AB18278

FITC Anti-CD105 antibody [MEM-226]

Name: FITC Anti-CD105 antibody [MEM-226] (ab18278) | Abcam
Brand: Abcam Limited
SKU: AB18278
Price: 95 USD
Availability: InStock

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(11 Publications)

Mouse Monoclonal CD105 antibody - conjugated to FITC. Suitable for Flow Cyt and reacts with Human samples. Cited in 11 publications.

View Alternative Names

CD105, END, ENG, Endoglin

Unconjugated

Anti-CD105 antibody [MEM-226]
660 APC

APC Anti-CD105 antibody [MEM-226]
778 PE/Cy7®

PE/Cy7® Anti-CD105 antibody [MEM-226]

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

MEM-226

Isotype

IgG2a

Conjugation

FITC

Excitation/Emission

Ex: 495nm, Em: 519nm

Carrier free

Reacts with

Human

Applications

Flow Cyt

applications

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "guaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p>20 ul for 100 ul sample is recommended. <a href='/en-us/products/primary-antibodies/fitc-mouse-igg2a-x5563-isotype-control-ab91362'>ab91362</a> - Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody.</p>" } } }

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Product details

The purified antibody is conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC and adjusted for direct use.

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Properties and storage information

Form

Liquid

Purification technique

Size-exclusion chromatography

Purification notes

Purified by size-exclusion chromatography.

Storage buffer

pH: 7.4 Preservative: 0.097% Sodium azide Constituents: BSA, PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

+4°C

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CD105 also known as endoglin or the CD105 marker is a transmembrane glycoprotein with a molecular weight of approximately 180 kDa. It is a component of the TGF-beta receptor complex and exists in endothelial cells where it is abundantly expressed. Expression of CD105 is higher in proliferating cells particularly in the vasculature. You can also find it in tissues involved in the formation and remodeling of blood vessels such as during angiogenesis.

Biological function summary

Endoglin functions in the regulation of angiogenesis and vascular remodeling. It plays a significant role in mediating cellular responses to TGF-beta signaling influencing endothelial cell proliferation and migration. While not part of a larger structural complex endoglin interacts with receptors and signaling molecules important for vascular development and repair processes. This involvement aids in maintaining endothelial integrity and function under various physiological conditions.

Pathways

CD105 participates in the TGF-beta signaling and angiogenesis pathways. In these pathways it acts in conjunction with other proteins like TGF-beta receptors which play roles in cell differentiation proliferation and apoptosis. The interaction between CD105 and TGF-beta signaling regulates numerous cellular mechanisms impacting angiogenesis and cellular responses to environmental changes.

CD105 has links to hereditary hemorrhagic telangiectasia (HHT) and certain cancers. In HHT mutations in the endoglin gene alter vascular structure leading to the formation of abnormal blood vessels. Oncologically overexpression of CD105 is present in tumor angiogenesis aiding in the progression of certain cancers. Other proteins like VEGF and TGF-beta closely interact with endoglin influencing disease progression and presenting potential targets for therapeutic intervention.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
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Target data

Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis (PubMed : 21737454, PubMed : 23300529). Required for normal structure and integrity of adult vasculature (PubMed : 7894484). Regulates the migration of vascular endothelial cells (PubMed : 17540773). Required for normal extraembryonic angiogenesis and for embryonic heart development (By similarity). May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (By similarity). May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors (PubMed : 1692830). Acts as a TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors (PubMed : 21737454, PubMed : 22347366, PubMed : 23300529, PubMed : 8370410). Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGFB1 signaling through SMAD3 (PubMed : 21737454, PubMed : 22347366, PubMed : 23300529).

See full target information ENG

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Publications (11)

Recent publications for all applications. Explore the full list and refine your search

Tissue engineering and regenerative medicine 21:609-624 PubMed38568409

2024

Effects of Mesenchymal Stem Cells-Derived Extracellular Vesicles on Inhibition of Hepatic Fibrosis by Delivering miR-200a.

Applications

Unspecified application

Species

Unspecified reactive species

Ai-Lei Xu,Long Han,Jun Yan,Dan Liu,Wei Wang

Tissue engineering and regenerative medicine 19:1321-1336 PubMed36074328

2022

The Combination of Platelet Rich Plasma Gel, Human Umbilical Mesenchymal Stem Cells and Nanohydroxyapatite/polyamide 66 Promotes Angiogenesis and Bone Regeneration in Large Bone Defect.

Applications

Unspecified application

Species

Unspecified reactive species

Wei Liu,Yong Huang,Daqian Liu,Teng Zeng,Jingzhe Wang,Ang Li,Dawei Wang,Xiaoyu Wang

Global spine journal 13:2396-2408 PubMed35400210

2022

Mechanism of the Mitogen-Activated Protein Kinases/Mammalian Target of Rapamycin Pathway in the Process of Cartilage Endplate Stem Cell Degeneration Induced by Tension Load.

Applications

Unspecified application

Species

Unspecified reactive species

Yu Zhang,Chen Liu,Yu Li,Hongguang Xu

Bioengineered 12:12891-12904 PubMed34784837

2021

MiR-455-5p upregulation in umbilical cord mesenchymal stem cells attenuates endometrial injury and promotes repair of damaged endometrium via Janus kinase/signal transducer and activator of transcription 3 signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Dongyan Sun,Zhihe Jiang,Yanling Chen,Di Shang,Pan Miao,Jian Gao

Journal of biochemical and molecular toxicology 34:e22436 PubMed31953908

2020

SENP1/HIF-1α axis works in angiogenesis of human dental pulp stem cells.

Applications

Unspecified application

Species

Unspecified reactive species

Jie Zhou,Cong Sun

Bio-protocol 8:e2693 PubMed34179242

2018

Human Endometrial Stem Cell Isolation from Endometrium and Menstrual Blood.

Applications

Unspecified application

Species

Unspecified reactive species

Shima Tavakol,Fereshteh Azedi,Elham Hoveizi,Jafar Ai,Mohammad Taghi Joghataei

Cell transplantation 26:867-878 PubMed28105983

2017

Effect of Bone Marrow Aspirate Concentrate-Platelet-Rich Plasma on Tendon-Derived Stem Cells and Rotator Cuff Tendon Tear.

Applications

Unspecified application

Species

Unspecified reactive species

Sun Jeong Kim,Da Hyun Song,Jong Wook Park,Silvia Park,Sang Jun Kim

BMC cell biology 12:44 PubMed21992089

2011

Age-related changes in rat bone-marrow mesenchymal stem cell plasticity.

Applications

Flow Cyt

Species

Rat

Faizal Z Asumda,P Bryant Chase

Stem cells and development 20:925-31 PubMed20735179

2010

The effects of 17-β estradiol on enhancing proliferation of human bone marrow mesenchymal stromal cells in vitro.

Applications

Flow Cyt

Species

Human

Liu Hong,Guoquan Zhang,Habiba Sultana,Yang Yu,Zhen Wei

Journal of biomedical materials research. Part A 94:978-87 PubMed20730935

2010

FGF-2 abolishes the chondrogenic effect of combined BMP-6 and TGF-beta in human adipose derived stem cells.

Applications

Flow Cyt

Species

Human

Florian Hildner,Anja Peterbauer,Susanne Wolbank,Sylvia Nürnberger,Stefan Marlovits,Heinz Redl,Martijn van Griensven,Christian Gabriel

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

FITC Anti-CD105 antibody [MEM-226]

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Key facts

Host species

Clonality

Clone number

Isotype

Conjugation

Excitation/Emission

Carrier free

Reacts with

Applications

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Reactivity data

Product details

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (11)

Product promise