AB58207

Anti-Fibrinogen antibody [1F2]

Name: Anti-Fibrinogen antibody [1F2] Mouse monoclonal (ab58207) | Abcam
Brand: Abcam Limited
SKU: AB58207
Price: 570 USD
Availability: InStock
Rating: 3 (1 reviews)

(1 Review)

(22 Publications)

Mouse Monoclonal Fibrinogen alpha chain antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 22 publications. Immunogen corresponding to Recombinant Fragment Protein within Human FGA aa 1-150.

View Alternative Names

Fibrinogen alpha chain, FGA

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Fibrinogen antibody [1F2] (AB58207)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Fibrinogen antibody [1F2] (AB58207)

Fibrinogen antibody (ab58207) used in immunohistochemistry at 1ug/ml on formalin fixed and paraffin embedded human hepatocellular carcinoma tissue.

This image was generated using the ascites version of the product.

Unknown

Western blot - Anti-Fibrinogen antibody [1F2] (AB58207)

Fibrinogen antibody (ab58207) at 1ug/lane + HeLa cell lysate at 25ug/lane.

This image was generated using the ascites version of the product.

All lanes:

Western blot - Anti-Fibrinogen antibody [1F2] (ab58207)

Predicted band size: 95 kDa

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Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

1F2

Isotype

IgG1

Light chain type

kappa

Carrier free

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human FGA aa 1-150. The exact immunogen used to generate this antibody is proprietary information.

P02671

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" } } }

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Product details

This product was changed from ascites to tissue culture supernatant on 12th of March 2019. Please note that the dilutions may need to be adjusted accordingly. If you have any questions, please do not hesitate to contact our scientific support team.

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Properties and storage information

Form

Liquid

Purity

Tissue culture supernatant

Storage buffer

pH: 7.4

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways.

See full target information FGA

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Publications (22)

Recent publications for all applications. Explore the full list and refine your search

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism :271678X251338953 PubMed40770921

2025

Fibrinogen contributes to myelin deficit and cognitive impairment in aged mice after anesthesia and surgery.

Applications

Unspecified application

Species

Unspecified reactive species

Xueji Wang,Sufang Jiang,Tianyu Cao,Peiying Huang,Lichao Di,Jiaqi Li,Lining Huang

Research and practice in thrombosis and haemostasis 9:102666 PubMed39959636

2025

Histologic evidence of neutrophil extracellular traps and fibrin(ogen) deposition in liver biopsies from patients with inflammatory liver disease.

Applications

Unspecified application

Species

Unspecified reactive species

Fien A von Meijenfeldt,Ton Lisman,Alessandra Pacheco,Yoh Zen,William Bernal

European stroke journal 10:892-901 PubMed39910895

2025

C-reactive protein expression in acute ischemic stroke blood clots: Implications for etiology.

Applications

Unspecified application

Species

Unspecified reactive species

Wenyi Liu,Cansu Sahin,Nazan Güner Sak,Alice Giraud,Pierluca Messina,Franz Bozsak,Jean Darcourt,Federico Sacchetti,Anne-Christine Januel,Guillaume Bellanger,Jorge Pagola,Jesus Juega,Hirotoshi Imamura,Tsuyoshi Ohta,Laurent Spelle,Vanessa Chalumeau,Uros Mircic,Predrag Stanarčević,Ivan Vukašinović,Marc Ribo,Nobuyuki Sakai,Christophe Cognard,Karen Doyle

Cell death & disease 15:258 PubMed38609388

2024

Endothelial DR6 in blood-brain barrier malfunction in Alzheimer's disease.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaomin Huang,Junhua Qi,Yixun Su,Ying Zhou,Qi Wang,Taida Huang,Dongdong Xue,Yunxin Zeng,Alexei Verkhratsky,Benjie Zhou,Hui Chen,Chenju Yi

BMC neurology 24:90 PubMed38454378

2024

High thrombin-activatable fibrinolysis inhibitor expression in thrombi from stroke patients in elevated estrogen states.

Applications

Unspecified application

Species

Unspecified reactive species

Tamanna Agarwal,Oana Madalina Mereuta,Sherief Ghozy,Jorge L Arturo Larco,Cem Bilgin,Ram Kadirvel,Waleed Brinjikji,David F Kallmes

Acta neuropathologica 146:803-815 PubMed37897548

2023

The neuropathology of intimate partner violence.

Applications

Unspecified application

Species

Unspecified reactive species

Kristen Dams-O'Connor,Alan C Seifert,John F Crary,Bradley N Delman,Marc R Del Bigio,Gabor G Kovacs,Edward B Lee,Amber L Nolan,Ariel Pruyser,Enna Selmanovic,William Stewart,Emma Woodoff-Leith,Rebecca D Folkerth

iScience 26:108289 PubMed38034352

2023

Neutrophil extracellular traps and DNases orchestrate formation of peritoneal adhesions.

Applications

Unspecified application

Species

Unspecified reactive species

Julia Elrod,Annika Heuer,Jasmin Knopf,Janina Schoen,Lavinia Schönfeld,Magdalena Trochimiuk,Carolin Stiel,Birgit Appl,Laia Pagerols Raluy,Ceren Saygi,Leticija Zlatar,Sami Hosari,Dmytro Royzman,Thomas H Winkler,Günter Lochnit,Moritz Leppkes,Robert Grützmann,Georg Schett,Christian Tomuschat,Konrad Reinshagen,Martin Herrmann,Tobias A Fuchs,Michael Boettcher

Journal of neuropathology and experimental neurology 82:283-295 PubMed36847705

2023

Neuropathological features of SARS-CoV-2 delta and omicron variants.

Applications

Unspecified application

Species

Unspecified reactive species

Erica Normandin,Navid Valizadeh,Emily A Rudmann,Rockib Uddin,Sabrina T Dobbins,Bronwyn L MacInnis,Robert F Padera,Katherine J Siddle,Jacob E Lemieux,Pardis C Sabeti,Shibani S Mukerji,Isaac H Solomon

Neurology 100:624-628 PubMed36526429

2022

Detection of SARS-CoV-2 Nucleocapsid and Microvascular Disease in the Brain: A Case Report.

Applications

Unspecified application

Species

Unspecified reactive species

Catherine DeMarino,Myoung-Hwa Lee,Maria Cowen,Joseph P Steiner,Sara Inati,Ashish H Shah,Kareem A Zaghloul,Avindra Nath

EBioMedicine 84:104275 PubMed36152520

2022

Endothelial caveolin-1 regulates cerebral thrombo-inflammation in acute ischemia/reperfusion injury.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaohao Zhang,Pengyu Gong,Ying Zhao,Ting Wan,Kang Yuan,Yunyun Xiong,Min Wu,Mingming Zha,Yunzi Li,Teng Jiang,Xinfeng Liu,Ruidong Ye,Yi Xie,Gelin Xu

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Fibrinogen antibody [1F2]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Fibrinogen antibody [1F2] (AB58207)

Western blot - Anti-Fibrinogen antibody [1F2] (AB58207)

Key facts

Host species

Clonality

Clone number

Isotype

Light chain type

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Product details

Properties and storage information

Form

Purity

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Product protocols

Target data

Publications (22)

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