AB118533

Anti-Fibrinogen antibody

(2 Reviews)

(14 Publications)

Sheep Polyclonal Fibrinogen alpha chain antibody. Suitable for IHC-P and reacts with Human samples. Cited in 14 publications. Immunogen corresponding to Native Full Length Protein corresponding to Human FGA.

View Alternative Names

Fibrinogen alpha chain, FGA

1 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Fibrinogen antibody (AB118533)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Fibrinogen antibody (AB118533)

Human Placenta tissue (formalin-fixed, paraffin-embedded) stained with ab118533 at 5 µg/ml followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Key facts

Host species

Sheep

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Native Full Length Protein corresponding to Human FGA.

P02671

Specificity

ab118533 shows minimal cross-reactivity with related serum proteins.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Product details

Store undiluted.

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein G

Storage buffer

pH: 7.4 Preservative: 0.09% Sodium azide Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways.

See full target information FGA

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Publications (14)

Recent publications for all applications. Explore the full list and refine your search

Acta neuropathologica 149:1 PubMed39680199

2024

TAM receptors mediate the Fpr2-driven pain resolution and fibrinolysis after nerve injury.

Applications

Unspecified application

Species

Unspecified reactive species

Beate Hartmannsberger,Adel Ben-Kraiem,Sofia Kramer,Carolina Guidolin,Ida Kazerani,Kathrin Doppler,Dominique Thomas,Robert Gurke,Marco Sisignano,Pranav P Kalelkar,Andrés J García,Paula V Monje,Michael Sammeth,Asma Nusrat,Alexander Brack,Susanne M Krug,Claudia Sommer,Heike L Rittner

Aging and disease : PubMed38377019

2024

Neuron Derived Cold-Inducible RNA-Binding Protein Promotes NETs Formation to Exacerbate Brain Endothelial Barrier Disruption after Ischemic Stroke.

Applications

Unspecified application

Species

Unspecified reactive species

Zhifang Li,Shuai Sun,Qinghui Xiao,Senwei Tan,Huijuan Jin,Bo Hu

Neurology(R) neuroimmunology & neuroinflammation 10: PubMed37236806

2023

Immunohistologic Features of Cerebral Venous Thrombosis Due to Vaccine-Induced Immune Thrombotic Thrombocytopenia.

Applications

Unspecified application

Species

Unspecified reactive species

Thomas Geeraerts,Céline Guilbeau-Frugier,Cédric Garcia,Vincent Memier,Nicolas Raposo,Fabrice Bonneville,Céline Gales,Jean Darcourt,Sophie Voisin,Agnès Ribes,Marie Piel-Julian,Fanny Bounes,Jean François Albucher,Franck-Emmanuel Roux,Jacques Izopet,Norbert Telmon,Jean Marc Olivot,Pierre Sié,Jan Bauer,Bernard Payrastre,Roland S Liblau

Nature protocols 17:378-401 PubMed35022622

2022

IBEX: an iterative immunolabeling and chemical bleaching method for high-content imaging of diverse tissues.

Applications

mIHC

Species

Human

Andrea J Radtke,Colin J Chu,Ziv Yaniv,Li Yao,James Marr,Rebecca T Beuschel,Hiroshi Ichise,Anita Gola,Juraj Kabat,Bradley Lowekamp,Emily Speranza,Joshua Croteau,Nishant Thakur,Danny Jonigk,Jeremy L Davis,Jonathan M Hernandez,Ronald N Germain

Frontiers in aging neuroscience 13:735524 PubMed34707490

2021

Uncovering Disease Mechanisms in a Novel Mouse Model Expressing Humanized APOEε4 and Trem2*R47H.

Applications

Unspecified application

Species

Unspecified reactive species

Kevin P Kotredes,Adrian Oblak,Ravi S Pandey,Peter Bor-Chian Lin,Dylan Garceau,Harriet Williams,Asli Uyar,Rita O'Rourke,Sarah O'Rourke,Cynthia Ingraham,Daria Bednarycek,Melisa Belanger,Zackary Cope,Kate E Foley,Benjamin A Logsdon,Lara M Mangravite,Stacey J Sukoff Rizzo,Paul R Territo,Gregory W Carter,Michael Sasner,Bruce T Lamb,Gareth R Howell

Neuron 108:1130-1145.e5 PubMed33086038

2020

Wnt-Dependent Oligodendroglial-Endothelial Interactions Regulate White Matter Vascularization and Attenuate Injury.

Applications

Unspecified application

Species

Unspecified reactive species

Manideep Chavali,Maria José Ulloa-Navas,Pedro Pérez-Borredá,Jose Manuel Garcia-Verdugo,Patrick S McQuillen,Eric J Huang,David H Rowitch

Cell research 30:1109-1126 PubMed32690901

2020

Comparative analysis of cell lineage differentiation during hepatogenesis in humans and mice at the single-cell transcriptome level.

Applications

Unspecified application

Species

Unspecified reactive species

Xin Wang,Li Yang,Yan-Chun Wang,Zi-Ran Xu,Ye Feng,Jing Zhang,Yi Wang,Cheng-Ran Xu

Cancer cell 37:800-817.e7 PubMed32516590

2020

Reduction of Liver Metastasis Stiffness Improves Response to Bevacizumab in Metastatic Colorectal Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Ying Shen,Xiaohong Wang,Junyan Lu,Martin Salfenmoser,Naita Maren Wirsik,Nikolai Schleussner,Andrea Imle,Aida Freire Valls,Praveen Radhakrishnan,Jie Liang,Guoliang Wang,Thomas Muley,Martin Schneider,Carmen Ruiz de Almodovar,Alba Diz-Muñoz,Thomas Schmidt

The Journal of cell biology 217:2813-2830 PubMed29858212

2018

Vav3-induced cytoskeletal dynamics contribute to heterotypic properties of endothelial barriers.

Applications

Unspecified application

Species

Unspecified reactive species

Georg Hilfenhaus,Dai Phuong Nguyen,Jonathan Freshman,Divya Prajapati,Feiyang Ma,Dana Song,Safiyyah Ziyad,Myriam Cuadrado,Matteo Pellegrini,Xosé R Bustelo,M Luisa Iruela-Arispe

Cancer cell 33:874-889.e7 PubMed29681511

2018

A Glial Signature and Wnt7 Signaling Regulate Glioma-Vascular Interactions and Tumor Microenvironment.

Applications

Unspecified application

Species

Unspecified reactive species

Amelie Griveau,Giorgio Seano,Samuel J Shelton,Robert Kupp,Arman Jahangiri,Kirsten Obernier,Shanmugarajan Krishnan,Olle R Lindberg,Tracy J Yuen,An-Chi Tien,Jennifer K Sabo,Nancy Wang,Ivy Chen,Jonas Kloepper,Louis Larrouquere,Mitrajit Ghosh,Itay Tirosh,Emmanuelle Huillard,Arturo Alvarez-Buylla,Michael C Oldham,Anders I Persson,William A Weiss,Tracy T Batchelor,Anat Stemmer-Rachamimov,Mario L Suvà,Joanna J Phillips,Manish K Aghi,Shwetal Mehta,Rakesh K Jain,David H Rowitch

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Anti-Fibrinogen antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Fibrinogen antibody (AB118533)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Specificity

Reactivity data

Product details

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Product protocols

Target data

Publications (14)

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