AB119948

Anti-Fibrinogen gamma chain antibody [5A6]

Name: Anti-Fibrinogen gamma chain antibody [5A6] (ab119948) | Abcam
Brand: Abcam Limited
SKU: AB119948
Price: 410 USD
Availability: InStock
Rating: 5 (1 reviews)

(1 Review)

(12 Publications)

Mouse Monoclonal Fibrinogen gamma chain antibody. Suitable for ELISA, WB, ICC/IF and reacts with Synthetic peptide, Mouse, Recombinant full length protein, Human samples. Cited in 12 publications. Immunogen corresponding to Recombinant Fragment Protein within Human FGG aa 200 to C-terminus.

View Alternative Names

PRO2061, FGG, Fibrinogen gamma chain

3 Images

Immunocytochemistry/ Immunofluorescence - Anti-Fibrinogen gamma chain antibody [5A6] (AB119948)

ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-Fibrinogen gamma chain antibody [5A6] (AB119948)

Immunofluorescence analysis of NIH3T3 cells using ab119948 at a dilution of 1/200 (green). Blue : DRAQ5 fluorescent DNA dye. Red : Actin filaments have been labeled with Alexa Fluor-555 phalloidin.

ELISA - Anti-Fibrinogen gamma chain antibody [5A6] (AB119948)

ELISA

Unknown

ELISA - Anti-Fibrinogen gamma chain antibody [5A6] (AB119948)

ELISA, using ab119948 at a dilution of 1/10000.

Unknown

Western blot - Anti-Fibrinogen gamma chain antibody [5A6] (AB119948)

All lanes:

Western blot - Anti-Fibrinogen gamma chain antibody [5A6] (ab119948) at 1/500 dilution

All lanes:

Recombinant Fibrinogen gamma chain protein

Predicted band size: 52 kDa

false

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

5A6

Isotype

IgG2b

Carrier free

Reacts with

Mouse, Human

Applications

ELISA, WB, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human FGG aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P02679

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ELISA-species-checked": "predicted", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "1/200 - 1/1000", "ICCIF-species-notes": "" }, "Mouse": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/200 - 1/1000", "ICCIF-species-notes": "" }, "Recombinant full length protein": { "ELISA-species-checked": "notRecommended", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Synthetic peptide": { "ELISA-species-checked": "testedAndGuaranteed", "ELISA-species-dilution-info": "1/10000", "ELISA-species-notes": "", "WB-species-checked": "notRecommended", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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Product details

This product was changed from ascites to supernatant. Lot no's high than GR240839-12 are from Tissue Culture Supernatant

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein G

Purification notes

Purified from tissue culture supernatant.

Storage buffer

Preservative: 0.05% Sodium azide Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix. Has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.

See full target information FGG

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Publications (12)

Recent publications for all applications. Explore the full list and refine your search

British journal of pharmacology 182:3577-3593 PubMed40194543

2025

Fibrin induces infiltration of macrophages and neutrophils via integrin αMβ2 and triggers aortic dissection.

Applications

Unspecified application

Species

Unspecified reactive species

Jie Li,Jixiu Zhang,Lingwei Zou,Meifang Cao,Zhonghui Zhu,Li Yu,Min Zhou,Weiguo Fu,Zhihui Dong,Huiyuan Gao,Baohong Jiang

Artificial organs 48:734-742 PubMed38380722

2024

The effect of ultrasound-assisted thrombolysis studied in blood-on-a-chip.

Applications

Unspecified application

Species

Unspecified reactive species

Yan Li,Yongjian Li,Haosheng Chen

Cell death & disease 14:717 PubMed37923734

2023

GRSF1 antagonizes age-associated hypercoagulability via modulation of fibrinogen mRNA stability.

Applications

Unspecified application

Species

Unspecified reactive species

Doudou Liu,Chenzhong Xu,Ze Gong,Yijie Zhao,Zhiqiang Fang,Xiaoli Rao,Qingyu Chen,Guodong Li,Wei Kong,Jun Chen

Nature communications 14:4960 PubMed37620307

2023

Citrullinated fibrinogen-SAAs complex causes vascular metastagenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Yibing Han,Takeshi Tomita,Masayoshi Kato,Norihiro Ashihara,Yumiko Higuchi,Hisanori Matoba,Weiyi Wang,Hikaru Hayashi,Yuji Itoh,Satoshi Takahashi,Hiroshi Kurita,Jun Nakayama,Nobuo Okumura,Sachie Hiratsuka

Medical oncology (Northwood, London, England) 40:10 PubMed36352295

2022

Fibrinogen promotes gallbladder cancer cell metastasis and extravasation by inducing ICAM1 expression.

Applications

Unspecified application

Species

Unspecified reactive species

Chengkai Jiang,Yang Li,Yongsheng Li,Liguo Liu,Xu-An Wang,Wenguang Wu,Runfa Bao,Hao Weng,Maolan Li,Yajun Geng,Yijun Shu,Yingbin Liu

Translational stroke research 14:752-765 PubMed35962915

2022

The Role of Neutrophil Extracellular Traps in Early Microthrombosis and Brain Injury After Subarachnoid Hemorrhage in Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaoke Hao,Zongwei Zeng,Liang Liang,Zhou Feng,Wu Li,Binyuan Xiong,Peiwen Guo,Qiang Zhang,Yujie Chen,Hua Feng,Zhi Chen

Electrophoresis 43:1784-1798 PubMed35753078

2022

cyc-DEP: Cyclic immunofluorescence profiling of particles collected using dielectrophoresis.

Applications

Unspecified application

Species

Unspecified reactive species

Kyle T Gustafson,Zeynep Sayar,Hillary Le,Steven L Gustafson,Austin Gower,Augusta Modestino,Stuart Ibsen,Michael J Heller,Sadik Esener,Sebnem E Eksi

Clinical and experimental medicine 19:557-564 PubMed31576477

2019

FGB and FGG derived from plasma exosomes as potential biomarkers to distinguish benign from malignant pulmonary nodules.

Applications

Unspecified application

Species

Unspecified reactive species

Muyu Kuang,Yizhou Peng,Xiaoting Tao,Zilang Zhou,Hengyu Mao,Lingdun Zhuge,Yihua Sun,Huibiao Zhang

Molecular medicine reports 16:272-280 PubMed28534980

2017

A proteomic analysis identifies candidate early biomarkers to predict ovarian hyperstimulation syndrome in polycystic ovarian syndrome patients.

Applications

Unspecified application

Species

Unspecified reactive species

Lan Wu,Yazhou Sun,Jun Wan,Ting Luan,Qing Cheng,Yong Tan

eLife 6: PubMed28092265

2017

The fibronectin synergy site re-enforces cell adhesion and mediates a crosstalk between integrin classes.

Applications

Unspecified application

Species

Unspecified reactive species

Maria Benito-Jardón,Sarah Klapproth,Irene Gimeno-LLuch,Tobias Petzold,Mitasha Bharadwaj,Daniel J Müller,Gabriele Zuchtriegel,Christoph A Reichel,Mercedes Costell

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Fibrinogen gamma chain antibody [5A6]

Immunocytochemistry/ Immunofluorescence - Anti-Fibrinogen gamma chain antibody [5A6] (AB119948)

ELISA - Anti-Fibrinogen gamma chain antibody [5A6] (AB119948)

Western blot - Anti-Fibrinogen gamma chain antibody [5A6] (AB119948)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

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Reactivity data

Product details

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Product protocols

Target data

Publications (12)

Product promise