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AB236979

Anti-FILIP1L antibody

2

(1 Review)

|

(1 Publication)

Rabbit Polyclonal FILIP1L antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human FILIP1L aa 1-200.

View Alternative Names

COL4A3BPIP, DOC1, GIP90, FILIP1L, Filamin A-interacting protein 1-like, 130 kDa GPBP-interacting protein, 90 kDa GPBP-interacting protein, Protein down-regulated in ovarian cancer 1, DOC-1

4 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FILIP1L antibody (AB236979)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FILIP1L antibody (AB236979)

Immunohistochemical analysis of paraffin-embedded human colon cancer tissue labelling FILIP1L with ab236979 at 1/100 dilution.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FILIP1L antibody (AB236979)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FILIP1L antibody (AB236979)

Immunohistochemical analysis of paraffin-embedded human colon tissue labelling FILIP1L with ab236979 at 1/100 dilution.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FILIP1L antibody (AB236979)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FILIP1L antibody (AB236979)

Paraffin-embedded human adrenal gland tissue stained for FILIP1L using ab236979 at 1/100 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FILIP1L antibody (AB236979)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FILIP1L antibody (AB236979)

Paraffin-embedded human colon cancer tissue stained for FILIP1L using ab236979 at 1/100 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human FILIP1L aa 1-200. The exact immunogen used to generate this antibody is proprietary information.

Q4L180

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%.
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

FILIP1L also known as FILIP-1-like protein is a protein with a mass of approximately 136 kDa. Mechanically FILIP1L interacts with the actin cytoskeleton affecting cell shape and motility. It modulates cell adhesion by interacting directly with filamin A a cytoskeletal protein. FILIP1L expression occurs in various tissues including the brain heart and liver. Its presence influences cellular architecture through actin binding.
Biological function summary

FILIP1L regulates cell migration and growth. It serves as an important mediator of cellular signaling that influences cytoskeletal dynamics. Although not a part of a multi-protein complex FILIP1L's role extends to the regulation of cell division and apoptosis. It modulates responses to extracellular signals contributing to processes such as cell proliferation and differentiation. Researchers focus on FILIP1L for its dual role in promoting cellular stability and flexibility.

Pathways

FILIP1L plays critical roles in the Wnt and TGF-beta signaling pathways. It works alongside proteins like beta-catenin and SMAD2/3 to influence gene transcription related to cell cycle control and apoptosis. FILIP1L's interaction with these pathways supports its role in maintaining proper cellular communication. The pathways regulate development differentiation and homeostasis reflecting the importance of FILIP1L in broader cellular functions.

FILIP1L associates with cancer and neurological disorders. Cancer studies indicate that FILIP1L expression levels affect tumor progression linked with altered cell migration and invasion. In neurological disorders its role in the brain suggests potential involvement in conditions like neurodegenerative diseases. FILIP1L interacts with proteins such as filamin A and SMAD proteins emphasizing its involvement in both tumor biology and neural health. Understanding FILIP1L better offers insights into therapeutic strategies.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Acts as a regulator of the antiangiogenic activity on endothelial cells. When overexpressed in endothelial cells, leads to inhibition of cell proliferation and migration and an increase in apoptosis. Inhibits melanoma growth When expressed in tumor-associated vasculature.
See full target information FILIP1L
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Aging 11:10203-10219 PubMed31740625

2019

Mitochondrial fission regulator 2 (MTFR2) promotes growth, migration, invasion and tumour progression in breast cancer cells.

Applications

Unspecified application

Species

Unspecified reactive species

Guanming Lu,Yuanhui Lai,Tiantian Wang,Weihao Lin,Jinlan Lu,Yanfei Ma,Yongcheng Chen,Haiqing Ma,Ruilei Liu,Jie Li
View all publications
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Product promise

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