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AB224463

Anti-FHOD3 antibody

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(3 Publications)

Rabbit Polyclonal FHOD3 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human FHOD3 aa 650-800.

View Alternative Names

FHOS2, KIAA1695, FHOD3, FH1/FH2 domain-containing protein 3, Formactin-2, Formin homolog overexpressed in spleen 2, hFHOS2

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FHOD3 antibody (AB224463)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FHOD3 antibody (AB224463)

Paraffin-embedded human urinary bladder tissue stained for FHOD3 using ab224463 at 1/50 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human FHOD3 aa 650-800. The exact immunogen used to generate this antibody is proprietary information.

Q2V2M9

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The formin homology domain-containing protein 3 (FHOD3) is a member of the formin family of proteins. It acts as an actin nucleator and polymerization factor playing a role in cytoskeletal organization. FHOD3 has a molecular mass of approximately 154 kDa. This protein is found predominantly in cardiac and skeletal muscles indicating its key role in muscle tissue integrity and function. FHOD3 is particularly relevant in the heart where it influences sarcomere structure and dynamics.
Biological function summary

FHOD3 participates in the formation and maintenance of the actin cytoskeleton. It promotes the elongation of unbranched actin filaments by interacting directly with actin and other cytoskeletal components. FHOD3 operates as part of a complex that includes profilin a protein that catalyzes actin polymerization. This interaction aids in providing structural support necessary for muscle contraction and cell movement.

Pathways

One can note that FHOD3 integrates into cytoskeletal reorganization and signal transduction pathways. It works closely with Rho-GTPase signaling a pathway important for actin dynamics and cellular morphology. FHOD3 collaborates with proteins like RhoA to modulate actin filament assembly impacting processes such as cell shape and motility.

FHOD3 shows connections to cardiac conditions like hypertrophic cardiomyopathy and dilated cardiomyopathy. Mutations in the FHOD3 gene can disrupt normal cardiac actin filament function leading to impaired heart muscle contractility. Moreover FHOD3 interacts with cardiac troponins which are important for the regulation of muscle contraction highlighting its potential impact on heart disease progression and therapeutic targeting.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Actin-organizing protein that may cause stress fiber formation together with cell elongation (By similarity). Isoform 4 may play a role in actin filament polymerization in cardiomyocytes.
See full target information FHOD3
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

eLife 13: PubMed40663059

2025

Human formin FHOD3-mediated actin elongation is required for sarcomere integrity in cardiomyocytes.

Applications

Unspecified application

Species

Unspecified reactive species

Dylan A Valencia,Angela N Koeberlein,Haruko Nakano,Akos Rudas,Aanand A Patel,Airi Harui,Cassandra Spencer,Atsushi Nakano,Margot E Quinlan

Experimental dermatology 32:766-776 PubMed36772997

2023

SERPINB7 mutation causes Nagashima-type palmoplantar keratosis and its spatiotemporal expression in zebrafish.

Applications

Unspecified application

Species

Unspecified reactive species

Chen Lyu,Fan Zhang,Tingting Liu,Gongqi Yu,Kangkang Ge,Shengli Chen,Donglai Sheng,Yonghu Sun

Developmental cell 51:602-616.e12 PubMed31794718

2019

ERK1/2 Phosphorylation of FHOD Connects Signaling and Nuclear Positioning Alternations in Cardiac Laminopathy.

Applications

Unspecified application

Species

Unspecified reactive species

Susumu Antoku,Wei Wu,Leroy C Joseph,John P Morrow,Howard J Worman,Gregg G Gundersen
View all publications
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Product promise

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