JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB194395

Anti-Fibronectin antibody [TV.1]

Be the first to review this product! Submit a review

|

(8 Publications)

Mouse Monoclonal Fibronectin antibody. Suitable for IHC-P and reacts with Human samples. Cited in 8 publications. Immunogen corresponding to Cell preparation containing FN1 protein.

View Alternative Names

FN, FN1, Fibronectin, Cold-insoluble globulin, CIG

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Fibronectin antibody [TV.1] (AB194395)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Fibronectin antibody [TV.1] (AB194395)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human pancreatic adenocarcinoma tissue labelling Fibronectin with ab194395 at 2 μg/mL. Heat mediated antigen retrieval was performed using 10 mM Tris/1 mM EDTA buffer pH 9 for 45 minutes at 95°C followed by cooling at room temperature for 20 minutes. Primary incubation for 30 minutes at room temperature.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

TV.1

Isotype

IgG1

Light chain type

kappa

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Cell preparation containing FN1 protein. The exact immunogen used to generate this antibody is proprietary information.

P02751

Specificity

ab194395 reacts with the cellular as well as plasma form of Fibronectin.

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/1 - 1/2", "IHCP-species-notes": "<p></p>" } } }
style
left-column

Have you thought about this alternative?

AB199056

Anti-Fibronectin antibody [EPR19241-46]

4
2 Reviews
View product

We’re constantly upgrading our range to offer the highest quality products. We have selected this alternative product for your review because it gives improved performance, is easier and more convenient to use, or is available faster.

style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purified from Bioreactor Concentrate
Storage buffer
pH: 7.2 - 7.4 Preservative: 0.05% Sodium azide Constituents: 99% PBS, 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin (PubMed : 3024962, PubMed : 3593230, PubMed : 3900070, PubMed : 7989369). Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape (PubMed : 3024962, PubMed : 3593230, PubMed : 3900070, PubMed : 7989369). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (By similarity). Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). Acts as a ligand for the LILRB4 receptor, inhibiting FCGR1A/CD64-mediated monocyte activation (PubMed : 34089617).. Anastellin. Binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling.. Secreted by contracting muscle, induces liver autophagy, a degradative pathway for nutrient mobilization and damage removal, and systemic insulin sensitization via hepatic ITGA5 : ITGB1 integrin receptor signaling.
See full target information FN1
style
left-column

Publications (8)

Recent publications for all applications. Explore the full list and refine your search

Biomedicines 10: PubMed35203480

2022

Decellularized In Vitro Capillaries for Studies of Metastatic Tendency and Selection of Treatment.

Applications

Unspecified application

Species

Unspecified reactive species

Outi Huttala,Desiree Loreth,Synnöve Staff,Minna Tanner,Harriet Wikman,Timo Ylikomi

Scientific reports 10:9468 PubMed32528073

2020

Detachment of cell sheets from clinically ubiquitous cell culture vessels by ultrasonic vibration.

Applications

Unspecified application

Species

Unspecified reactive species

Chikahiro Imashiro,Makoto Hirano,Takashi Morikura,Yuki Fukuma,Kiyoshi Ohnuma,Yuta Kurashina,Shogo Miyata,Kenjiro Takemura

FASEB journal : official publication of the Federa 34:8625-8640 PubMed32374060

2020

H19/TET1 axis promotes TGF-β signaling linked to endothelial-to-mesenchymal transition.

Applications

Unspecified application

Species

Unspecified reactive species

Tiefeng Cao,Ying Jiang,Da Li,Xiaoli Sun,Yuanyuan Zhang,Lingfeng Qin,George Tellides,Hugh S Taylor,Yingqun Huang

Cell reports 30:1310-1318.e5 PubMed32023451

2020

A Positive Feedback Loop of TET3 and TGF-β1 Promotes Liver Fibrosis.

