Mouse Monoclonal CD11b antibody - conjugated to FITC. Suitable for Flow Cyt and reacts with Pig samples. Immunogen corresponding to Cell preparation containing CD11b protein.
pH: 7.4
Preservative: 0.09% Sodium azide
Constituents: PBS
| Flow Cyt | |
|---|---|
| Pig | Expected |
| Species | Dilution info | Notes |
|---|---|---|
Species Pig | Dilution info - | Notes Neat - 1/10. Use 10ul of the suggested working dilution to 1x10^6 cells in 100ul. ab91356 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. |
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Antigen CD11b p170, CD11 antigen-like family member B, CD11b/CD18, CD49D, CR 3 alpha chain (CR3A), CR-3 alpha chain, CR3, CR3A, Cell surface glycoprotein MAC-1 subunit alpha, Complement Component Receptor 3 Alpha, Complement component 3 receptor 3 subunit, Complement receptor type 3, Complement receptor type 3, alpha subunit, F730045J24Rik, ITAM_HUMAN, ITGAM, Integrin alpha M chain, Integrin alpha-M, Integrin beta 2 alpha subunit, Integrin subunit alpha M, Leukocyte adhesion receptor MO1, Ly-40, MAC 1, MGC117044, MO1A, Mac-1a, Mac1, alpha subunit, Macrophage antigen alpha polypeptide, Mo1, Mo1, alpha subunit, Neutrophil adherence receptor, Neutrophil adherence receptor alpha M subunit, SLEB6, antigen CD11b (p170), integrin, alpha M (complement component 3 receptor 3 subunit)
Mouse Monoclonal CD11b antibody - conjugated to FITC. Suitable for Flow Cyt and reacts with Pig samples. Immunogen corresponding to Cell preparation containing CD11b protein.
pH: 7.4
Preservative: 0.09% Sodium azide
Constituents: PBS
ab34444 is expressed on granulocytes, monocytes and alveolar macrophages, but not on lymphocytes, eythrocytes or platelets.
ab34444 is reported to block phagocytosis of complement-opsonised zymosan particles by polymononuclear granulocytes and alveolar macrophages.
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CD11b also known as Integrin alpha M is a protein with a molecular weight of approximately 170 kDa. This protein functions mechanically as an important adhesion molecule. It forms a complex with CD18 to become part of leukocyte-specific beta2 integrins specifically the Mac-1 (CR3) receptor. CD11b is largely expressed on the surface of various myeloid cells including monocytes macrophages granulocytes and a subset of natural killer cells. Researchers often utilize anti-CD11b antibodies and other markers such as APC or CD11b IHC to study its expression in different contexts.
CD11b plays a critical role in various immune responses by mediating phagocytosis chemotaxis and cell migration. It is essential for proper leukocyte adherence to endothelial cells and for the engulfment of pathogens or apoptotic cells. CD11b as part of the Mac-1 complex contributes to the immune surveillance and inflammatory processes. This complex interacts with diverse ligands like ICAM-1 fibrinogen and complement component iC3b facilitating an immunological response.
CD11b is instrumental within the integrin signaling pathway and the Leukocyte Transendothelial Migration pathway. Its interaction with ICAM-1 is central to the leukocyte adhesion cascade influencing the movement of immune cells across endothelial barriers. CD11b also associates with proteins such as Src family kinases and PI3K which activate downstream signaling responsible for the reorganization of the cytoskeleton and cell movement during immune responses.
CD11b is linked to inflammatory conditions like rheumatoid arthritis and systemic lupus erythematosus. Aberrant expression or function of CD11b can result in improper immune regulation contributing to the pathogenesis of these diseases. Its interaction with complement receptor iC3b plays a part in inflammation and tissue damage observed in these conditions. Consequently CD11b represents a potential target for therapeutic intervention in diseases where dysregulated immune activity is a feature.
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This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
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