Mouse Monoclonal CD11c antibody - conjugated to FITC. Suitable for Flow Cyt and reacts with Cynomolgus monkey, Human, Dog samples. Cited in 4 publications.
IgG1
Mouse
FITC
Ex: 495nm, Em: 519nm
Preservative: 0.09% Sodium azide
Constituents: 1% BSA
Liquid
Monoclonal
| Flow Cyt | |
|---|---|
| Human | Expected |
| Cynomolgus monkey | Expected |
| Dog | Expected |
| Species | Dilution info | Notes |
|---|---|---|
Species Cynomolgus monkey | Dilution info 1/1.00000 - 1/10.00000 | Notes ab91356 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. Use 10μl of working dilution for 106 cells. |
Species Human | Dilution info 1/1.00000 - 1/10.00000 | Notes ab91356 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. Use 10μl of working dilution for 106 cells. |
Species Dog | Dilution info 1/1.00000 - 1/10.00000 | Notes ab91356 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. Use 10μl of working dilution for 106 cells. |
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Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis.
CD11C, ITGAX, CD11C, Integrin alpha-X, CD11 antigen-like family member C, Leu M5
Mouse Monoclonal CD11c antibody - conjugated to FITC. Suitable for Flow Cyt and reacts with Cynomolgus monkey, Human, Dog samples. Cited in 4 publications.
IgG1
Mouse
FITC
Ex: 495nm, Em: 519nm
Preservative: 0.09% Sodium azide
Constituents: 1% BSA
Liquid
Monoclonal
BU15
Affinity purification Protein G
This antibody recognises the integrin alphax subunit, a 150kD glycoprotein expressed by macrophages, monocytes, granulocytes and NK cells. The antigen is also expressed by hairy cell leukaemia cells. Ligands for CD11c are ICAM 1, iC3b, and fibrinogen. The molecule has a role in mediating adherence of granulocytes and monocytes to endothelium and fibrinogen.
Blue Ice
1-2 weeks
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
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This supplementary information is collated from multiple sources and compiled automatically.
CD11c also known as ITGAX is a subunit of integrin proteins that plays a pivotal role in immune cell function. This protein has a molecular mass of about 150 kDa and is primarily expressed on the surface of dendritic cells monocytes and macrophages. It serves as a marker for these cells commonly utilized in applications like CD11c flow cytometry and CD11c IHC. Researchers often study this target using CD11c antibodies to explore immune system dynamics and cell surface characteristics.
CD11c functions as an integrin alpha X subunit forming a heterodimer with the beta 2 subunit known as ITGB2. This complex is important for cell adhesion and migration processes. It mediates the binding of leukocytes to endothelial cells facilitating their migration from the bloodstream to sites of inflammation or infection. CD11c's presence on immune cells makes it essential for presenting antigens and initiating immune responses therefore having critical implications for immunity.
CD11c plays a significant role in the immune system particularly in the leukocyte adhesion and migration pathways. It partners with proteins like ITGB2 to mediate these functions. The signaling pathways involving CD11c and related molecules regulate leukocyte trafficking and activation ensuring proper localization and function at sites of damage or infection. These pathways are essential for maintaining immune homeostasis and prompt responses to pathogens.
CD11c has significant connections to autoimmune diseases and chronic inflammatory conditions. Aberrant CD11c expression or activity can contribute to the pathogenesis of conditions like rheumatoid arthritis where leukocyte migration and persistent inflammation play a role. Studies also link CD11c with proteins involved in these disorders highlighting its importance in disease progression and potential as a therapeutic target. The understanding of CD11c's role in these conditions can guide the development of treatments aimed at modulating immune responses.
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We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
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