Goat Polyclonal C3 antibody - conjugated to FITC. Suitable for ICC, ELISA, ICC/IF, IHC-Fr and reacts with Rat samples. Immunogen corresponding to Native Full Length Protein corresponding to Rat C3.
pH: 7.2
Constituents: 100% PBS
| ICC | ELISA | ICC/IF | IHC-Fr | |
|---|---|---|---|---|
| Rat | Expected | Expected | Expected | Expected |
| Species | Dilution info | Notes |
|---|---|---|
Species Rat | Dilution info Use at an assay dependent concentration. | Notes - |
| Species | Dilution info | Notes |
|---|---|---|
Species Rat | Dilution info Use at an assay dependent concentration. | Notes - |
| Species | Dilution info | Notes |
|---|---|---|
Species Rat | Dilution info Use at an assay dependent concentration. | Notes - |
| Species | Dilution info | Notes |
|---|---|---|
Species Rat | Dilution info Use at an assay dependent concentration. | Notes - |
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C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. In chronic inflammation, acts as a chemoattractant for neutrophils (PubMed:8352775). C3-beta-c. Acts as a chemoattractant for neutrophils in chronic inflammation. Acylation stimulating protein. Adipogenic hormone that stimulates triglyceride (TG) synthesis and glucose transport in adipocytes, regulating fat storage and playing a role in postprandial TG clearance. Appears to stimulate TG synthesis via activation of the PLC, MAPK and AKT signaling pathways. Ligand for C5AR2. Promotes the phosphorylation, ARRB2-mediated internalization and recycling of C5AR2 (By similarity).
Complement C3, C3
Goat Polyclonal C3 antibody - conjugated to FITC. Suitable for ICC, ELISA, ICC/IF, IHC-Fr and reacts with Rat samples. Immunogen corresponding to Native Full Length Protein corresponding to Rat C3.
pH: 7.2
Constituents: 100% PBS
Fluorescein isothiocyanate-conjugated IgG fraction of polyclonal Goat antiSerum to C3c fragment of Rat complement factor C3.
The antiSerum does not cross-react with any other component of Rat plasma. Inter-species cross-reactivity is a normal feature of antibodies to plasma proteins since they frequently share antigenic determinants. Cross-reactivity of this antiSerum has not been tested in detail
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The C3c fragment is part of the complement system which plays an important role in the innate immune system. C3c also known as complement component 3c forms when C3 undergoes cleavage. The molecular mass of C3c ranges from approximately 135 to 186 kDa depending on the level of cleavage. It presents primarily in plasma and serum being part of the larger C3 molecule which is produced by the liver. Within tissues C3c can also appear in inflammatory sites where complement activation occurs.
C3c functions as a by-product of complement activation and is associated with immune defense processes. It does not independently participate in the formation of the complement complex but results from the breakdown of C3 into C3b and other fragments. This fragment may play roles in modulating immune responses through its interaction with complement receptors. The presence of C3c marks the location and intensity of complement activation in tissue or circulation indirectly indicating the body's response to pathogens or damaged cells.
The C3c fragment serves as an indirect marker within the complement cascade particularly signaling the involvement of the classical and alternative complement pathways. The generation of C3c follows the activation of these pathways highlighting the initial activation of C3 into active fragments such as C3b. Proteins related to these pathways include factors H and I which regulate C3b breakdown ensuring controlled progression of this immune response.
C3c levels offer insights into pathological conditions like systemic lupus erythematosus (SLE) and glomerulonephritis. Elevated levels of C3c in serum may indicate excessive complement activation and consumption often observed in these diseases. The association of C3c with disease is often mediated through its precursor C3 with abnormal C3 activation linked to tissue damage in autoimmune conditions. Proteins like C4 and complement receptor (CR1) may also connect to these disorders as they interact in pathways leading to inflammatory responses characterized by complement activity.
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This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
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