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AB11415

FITC Anti-CD105 antibody [SN6]

4

(1 Review)

|

(11 Publications)

Mouse Monoclonal CD105 antibody - conjugated to FITC. Suitable for Flow Cyt and reacts with Human samples. Cited in 11 publications. Immunogen corresponding to Synthetic Peptide within Human ENG.

View Alternative Names

CD105, END, ENG, Endoglin

1 Images
Flow Cytometry - FITC Anti-CD105 antibody [SN6] (AB11415)
  • Flow Cyt

Unknown

Flow Cytometry - FITC Anti-CD105 antibody [SN6] (AB11415)

ab11415 staining CD105 in human KG1 cells by Flow Cytometry analysis.

  • Unconjugated

    Anti-CD105 antibody [SN6]

  • 660 APC

    APC Anti-CD105 antibody [SN6]

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

SN6

Isotype

IgG1

Conjugation

FITC

Excitation/Emission

Ex: 495nm, Em: 519nm

Carrier free

No

Reacts with

Human

Applications

Flow Cyt

applications

Immunogen

Synthetic Peptide within Human ENG. The exact immunogen used to generate this antibody is proprietary information.

P17813

Specificity

ab11415 recognises the human CD105 cell surface antigen. CD105 is expressed by endothelial cells, activated monocytes and some leukaemia cells.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p>Use neat. Use 10µl of the suggested working dilution to label 10<sup>6</sup> cells in 100µl.</p><p><a href='/en-us/products/primary-antibodies/fitc-mouse-igg1-b11-6-isotype-control-ab91356'>ab91356</a> - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.</p>", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" } } }
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Product details

This product should be stored undiluted. Storage in frost free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purified IgG prepared by affinity chromatography from tissue culture supernatant.
Storage buffer
pH: 7.4 Preservative: 0.09% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CD105 also known as endoglin or the CD105 marker is a transmembrane glycoprotein with a molecular weight of approximately 180 kDa. It is a component of the TGF-beta receptor complex and exists in endothelial cells where it is abundantly expressed. Expression of CD105 is higher in proliferating cells particularly in the vasculature. You can also find it in tissues involved in the formation and remodeling of blood vessels such as during angiogenesis.
Biological function summary

Endoglin functions in the regulation of angiogenesis and vascular remodeling. It plays a significant role in mediating cellular responses to TGF-beta signaling influencing endothelial cell proliferation and migration. While not part of a larger structural complex endoglin interacts with receptors and signaling molecules important for vascular development and repair processes. This involvement aids in maintaining endothelial integrity and function under various physiological conditions.

Pathways

CD105 participates in the TGF-beta signaling and angiogenesis pathways. In these pathways it acts in conjunction with other proteins like TGF-beta receptors which play roles in cell differentiation proliferation and apoptosis. The interaction between CD105 and TGF-beta signaling regulates numerous cellular mechanisms impacting angiogenesis and cellular responses to environmental changes.

CD105 has links to hereditary hemorrhagic telangiectasia (HHT) and certain cancers. In HHT mutations in the endoglin gene alter vascular structure leading to the formation of abnormal blood vessels. Oncologically overexpression of CD105 is present in tumor angiogenesis aiding in the progression of certain cancers. Other proteins like VEGF and TGF-beta closely interact with endoglin influencing disease progression and presenting potential targets for therapeutic intervention.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis (PubMed : 21737454, PubMed : 23300529). Required for normal structure and integrity of adult vasculature (PubMed : 7894484). Regulates the migration of vascular endothelial cells (PubMed : 17540773). Required for normal extraembryonic angiogenesis and for embryonic heart development (By similarity). May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (By similarity). May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors (PubMed : 1692830). Acts as a TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors (PubMed : 21737454, PubMed : 22347366, PubMed : 23300529, PubMed : 8370410). Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGFB1 signaling through SMAD3 (PubMed : 21737454, PubMed : 22347366, PubMed : 23300529).
See full target information ENG
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Publications (11)

Recent publications for all applications. Explore the full list and refine your search

iScience 28:112832 PubMed40687841

2025

BMSC exosomes deliver JKAP to restore Th17/Treg balance via AKT/ERK, alleviating rheumatoid arthritis.

