AB27913

Anti-Fibrinogen antibody

Name: Anti-Fibrinogen antibody (ab27913) | Abcam
Brand: Abcam Limited
SKU: AB27913
Price: 435 USD
Availability: InStock
Rating: 5 (2 reviews)

(2 Reviews)

(17 Publications)

Rabbit Polyclonal Fibrinogen beta chain antibody. Suitable for ELISA, WB, IHC-P and reacts with Mouse samples. Cited in 17 publications. Immunogen corresponding to Native Full Length Protein corresponding to Mouse Fgb.

View Alternative Names

Fibrinogen beta chain, Fgb

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse

Applications

ELISA, IHC-P, WB

applications

Immunogen

Native Full Length Protein corresponding to Mouse Fgb.

Q8K0E8

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purity

Whole antiserum

Storage buffer

Constituents: Whole serum

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-80°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways.

See full target information Fgb

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Publications (17)

Recent publications for all applications. Explore the full list and refine your search

Stroke 55:2885-2895 PubMed39474674

2024

Effects of Haptoglobin on Early Brain Injury, Vasospasm, and Lymphatic Drainage After Subarachnoid Hemorrhage in Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Fumihiro Kawakita,Hideki Nakajima,Yume Suzuki,Mai Nampei,Hiroki Oinaka,Hidenori Suzuki

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 45:617-629 PubMed39053491

2024

Pericyte response to ischemic stroke precedes endothelial cell death and blood-brain barrier breakdown.

Applications

Unspecified application

Species

Unspecified reactive species

Michaela Roth,Robert Carlsson,Carolina Buizza,Andreas Enström,Gesine Paul

Cardiovascular diabetology 23:88 PubMed38424560

2024

The SGLT2 inhibitor Empagliflozin promotes post-stroke functional recovery in diabetic mice.

Applications

Unspecified application

Species

Unspecified reactive species

Ellen Vercalsteren,Dimitra Karampatsi,Carolina Buizza,Thomas Nyström,Thomas Klein,Gesine Paul,Cesare Patrone,Vladimer Darsalia

ACS pharmacology & translational science 6:1015-1027 PubMed37470022

2023

Dasatinib Ointment Promotes Healing of Murine Excisional Skin Wound.

Applications

Unspecified application

Species

Unspecified reactive species

Surasak Wichaiyo,Saovaros Svasti,Arnatchai Maiuthed,Pattarawit Rukthong,Arman Syah Goli,Noppawan Phumala Morales

Frontiers in cardiovascular medicine 9:974759 PubMed35966530

2022

Neutrophil circadian rhythm is associated with different outcomes of acute kidney injury due to cholesterol crystal embolism.

Applications

Unspecified application

Species

Unspecified reactive species

Chongxu Shi,Danyang Zhao,Lyuben Lyubenov,Manga Motrapu,Na Li,Stefanie Steiger,Elmina Mammadova-Bach,Luying Yang,Dong Liu,Hans-Joachim Anders

Cellular and molecular life sciences : CMLS 79:240 PubMed35416530

2022

Novel contact-kinin inhibitor sylvestin targets thromboinflammation and ameliorates ischemic stroke.

Applications

Unspecified application

Species

Unspecified reactive species

Zhiye Zhang,Chuanbin Shen,Mingqian Fang,Yajun Han,Chengbo Long,Weihui Liu,Min Yang,Ming Liu,Dengdeng Zhang,Qiqi Cao,Xue Chen,Yaqun Fang,Qiumin Lu,Zongliu Hou,Yaxiong Li,Zhenze Liu,Xi Lei,Heyu Ni,Ren Lai

American journal of physiology. Lung cellular and molecular physiology 322:L593-L606 PubMed35200041

2022

Fibrinogen mediates cadmium-induced macrophage activation and serves as a predictor of cadmium exposure in chronic obstructive pulmonary disease.

Applications

Unspecified application

Species

Unspecified reactive species

Fu Jun Li,Ranu Surolia,Pooja Singh,Kevin G Dsouza,Crystal T Stephens,Zheng Wang,Rui-Ming Liu,Sejong Bae,Young-Il Kim,Mohammad Athar,Mark T Dransfield,Veena B Antony

Journal of thrombosis and haemostasis : JTH 19:3154-3167 PubMed34402195

2021

Dasatinib induces loss of vascular integrity and promotes cutaneous wound repair in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Surasak Wichaiyo,Saovaros Svasti,Wasu Supharattanasitthi,Noppawan Phumala Morales

American journal of clinical and experimental urology 9:18-31 PubMed33816691

2021

Platelet TSP-1 controls prostate cancer-induced osteoclast differentiation and bone marrow-derived cell mobilization through TGFβ-1.

Applications

Unspecified application

Species

Unspecified reactive species

Bethany A Kerr,Koran S Harris,Lihong Shi,Jeffrey S Willey,David R Soto-Pantoja,Tatiana V Byzova

Molecular metabolism 41:101046 PubMed32599075

2020

Muscle NAD depletion and Serpina3n as molecular determinants of murine cancer cachexia-the effects of blocking myostatin and activins.

Applications

Unspecified application

Species

Unspecified reactive species

J J Hulmi,F Penna,N Pöllänen,T A Nissinen,J Hentilä,L Euro,J H Lautaoja,R Ballarò,R Soliymani,M Baumann,O Ritvos,E Pirinen,M Lalowski

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Fibrinogen antibody

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purity

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Product protocols

Target data

Publications (17)

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