AB232793

Anti-Fibrinogen beta chain antibody

Name: Anti-Fibrinogen beta chain antibody (ab232793) | Abcam
Brand: Abcam Limited
SKU: AB232793
Price: 525 USD
Availability: InStock

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(4 Publications)

Rabbit Polyclonal Fibrinogen beta chain antibody. Suitable for WB, IHC-P and reacts with Human, Recombinant full length protein - Human, Mouse, Pig samples. Cited in 4 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human Fibrinogen beta chain.

View Alternative Names

Fibrinogen beta chain, FGB

3 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Fibrinogen beta chain antibody (AB232793)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Fibrinogen beta chain antibody (AB232793)

Formalin-fixed, paraffin-embedded human liver tissue stained for Fibrinogen beta chain using ab232793 at 20 μg/ml in immunohistochemical analysis. DAB staining.

Supplier Data

Western blot - Anti-Fibrinogen beta chain antibody (AB232793)

All lanes:

Western blot - Anti-Fibrinogen beta chain antibody (ab232793) at 2 µg

All lanes:

Recombinant human Fibrinogen beta chain protein

Secondary

All lanes:

HRP-Linked Guinea pig anti-Rabbit at 1/2000 dilution

Predicted band size: 56 kDa

false

Unknown

Western blot - Anti-Fibrinogen beta chain antibody (AB232793)

All lanes:

Western blot - Anti-Fibrinogen beta chain antibody (ab232793) at 2 µg/mL

Lane 1:

Human urine

Lane 2:

Mouse heart lysate

Lane 3:

Pig brain lysate

Secondary

All lanes:

HRP-Linked Guinea pig anti-Rabbit at 1/2000 dilution

Predicted band size: 56 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse, Human, Pig

Applications

WB, IHC-P

applications

Immunogen

Recombinant Full Length Protein corresponding to Human Fibrinogen beta chain.

P02675

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Pig": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Recombinant full length protein - Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Purification notes

Antigen-specific affinity chromatography followed by Protein A affinity chromatography.

Storage buffer

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.

See full target information Fibrinogen beta chain

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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Gene therapy 29:418-424 PubMed34226687

2021

rAAV-based and intraprostatically delivered miR-34a therapeutics for efficient inhibition of prostate cancer progression.

Applications

Unspecified application

Species

Unspecified reactive species

Jianzhong Ai,Jia Li,Qin Su,Hong Ma,Ran He,Qiang Wei,Hong Li,Guangping Gao

Medicine 98:e17031 PubMed31689742

2019

Alterations in complement and coagulation pathways of human placentae subjected to in vitro fertilization and embryo transfer in the first trimester.

Applications

Unspecified application

Species

Unspecified reactive species

Liang Zhao,Lifang Sun,Xiuli Zheng,Jingfang Liu,Rong Zheng,Rui Yang,Ying Wang

Clinical and experimental medicine 19:557-564 PubMed31576477

2019

FGB and FGG derived from plasma exosomes as potential biomarkers to distinguish benign from malignant pulmonary nodules.

Applications

Unspecified application

Species

Unspecified reactive species

Muyu Kuang,Yizhou Peng,Xiaoting Tao,Zilang Zhou,Hengyu Mao,Lingdun Zhuge,Yihua Sun,Huibiao Zhang

Experimental cell research 382:111466 PubMed31201813

2019

SIRT1 downregulated FGB expression to inhibit RCC tumorigenesis by destabilizing STAT3.

Applications

Unspecified application

Species

Unspecified reactive species

Yanbing Chen,Ying Zhu,Yanling Sheng,Juhua Xiao,Yu Xiao,Na Cheng,Yong Chai,Xiaoping Wu,Shouhua Zhang,Tianxin Xiang

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Fibrinogen beta chain antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Fibrinogen beta chain antibody (AB232793)

Western blot - Anti-Fibrinogen beta chain antibody (AB232793)

Western blot - Anti-Fibrinogen beta chain antibody (AB232793)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Product protocols

Target data

Publications (4)

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