Applications

Unspecified application

Species

Unspecified reactive species

Yetao Xu,Xiaoli Sun,Ruling Zhang,Tiefeng Cao,Shi-Ying Cai,James L Boyer,Xuchen Zhang,Da Li,Yingqun Huang

Scientific reports 8:11438 PubMed30061663

2018

LRP1 is required for novobiocin-mediated fibronectin turnover.

Applications

Unspecified application

Species

Unspecified reactive species

Natasha Marie-Eraine Boel,Morgan Campbell Hunter,Adrienne Lesley Edkins

Theranostics 7:3326-3337 PubMed28900513

2017

Cancer Cells Elimination Guided by Aptamer-Functionalized Gold-Coated Magnetic Nanoparticles and Controlled with Low Frequency Alternating Magnetic Field.

Applications

Unspecified application

Species

Unspecified reactive species

Irina V Belyanina,Tatiana N Zamay,Galina S Zamay,Sergey S Zamay,Olga S Kolovskaya,Tatiana I Ivanchenko,Valery V Denisenko,Andrey K Kirichenko,Yury E Glazyrin,Irina V Garanzha,Valentina V Grigorieva,Alexandr V Shabanov,Dmitry V Veprintsev,Alexey E Sokolov,Vladimir M Sadovskii,Ana Gargaun,Maxim V Berezovski,Anna S Kichkailo

Molecular medicine reports 15:4247-4252 PubMed28440499

2017

Effects of tanshinone IIA on the regulation of renal proximal tubular fibrosis.

Applications

Unspecified application

Species

Unspecified reactive species

Luoyuan Cao,Baoying Huang,Xianguo Fu,Jing Yang,Yinghua Lin,Feng Lin

Oncotarget 6:36126-38 PubMed26418881

2015

The effective bioengineering method of implantation decellularized renal extracellular matrix scaffolds.

Applications

Unspecified application

Species

Unspecified reactive species

Yong Guan,Shuangde Liu,Chao Sun,Guanghui Cheng,Feng Kong,Yun Luan,Xiaoshuai Xie,Shengtian Zhao,Denglu Zhang,Jue Wang,Kailin Li,Yuqiang Liu
View all publications
style
left-column
style
left-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions
style
left-column
style
right-column

Associated Products

Select an associated product type
Alternative Product
Primary Antibodies

AB198934

Alexa Fluor® 647 Anti-Fibronectin antibody [F1]

primary-antibodies

alexa-fluor-647-fibronectin-antibody-f1-ab198934

0

(0 reviews)

Alternative Product
Primary Antibodies

AB45688

Anti-Fibronectin antibody [F14]

primary-antibodies

fibronectin-antibody-f14-ab45688

5

(5 reviews)

Alternative Product
Primary Antibodies

AB206928

Anti-Fibronectin antibody [F14] - BSA and Azide free

primary-antibodies

fibronectin-antibody-f14-bsa-and-azide-free-ab206928

0

(0 reviews)

Alternative Product
Primary Antibodies

AB207628

HRP Anti-Fibronectin antibody [F14]

primary-antibodies

hrp-fibronectin-antibody-f14-ab207628

0

(0 reviews)

Alternative Product
Primary Antibodies

AB271831

Anti-Fibronectin antibody [F1] - BSA and Azide free

primary-antibodies

fibronectin-antibody-f1-bsa-and-azide-free-ab271831

5

(1 reviews)

Alternative Product
Primary Antibodies

AB198933

Alexa Fluor® 488 Anti-Fibronectin antibody [F1]

primary-antibodies

alexa-fluor-488-fibronectin-antibody-f1-ab198933

0

(1 reviews)

Alternative Product
Primary Antibodies

AB32419

Anti-Fibronectin antibody [F1]

primary-antibodies

fibronectin-antibody-f1-ab32419

5

(7 reviews)

Alternative Product
Primary Antibodies

AB219366

Anti-Fibronectin antibody [F1] - Low endotoxin, Azide free

primary-antibodies

fibronectin-antibody-f1-low-endotoxin-azide-free-ab219366

4

(1 reviews)

style
bg-slate-100

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com