Applications

Unspecified application

Species

Unspecified reactive species

Fang-Tian Xu,Yu Ling,Hui-Xian Wei,Lingzhang Meng,Dong Yin,Zhong-Hong Lai,Yu Huang,Xiao Huang,Hai-Ye Li,Qin-Wen Luo,Jian Song,Qiang Tang,Hong-Mian Li

Journal of applied oral science : revista FOB 32:e20230444 PubMed40525809

2025

LncRNA XIST facilitates the odontogenic differentiation of dental pulp stem cells via the FUS/ZBTB16.

Applications

Unspecified application

Species

Unspecified reactive species

Ruiqing Cheng,Honglei Sun,Xiaotong Qiao,Xuefang Chen

Animals : an open access journal from MDPI 13: PubMed36611625

2022

Isolation and Identification of Bone Marrow Mesenchymal Stem Cells from Forest Musk Deer.

Applications

Unspecified application

Species

Unspecified reactive species

Weiqiang Luo,Yangyang Geng,Mengxi Gao,Mengting Cao,Junjian Wang,Jing Yang,Chenxuan Sun,Xingrong Yan

NPJ Regenerative medicine 7:53 PubMed36114225

2022

Chondrogenic primed extracellular vesicles activate miR-455/SOX11/FOXO axis for cartilage regeneration and osteoarthritis treatment.

Applications

Unspecified application

Species

Unspecified reactive species

Ye Sun,Jie Zhao,Qiang Wu,Yuxin Zhang,Yongqing You,Wenbo Jiang,Kerong Dai

BMC veterinary research 17:272 PubMed34384449

2021

Isolation and identification of exosomes from feline plasma, urine and adipose-derived mesenchymal stem cells.

Applications

Unspecified application

Species

Unspecified reactive species

Dongsheng Li,Huina Luo,Huimin Ruan,Zhisheng Chen,Shengfeng Chen,Bingyun Wang,Yong Xie

Journal of nanobiotechnology 19:194 PubMed34193158

2021

Mesenchymal stem cell-derived extracellular vesicles prevent the development of osteoarthritis via the circHIPK3/miR-124-3p/MYH9 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Shenglong Li,Jie Liu,Siyu Liu,Weijie Jiao,Xiaohong Wang

Journal of chemical neuroanatomy 114:101961 PubMed33933574

2021

Implantation of human olfactory ecto-mesenchymal stem cells restores locomotion in a rat model of Parkinson's disease.

Applications

Unspecified application

Species

Unspecified reactive species

Mohammad Farhadi,Mahdi Eskandarian Boroujeni,Seyed Kamran Kamrava,Zohreh Bagher,Ava Modirzadeh Tehrani,Fakhroddin Aghajanpour,Samira Ezi,Reza Soltani,Aysan Khatmi,Rafieh Alizadeh

Molecular biology reports 48:3223-3235 PubMed33929648

2021

The effect of aflibercept and arsenic trioxide on the proliferation, migration and apoptosis of oral squamous cell carcinoma in vitro.

Applications

Unspecified application

Species

Unspecified reactive species

Samira Derakhshan,Pouyan Aminishakib,Fatemeh Pirzadeh,Sedigheh Rahrotaban,Parvaneh Farzaneh,Sahar Tavakoli Shiraji,Meysam Ganjibakhsh,Masoumeh Asadi

Autophagy 17:3140-3159 PubMed33404293

2021

BNIP3L-mediated mitophagy is required for mitochondrial remodeling during the differentiation of optic nerve oligodendrocytes.

Applications

Unspecified application

Species

Unspecified reactive species

Meysam Yazdankhah,Sayan Ghosh,Peng Shang,Nadezda Stepicheva,Stacey Hose,Haitao Liu,Xitiz Chamling,Shenghe Tian,Mara L G Sullivan,Michael Joseph Calderon,Christopher S Fitting,Joseph Weiss,Ashwath Jayagopal,James T Handa,José-Alain Sahel,J Samuel Zigler,Paul R Kinchington,Donald J Zack,Debasish Sinha

Journal of materials science. Materials in medicin 29:88 PubMed29904797

2018

Hyaluronic acid hydrogels incorporating platelet lysate enhance human pulp cell proliferation and differentiation.

Applications

Unspecified application

Species

Unspecified reactive species

Leopoldina D F Almeida,Pedro S Babo,Cristiana R Silva,Márcia T Rodrigues,Josimeri Hebling,Rui L Reis,Manuela E Gomes
View all publications
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