Anti-C1q FITC conjugated antibody (ab4223) rabbit polyclonal antibody that is used to detect C1q in Flow Cytometry, IHC-P. Suitable for Human samples.
- Trusted since 2003
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- Proceedings of the National Academy of Sciences of the United States of America 120:e22175901202023Subclass-switched anti-spike IgG3 oligoclonal cocktails strongly enhance Fc-mediated opsonization.Applications:Unspecified applicationReactive species:Unspecified reactive speciesArman Izadi,Arsema Hailu,Magdalena Godzwon,Sebastian Wrighton,Berit Olofsson,Tobias Schmidt,Anna Söderlund-Strand,Elizabeth Elder,Sofia Appelberg,Maria Valsjö,Olivia Larsson,Vidar Wendel-Hansen,Mats Ohlin,Wael Bahnan,Pontus NordenfeltPubMed 37011197
- Cellular and molecular gastroenterology and hepatology 13:289-3072021C-Reactive Protein Protects Against Acetaminophen-Induced Liver Injury by Preventing Complement Overactivation.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHai-Yun Li,Zhao-Ming Tang,Zhe Wang,Jian-Min Lv,Xiao-Ling Liu,Yu-Lin Liang,Bin Cheng,Ning Gao,Shang-Rong Ji,Yi WuPubMed 34536564
- Infection and immunity 89:e00412212021Anti-LPS IgA and IgG Can Inhibit Serum Killing of Pseudomonas aeruginosa in Patients with Cystic Fibrosis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAmy Pham,Emma L Ledger,Carrie F Coggon,Ian R Henderson,David W Reid,Scott C Bell,Daniel J Smith,Timothy J WellsPubMed 34460286
- Cell host & microbe 29:165-178.e82020The immune landscape in tuberculosis reveals populations linked to disease and latency.Applications:Unspecified applicationReactive species:Unspecified reactive speciesEkaterina Esaulova,Shibali Das,Dhiraj Kumar Singh,Jose Alberto Choreño-Parra,Amanda Swain,Laura Arthur,Javier Rangel-Moreno,Mushtaq Ahmed,Bindu Singh,Ananya Gupta,Luis Alejandro Fernández-López,Maria de la Luz Garcia-Hernandez,Allison Bucsan,Chivonne Moodley,Smriti Mehra,Ethel García-Latorre,Joaquin Zuniga,Jeffrey Atkinson,Deepak Kaushal,Maxim N Artyomov,Shabaana A KhaderPubMed 33340449
- mAbs 11:826-8362019Effects of terminal galactose residues in mannose α1-6 arm of Fc-glycan on the effector functions of therapeutic monoclonal antibodies.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMichihiko Aoyama et. al.PubMed 30990348
- Scientific reports 8:179172018Extracellular vesicles are associated with the systemic inflammation of patients with seropositive rheumatoid arthritis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesCatalina Burbano et. al.PubMed 30559453
- Frontiers in immunology 9:3222018Potential Involvement of Platelet-Derived Microparticles and Microparticles Forming Immune Complexes during Monocyte Activation in Patients with Systemic Lupus Erythematosus.Applications:Unspecified applicationReactive species:Unspecified reactive speciesCatalina Burbano et. al.PubMed 29545790
- Journal of inflammation (London, England) 12:512015The role of C1q in recognition of apoptotic epithelial cells and inflammatory cytokine production by phagocytes during Helicobacter pylori infection.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSarah Fox et. al.PubMed 26357509
- The Journal of biological chemistry 287:13829-392012Complement-dependent cytotoxicity in neuromyelitis optica requires aquaporin-4 protein assembly in orthogonal arrays.Applications:ICC/IFReactive species:Unspecified reactive speciesPuay-Wah Phuan,Julien Ratelade,Andrea Rossi,Lukmanee Tradtrantip,A S VerkmanPubMed 22393049
- Proceedings of the National Academy of Sciences of 108:12485-902011Evasion of immunity to Plasmodium falciparum malaria by IgM masking of protective IgG epitopes in infected erythrocyte surface-exposed PfEMP1.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Conjugation
- FITC
- Excitation/Emission
- Ex: 495nm, Em: 519nm
- Storage buffer
Preservative: 0.05% Sodium azide
Constituents: 1% BSA- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Native Full Length Protein corresponding to Human C1QA. Database link P02745
Reactivity data
Select an application| ICC | Flow Cyt | IHC-P | |
|---|---|---|---|
| Human | Tested | Expected | Expected |
ICC
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info - | Notes - |
Flow Cyt
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info - | Notes ab37406 - Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody. |
IHC-P
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info Use at an assay dependent concentration. | Notes - |
Associated Products
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Target data
Function
C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.
Alternative names
Complement C1q subcomponent subunit A, C1QA
Recommended products
Anti-C1q FITC conjugated antibody (ab4223) rabbit polyclonal antibody that is used to detect C1q in Flow Cytometry, IHC-P. Suitable for Human samples.
- Trusted since 2003
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Conjugation
- FITC
- Excitation/Emission
- Ex: 495nm, Em: 519nm
- Storage buffer
Preservative: 0.05% Sodium azide
Constituents: 1% BSA- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Native Full Length Protein corresponding to Human C1QA. Database link P02745
- Purity
- IgG fraction
- Concentration
- Purification notes
Traces of contaminating antibodies have been removed by solid phase absorption with human plasma proteins.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- +4°C
Notes
FITC Anti-C1q antibody (ab4223) is a rabbit polyclonal antibody and is validated for use in Flow Cytometry (Flow Cyt), Immunohistochemistry (IHC-P) in Human samples.
Trusted by the scientific community
Anti-C1q FITC (ab4223) was first used in a scientific publication in 2003 and has been cited over 10 times in peer-reviewed journals.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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In the unlikely event of one of our products not working as expected, you are covered by our product promise.
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2 product images
Immunocytochemistry - FITC Anti-C1q antibody (ab4223)
C1q isolated from the NHS. This antibody reacts with the Human C1q complement. Traces of contaminating antibodies have been removed by solid phase absorption with human plasma proteins. This antibody is well suited for tissue section staining but may also be used for other applications.
Image from Phuan PW et al., J Biol Chem. 2012 Apr 20;287(17):13829-39. Epub 2012 Mar 5. Fig 7.; doi: 10.1074/jbc.M112.344325; April 20, 2012, The Journal of Biological Chemistry, 287, 13829-13839.Immunocytochemistry - FITC Anti-C1q antibody (ab4223)
ab4223, staining C1q in CHO-K1 cells transfected with M1-AQP4 or M23-AQP4 by Immunocytochemistry/ Immunofluorescence.
Cells were incubated at room temperature with recombinant monoclonal NMO antibody and 120 µg/ml human C1q protein (ab96363). Cells were washed with PBS, fixed in paraformaldehyde and permeabilized with 0.1% Triton X-100. Cells were blocked with 1% BSA for 30 min and incubated for 60 min with primary antibody against C1q (ab4223) at 1/200 dilution.
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