyte functions at mucosal sites.
See full target information FGL2
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Publications (6)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular sciences 25: PubMed39062880

2024

FGL2/FcγRIIB Signalling Mediates Arterial Shear Stress-Mediated Endothelial Cell Apoptosis: Implications for Coronary Artery Bypass Vein Graft Pathogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Molly L Jackson,Andrew R Bond,Raimondo Ascione,Jason L Johnson,Sarah J George

Frontiers in medicine 9:827695 PubMed35602471

2022

Identification and Validation of Immune Molecular Subtypes and Immune Landscape Based on Colon Cancer Cohort.

Applications

Unspecified application

Species

Unspecified reactive species

Wenqian Qi,Qian Zhang

Cell death & disease 13:130 PubMed35136014

2022

Stat4 rs7574865 polymorphism promotes the occurrence and progression of hepatocellular carcinoma via the Stat4/CYP2E1/FGL2 pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Caie Wang,Na Gao,Lukui Yang,Yuanyuan Guo,Yan Fang,Tong Wang,Chen Xu,Gui Fang Li,Jun Zhou,Yunfei Zhang,Qiang Wen,Hailing Qiao

Oncology letters 21:47 PubMed33281958

2020

Fibrinogen-like protein 2 promotes the accumulation of myeloid-derived suppressor cells in the hepatocellular carcinoma tumor microenvironment.

Applications

Unspecified application

Species

Unspecified reactive species

Bo-Qian Liu,Zhi-Ye Bao,Jia-Yi Zhu,Hao Liu

The journal of gene medicine 20:e3023 PubMed29756667

2018

Soluble Fgl2 restricts autoimmune hepatitis progression via suppressing Tc17 and conventional CD8+ T cell function.

Applications

Unspecified application

Species

Unspecified reactive species

Guo Ai,Weiming Yan,Haijing Yu,Fang Xiao,Dong Xi,Ke Ma,Jiaquan Huang,Xiaoping Luo,Xiaoyang Wan,Qin Ning

Molecular medicine reports 16:3445-3454 PubMed28713999

2017

Elevated fibrinogen‑like protein 2 in TNBS‑induced colitis mice: Association with Th17 and regulatory T cells.

Applications

Unspecified application

Species

Unspecified reactive species

Haihua Lin,Renpin Chen,Xuepei Jiang,Xiaoli Wu,Xielin Huang,Xiuli Dong,Xu Yang,Xiuqing Lin,Xin Chen,Xiangrong Chen,Zhiming Huang
View all publications
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