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AB185674

Anti-FIGNL1 antibody

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Rabbit Polyclonal FIGNL1 antibody. Suitable for IHC-P, WB and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human FIGNL1 aa 550 to C-terminus.

View Alternative Names

Fidgetin-like protein 1, FIGNL1

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FIGNL1 antibody (AB185674)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FIGNL1 antibody (AB185674)

Immunohistochemical analysis of paraffin embedded Human kidney tissue labeling FIGNL1 with ab185674 at a 1/200 dilution.

Western blot - Anti-FIGNL1 antibody (AB185674)
  • WB

Supplier Data

Western blot - Anti-FIGNL1 antibody (AB185674)

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Western blot - Anti-FIGNL1 antibody (ab185674)

Lane 2:

Western blot - Anti-FIGNL1 antibody (ab185674) at 0.4 µg/mL

All lanes:

Caco-2 cell lysate

Predicted band size: 74 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human FIGNL1 aa 550 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q6PIW4

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

FIGNL1 (Fidgetin-Like 1) is a member of ATPase family associated with various cellular processes. It bears a molecular mass of approximately 80 kDa. This protein showcases a unique functionality due to its capacity for microtubule severing and remodeling activities. FIGNL1 performs a role in regulating cytoskeletal dynamics which are critical during key cellular events. The expression of FIGNL1 occurs in various tissues with significant expression levels observed in the testes and ovary emphasizing its importance in reproduction.
Biological function summary

FIGNL1 functions in DNA repair and homologous recombination processes. It becomes part of a larger protein complex facilitating its involvement in maintaining genomic integrity. This connection to DNA repair pathways demonstrates its essential role in preventing genotoxic stress. FIGNL1 interacts with proteins such as RAD51 aiding in the accurate repair of DNA double-strand breaks which prevents the accumulation of potentially harmful genetic errors.

Pathways

FIGNL1 integrates into the DNA damage response and repair pathways. It plays an important part in the homologous recombination repair pathway ensuring chromosome stability during cell division. Related proteins like BRCA2 influence FIGNL1’s function within this pathway linking it to mechanisms that preserve cellular genomic stability. The presence of these interactions is significant for a well-functioning cellular response to DNA damage.

FIGNL1's malfunction or inadequacy may contribute to cancer and infertility issues. Research indicates its association with breast cancer in which its pathway partners like BRCA2 become pivotal for understanding tumorigenesis. Additionally disruptions in its regulation can cause infertility highlighting its necessity in reproductive health. Through these pathways FIGNL1 connects to broader clinical concerns suggesting that its proper expression and function are critical for preventing disease.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Involved in DNA double-strand break (DBS) repair via homologous recombination (HR). Recruited at DSB sites independently of BRCA2, RAD51 and RAD51 paralogs in a H2AX-dependent manner. May regulate osteoblast proliferation and differentiation (PubMed : 23754376). May play a role in the control of male meiosis dynamic (By similarity).
See full target information FIGNL1
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Product promise

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