Mouse Monoclonal CD105 antibody - conjugated to FITC. Suitable for Flow Cyt and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Human ENG.
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![Flow Cytometry - FITC Anti-CD105 antibody [SN6] (AB11415), expandable thumbnail](https://content.abcam.com/products/images/fitc-cd105-antibody-sn6-ab11415--flow-cytometry-img47529.jpg/_jcr_content/renditions/webp-475.webp "Flow Cytometry - FITC Anti-CD105 antibody [SN6] (AB11415)")
Publications
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- Animals : an open access journal from MDPI 13:2022Isolation and Identification of Bone Marrow Mesenchymal Stem Cells from Forest Musk Deer.Applications:Unspecified applicationReactive species:Unspecified reactive speciesWeiqiang Luo,Yangyang Geng,Mengxi Gao,Mengting Cao,Junjian Wang,Jing Yang,Chenxuan Sun,Xingrong YanPubMed 36611625
- BMC veterinary research 17:2722021Isolation and identification of exosomes from feline plasma, urine and adipose-derived mesenchymal stem cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDongsheng Li,Huina Luo,Huimin Ruan,Zhisheng Chen,Shengfeng Chen,Bingyun Wang,Yong XiePubMed 34384449
- Journal of chemical neuroanatomy 114:1019612021Implantation of human olfactory ecto-mesenchymal stem cells restores locomotion in a rat model of Parkinson's disease.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMohammad Farhadi,Mahdi Eskandarian Boroujeni,Seyed Kamran Kamrava,Zohreh Bagher,Ava Modirzadeh Tehrani,Fakhroddin Aghajanpour,Samira Ezi,Reza Soltani,Aysan Khatmi,Rafieh AlizadehPubMed 33933574
- Autophagy 17:3140-31592021BNIP3L-mediated mitophagy is required for mitochondrial remodeling during the differentiation of optic nerve oligodendrocytes.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMeysam Yazdankhah,Sayan Ghosh,Peng Shang,Nadezda Stepicheva,Stacey Hose,Haitao Liu,Xitiz Chamling,Shenghe Tian,Mara L G Sullivan,Michael Joseph Calderon,Christopher S Fitting,Joseph Weiss,Ashwath Jayagopal,James T Handa,José-Alain Sahel,J Samuel Zigler,Paul R Kinchington,Donald J Zack,Debasish SinhaPubMed 33404293
- Journal of materials science. Materials in medicin 29:882018Hyaluronic acid hydrogels incorporating platelet lysate enhance human pulp cell proliferation and differentiation.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLeopoldina D F Almeida et. al.PubMed 29904797
- PloS one 12:e01829712017Experimental study of ASCs combined with POC-PLA patch for the reconstruction of full-thickness chest wall defects.
Key facts
- Isotype
- IgG1
- Host species
- Mouse
- Conjugation
- FITC
- Excitation/Emission
- Ex: 495nm, Em: 519nm
- Storage buffer
pH: 7.4
Preservative: 0.09% Sodium azide
Constituents: PBS- Form
- Liquid
- Clonality
- Monoclonal
Immunogen
- Synthetic Peptide within Human ENG. The exact immunogen used to generate this antibody is proprietary information. Database link P17813
Reactivity data
Select an application| Flow Cyt | IHC-P | |
|---|---|---|
| Human | Tested | Not recommended |
Flow Cyt
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info - | Notes Use neat. Use 10ul of the suggested working dilution to label 10E6 cells in 100ul. ab91356 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. |
IHC-P
Not recommendedNot recommended
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info - | Notes - |
Associated Products
Select an associated product type
1 product for Alternative Version
6 products for Alternative Product
Target data
Function
Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis (PubMed:21737454, PubMed:23300529). Required for normal structure and integrity of adult vasculature (PubMed:7894484). Regulates the migration of vascular endothelial cells (PubMed:17540773). Required for normal extraembryonic angiogenesis and for embryonic heart development (By similarity). May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (By similarity). May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors (PubMed:1692830). Acts as a TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors (PubMed:21737454, PubMed:22347366, PubMed:23300529, PubMed:8370410). Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGFB1 signaling through SMAD3 (PubMed:21737454, PubMed:22347366, PubMed:23300529).
Alternative names
CD105, END, ENG, Endoglin
Recommended products
Mouse Monoclonal CD105 antibody - conjugated to FITC. Suitable for Flow Cyt and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Human ENG.
Key facts
- Isotype
- IgG1
- Host species
- Mouse
- Conjugation
- FITC
- Excitation/Emission
- Ex: 495nm, Em: 519nm
- Storage buffer
pH: 7.4
Preservative: 0.09% Sodium azide
Constituents: PBS- Form
- Liquid
- Clonality
- Monoclonal
- Immunogen
- Synthetic Peptide within Human ENG. The exact immunogen used to generate this antibody is proprietary information. Database link P17813
- Clone number
- SN6
- Purification technique
- Affinity purification Protein G
- Specificity
ab11415 recognises the human CD105 cell surface antigen. CD105 is expressed by endothelial cells, activated monocytes and some leukaemia cells.
- Concentration
- Purification notes
Purified IgG prepared by affinity chromatography from tissue culture supernatant.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- +4°C
Notes
This product should be stored undiluted.
Storage in frost free freezers is not recommended.
Should this product contain a precipitate we recommend microcentrifugation before use.
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Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
CD105 also known as endoglin or the CD105 marker is a transmembrane glycoprotein with a molecular weight of approximately 180 kDa. It is a component of the TGF-beta receptor complex and exists in endothelial cells where it is abundantly expressed. Expression of CD105 is higher in proliferating cells particularly in the vasculature. You can also find it in tissues involved in the formation and remodeling of blood vessels such as during angiogenesis.
- Biological function summary
Endoglin functions in the regulation of angiogenesis and vascular remodeling. It plays a significant role in mediating cellular responses to TGF-beta signaling influencing endothelial cell proliferation and migration. While not part of a larger structural complex endoglin interacts with receptors and signaling molecules important for vascular development and repair processes. This involvement aids in maintaining endothelial integrity and function under various physiological conditions.
- Pathways
CD105 participates in the TGF-beta signaling and angiogenesis pathways. In these pathways it acts in conjunction with other proteins like TGF-beta receptors which play roles in cell differentiation proliferation and apoptosis. The interaction between CD105 and TGF-beta signaling regulates numerous cellular mechanisms impacting angiogenesis and cellular responses to environmental changes.
- Associated diseases and disorders
CD105 has links to hereditary hemorrhagic telangiectasia (HHT) and certain cancers. In HHT mutations in the endoglin gene alter vascular structure leading to the formation of abnormal blood vessels. Oncologically overexpression of CD105 is present in tumor angiogenesis aiding in the progression of certain cancers. Other proteins like VEGF and TGF-beta closely interact with endoglin influencing disease progression and presenting potential targets for therapeutic intervention.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
![Flow Cytometry - FITC Anti-CD105 antibody [SN6] (ab11415), expandable thumbnail](https://content.abcam.com/products/images/fitc-cd105-antibody-sn6-ab11415--flow-cytometry-img47529.jpg "Flow Cytometry - FITC Anti-CD105 antibody [SN6] (ab11415)")
Flow Cytometry - FITC Anti-CD105 antibody [SN6] (ab11415)
ab11415 staining CD105 in human KG1 cells by Flow Cytometry analysis.
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