Mouse Monoclonal Fibrinogen gamma chain antibody. Suitable for ELISA, WB, ICC/IF and reacts with Synthetic peptide, Mouse, Recombinant full length protein, Human samples. Cited in 9 publications. Immunogen corresponding to Recombinant Fragment Protein within Human FGG aa 200-450.
Images
![Western blot - Anti-Fibrinogen gamma chain antibody [5A6] (AB119948), expandable thumbnail](https://content.abcam.com/products/images/fibrinogen-gamma-chain-antibody-5a6-ab119948--western-blot-img63371.jpg/_jcr_content/renditions/webp-475.webp "Western blot - Anti-Fibrinogen gamma chain antibody [5A6] (AB119948)")
![Immunocytochemistry/ Immunofluorescence - Anti-Fibrinogen gamma chain antibody [5A6] (AB119948), expandable thumbnail](https://content.abcam.com/products/images/fibrinogen-gamma-chain-antibody-5a6-ab119948--immunocytochemistry-immunofluorescence-img93444.jpg/_jcr_content/renditions/webp-475.webp "Immunocytochemistry/ Immunofluorescence - Anti-Fibrinogen gamma chain antibody [5A6] (AB119948)")
![ELISA - Anti-Fibrinogen gamma chain antibody [5A6] (AB119948), expandable thumbnail](https://content.abcam.com/products/images/fibrinogen-gamma-chain-antibody-5a6-ab119948--elisa-img415654.jpg/_jcr_content/renditions/webp-475.webp "ELISA - Anti-Fibrinogen gamma chain antibody [5A6] (AB119948)")
Publications
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- Cell death & disease 14:7172023GRSF1 antagonizes age-associated hypercoagulability via modulation of fibrinogen mRNA stability.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDoudou Liu,Chenzhong Xu,Ze Gong,Yijie Zhao,Zhiqiang Fang,Xiaoli Rao,Qingyu Chen,Guodong Li,Wei Kong,Jun ChenPubMed 37923734
- Medical oncology (Northwood, London, England) 40:102022Fibrinogen promotes gallbladder cancer cell metastasis and extravasation by inducing ICAM1 expression.Applications:Unspecified applicationReactive species:Unspecified reactive speciesChengkai Jiang,Yang Li,Yongsheng Li,Liguo Liu,Xu-An Wang,Wenguang Wu,Runfa Bao,Hao Weng,Maolan Li,Yajun Geng,Yijun Shu,Yingbin LiuPubMed 36352295
- Translational stroke research 14:752-7652022The Role of Neutrophil Extracellular Traps in Early Microthrombosis and Brain Injury After Subarachnoid Hemorrhage in Mice.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXiaoke Hao,Zongwei Zeng,Liang Liang,Zhou Feng,Wu Li,Binyuan Xiong,Peiwen Guo,Qiang Zhang,Yujie Chen,Hua Feng,Zhi ChenPubMed 35962915
- Electrophoresis 43:1784-17982022cyc-DEP: Cyclic immunofluorescence profiling of particles collected using dielectrophoresis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKyle T Gustafson,Zeynep Sayar,Hillary Le,Steven L Gustafson,Austin Gower,Augusta Modestino,Stuart Ibsen,Michael J Heller,Sadik Esener,Sebnem E EksiPubMed 35753078
- Clinical and experimental medicine 19:557-5642019FGB and FGG derived from plasma exosomes as potential biomarkers to distinguish benign from malignant pulmonary nodules.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMuyu Kuang et. al.PubMed 31576477
- Molecular medicine reports 16:272-2802017A proteomic analysis identifies candidate early biomarkers to predict ovarian hyperstimulation syndrome in polycystic ovarian syndrome patients.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLan Wu et. al.PubMed 28534980
- eLife 6:2017The fibronectin synergy site re-enforces cell adhesion and mediates a crosstalk between integrin classes.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMaria Benito-Jardón,Sarah Klapproth,Irene Gimeno-LLuch,Tobias Petzold,Mitasha Bharadwaj,Daniel J Müller,Gabriele Zuchtriegel,Christoph A Reichel,Mercedes CostellPubMed 28092265
- Journal of neuroscience methods 239:65-742014A novel atherothrombotic model of ischemic stroke induced by injection of collagen into the cerebral vasculature.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKathryn J Schunke,Thomas K Toung,Jian Zhang,Arvind P Pathak,Jiadi Xu,Jiangyang Zhang,Raymond C Koehler,Nauder FaradayPubMed 25314906
- Acta biomaterialia 10:1940-542013Immobilization of heparin/poly-(L)-lysine nanoparticles on dopamine-coated surface to create a heparin density gradient for selective direction of platelet and vascular cells behavior.Applications:Unspecified applicationReactive species:Unspecified reactive speciesTao Liu,Yang Liu,Yuan Chen,Shihui Liu,Manfred F Maitz,Xue Wang,Kun Zhang,Jian Wang,Yuan Wang,Junying Chen,Nan HuangPubMed 24342042
Key facts
- Isotype
IgG2b
- Host species
Mouse
- Storage buffer
Preservative: 0.05% Sodium azide
Constituents: PBS- Form
Liquid
- Clonality
Monoclonal
Immunogen
- Recombinant Fragment Protein within Human FGG aa 200-450. The exact immunogen used to generate this antibody is proprietary information. Database link P02679
