Rabbit Polyclonal Filamin A antibody. Suitable for WB and reacts with Human samples. Cited in 13 publications. Immunogen corresponding to Synthetic Peptide within Human FLNA.
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- Frontiers in cellular neuroscience 16:8598822022Stiffening of Circumferential F-Actin Bands Correlates With Regenerative Failure and May Act as a Biomechanical Brake in the Mammalian Inner Ear.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMark A Rudolf,Anna Andreeva,Christina E Kim,Anthony C-J DeNovio,Antoan N Koshar,Wendy Baker,Alexander X Cartagena-Rivera,Jeffrey T CorwinPubMed 35602553
- International journal of molecular sciences 23:2022Quantitative Proteomics Reveals Molecular Network Driving Stromal Cell Differentiation: Implications for Corneal Wound Healing.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKrishnatej Nishtala,Trailokyanath Panigrahi,Rohit Shetty,Dhanananajay Kumar,Pooja Khamar,Rajiv R Mohan,Vrushali Deshpande,Arkasubhra GhoshPubMed 35269714
- Small (Weinheim an der Bergstrasse, Germany) 16:e20000122020Anti-Atherogenic Effect of Stem Cell Nanovesicles Targeting Disturbed Flow Sites.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJeong-Kee Yoon,Dae-Hyun Kim,Mi-Lan Kang,Hyeon-Ki Jang,Hyun-Ji Park,Jung Bok Lee,Se Won Yi,Hye-Seon Kim,Sewoom Baek,Dan Bi Park,Jin You,Seong-Deok Lee,Yoshitaka Sei,Song Ih Ahn,Young Min Shin,Chang Soo Kim,Sangsu Bae,YongTae Kim,Hak-Joon SungPubMed 32239653
- Integrative biology : quantitative biosciences from nano to macro 8:1049-10582016High content image analysis of focal adhesion-dependent mechanosensitive stem cell differentiation.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAndrew W Holle,Alistair J McIntyre,Jared Kehe,Piyumi Wijesekara,Jennifer L Young,Ludovic G Vincent,Adam J EnglerPubMed 27723854
- Neuroscience letters 629:15-182016Tsc1 haploinsufficiency is sufficient to increase dendritic patterning and Filamin A levels.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLongbo Zhang et. al.PubMed 27345385
- Nature communications 7:116422016Context-dependent switch in chemo/mechanotransduction via multilevel crosstalk among cytoskeleton-regulated MRTF and TAZ and TGFβ-regulated Smad3.Applications:Unspecified applicationReactive species:Unspecified reactive speciesPam Speight et. al.PubMed 27189435
- ACS nano 9:4435-462015Phage-display-guided nanocarrier targeting to atheroprone vasculature.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLucas H Hofmeister et. al.PubMed 25768046
- Human molecular genetics 23:2953-672014Filamin-interacting proteins, Cfm1 and Cfm2, are essential for the formation of cartilaginous skeletal elements.
- Endocrine-related cancer 19:759-772012Enhancing the effectiveness of androgen deprivation in prostate cancer by inducing Filamin A nuclear localization.
- The Journal of biological chemistry 287:43424-372012RSK2 protein suppresses integrin activation and fibronectin matrix assembly and promotes cell migration.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human FLNA. The exact immunogen used to generate this antibody is proprietary information. Database link P21333
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Reactivity data
Select an application| WB | |
|---|---|
| Human | Tested |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/300 - 1/1000 | Notes - |
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Target data
Function
Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863).
Alternative names
FLN, FLN1, FLNA, Filamin-A, FLN-A, Actin-binding protein 280, Alpha-filamin, Endothelial actin-binding protein, Filamin-1, Non-muscle filamin, ABP-280
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Rabbit Polyclonal Filamin A antibody. Suitable for WB and reacts with Human samples. Cited in 13 publications. Immunogen corresponding to Synthetic Peptide within Human FLNA.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human FLNA. The exact immunogen used to generate this antibody is proprietary information. Database link P21333
- Purification technique
- Affinity purification Immunogen
- Concentration
- Purification notes
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Stable for 12 months at -20°C
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
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Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Western blot - Anti-Filamin A antibody (ab51217)
All lanes: Western blot - Anti-Filamin A antibody (ab51217) at 1/300 dilution
Lane 1: Extracts of 293 cells treated with EGF (200ng/ml, 5mins).
Lane 2: Extracts of 293 cells treated with EGF (200ng/ml, 5mins) and peptide.
Predicted band size: 281 kDa
Observed band size: 281 kDa
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