Goat Polyclonal Fibrinogen alpha chain antibody. Suitable for IHC-P and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human FGA.
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Publications
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- Journal of biomedical materials research. Part B, Applied biomaterials 110:527-5342021Enhancement of the anticoagulant capacity of polyvinyl chloride tubing for cardiopulmonary bypass circuit using aluminum oxide nanoscale coating applied through atomic layer deposition.Applications:Unspecified applicationReactive species:Unspecified reactive speciesChen-Chie Wang,Li-Chun Wang,Kai-Chiang Yang,Miin-Jang Chen,Hsin-Chih Lin,Yin-Yi HanPubMed 34492134
- Biomaterials 273:1208272021PEGylated nanoparticle albumin-bound steroidal ginsenoside derivatives ameliorate SARS-CoV-2-mediated hyper-inflammatory responses.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHee Ho Park,Hyelim Kim,Han Sol Lee,Eun U Seo,Ji-Eun Kim,Jee-Hyun Lee,Yong-Hyeon Mun,So-Yeol Yoo,Jiseon An,Mi-Young Yun,Nae-Won Kang,Dae-Duk Kim,Dong Hee Na,Kyung Soo Hong,Jong Geol Jang,June Hong Ahn,Jong-Sup Bae,Gyu Yong Song,Jae-Young Lee,Hong Nam Kim,Wonhwa LeePubMed 33910079
- American journal of physiology. Renal physiology 315:F1283-F12942018Intrarenal Toll-like receptor 4 and Toll-like receptor 2 expression correlates with injury in antineutrophil cytoplasmic antibody-associated vasculitis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKim M O'Sullivan et. al.PubMed 29923769
- EBioMedicine 32:215-2222018Recellularization of Decellularized Venous Grafts Using Peripheral Blood: A Critical Evaluation.
Key facts
- Isotype
- IgG
- Host species
- Goat
- Storage buffer
pH: 7.2
Preservative: 0.01% Sodium azide
Constituents: 0.88% Sodium chloride, 0.424% Tripotassium orthophosphate- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human FGA. The exact immunogen used to generate this antibody is proprietary information. Database link P02671
Consider this alternative
Reactivity data
Select an application| IHC-P | |
|---|---|
| Human | Tested |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 2.5 µg/mL | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
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Target data
Function
Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways.
Alternative names
Fibrinogen alpha chain, FGA
Recommended products
Goat Polyclonal Fibrinogen alpha chain antibody. Suitable for IHC-P and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human FGA.
Key facts
- Isotype
- IgG
- Host species
- Goat
- Storage buffer
pH: 7.2
Preservative: 0.01% Sodium azide
Constituents: 0.88% Sodium chloride, 0.424% Tripotassium orthophosphate- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human FGA. The exact immunogen used to generate this antibody is proprietary information. Database link P02671
- Purity
- IgG fraction
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
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Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Fibrinogen antibody (ab118488)
ab118488 at 2.5μg/ml staining Fibrinogen in Formalin-fixed, Paraffin-embedded Human kidney tissue by Immunohistochemistry, followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Fibrinogen antibody (ab118488)
ab118488 at 2.5μg/ml staining Fibrinogen in Formalin-fixed, Paraffin-embedded Human liver tissue by Immunohistochemistry, followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.
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