Reactivity data
Select an application| ELISA | WB | ICC/IF | |
|---|---|---|---|
| Human | Predicted | Expected | Expected |
| Mouse | Expected | Expected | Tested |
| Recombinant full length protein | Not recommended | Tested | Not recommended |
| Synthetic peptide | Tested | Not recommended | Not recommended |
ELISA
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Synthetic peptide | Dilution info 1/10000 | Notes - |
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info Use at an assay dependent concentration. | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info - | Notes - |
Not recommendedNot recommended
| Species | Dilution info | Notes |
|---|---|---|
Species Recombinant full length protein | Dilution info - | Notes - |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Recombinant full length protein | Dilution info 1/500.00000 - 1/2000.00000 | Notes - |
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info - | Notes - |
Species Human | Dilution info 1/500.00000 - 1/2000.00000 | Notes - |
Not recommendedNot recommended
| Species | Dilution info | Notes |
|---|---|---|
Species Synthetic peptide | Dilution info - | Notes - |
ICC/IF
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info 1/200.00000 - 1/1000.00000 | Notes - |
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/200.00000 - 1/1000.00000 | Notes - |
Not recommendedNot recommended
| Species | Dilution info | Notes |
|---|---|---|
Species Synthetic peptide, Recombinant full length protein | Dilution info - | Notes - |
Associated Products
Select an associated product type
5 products for Alternative Product
Target data
Function
Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix. Has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.
Alternative names
Fibrinogen gamma chain, FGG, PRO2061
Recommended products
Mouse Monoclonal Fibrinogen gamma chain antibody. Suitable for ELISA, WB, ICC/IF and reacts with Synthetic peptide, Mouse, Recombinant full length protein, Human samples. Cited in 9 publications. Immunogen corresponding to Recombinant Fragment Protein within Human FGG aa 200-450.
Key facts
- Isotype
IgG2b
- Host species
Mouse
- Storage buffer
Preservative: 0.05% Sodium azide
Constituents: PBS- Form
Liquid
- Clonality
Monoclonal
- Immunogen
- Recombinant Fragment Protein within Human FGG aa 200-450. The exact immunogen used to generate this antibody is proprietary information. Database link P02679
- Clone number
5A6
- Purification technique
Affinity purification Protein G
- Concentration
- Purification notes
Purified from tissue culture supernatant.
Storage
- Shipped at conditions
Blue Ice
- Appropriate short-term storage duration
1-2 weeks
- Appropriate short-term storage conditions
+4°C
- Appropriate long-term storage conditions
-20°C
Notes
This product was changed from ascites to supernatant. Lot no's high than GR240839-12 are from Tissue Culture Supernatant
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Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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3 product images
![Western blot - Anti-Fibrinogen gamma chain antibody [5A6] (ab119948), expandable thumbnail](https://content.abcam.com/products/images/fibrinogen-gamma-chain-antibody-5a6-ab119948--western-blot-img63371.jpg "Western blot - Anti-Fibrinogen gamma chain antibody [5A6] (ab119948)")
Western blot - Anti-Fibrinogen gamma chain antibody [5A6] (ab119948)
All lanes: Western blot - Anti-Fibrinogen gamma chain antibody [5A6] (ab119948) at 1/500 dilution
All lanes: Recombinant Fibrinogen gamma chain protein
Predicted band size: 52 kDa
![Immunocytochemistry/ Immunofluorescence - Anti-Fibrinogen gamma chain antibody [5A6] (ab119948), expandable thumbnail](https://content.abcam.com/products/images/fibrinogen-gamma-chain-antibody-5a6-ab119948--immunocytochemistry-immunofluorescence-img93444.jpg "Immunocytochemistry/ Immunofluorescence - Anti-Fibrinogen gamma chain antibody [5A6] (ab119948)")
Immunocytochemistry/ Immunofluorescence - Anti-Fibrinogen gamma chain antibody [5A6] (ab119948)
Immunofluorescence analysis of NIH3T3 cells using ab119948 at a dilution of 1/200 (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.
![ELISA - Anti-Fibrinogen gamma chain antibody [5A6] (ab119948), expandable thumbnail](https://content.abcam.com/products/images/fibrinogen-gamma-chain-antibody-5a6-ab119948--elisa-img415654.jpg "ELISA - Anti-Fibrinogen gamma chain antibody [5A6] (ab119948)")
ELISA - Anti-Fibrinogen gamma chain antibody [5A6] (ab119948)
ELISA, using ab119948 at a dilution of 1/10000.
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