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AB210308

FITC Anti-CD11c antibody [N418]

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(6 Publications)

Armenian hamster Monoclonal CD11c antibody - conjugated to FITC. Suitable for Flow Cyt and reacts with Mouse samples. Cited in 6 publications. Immunogen corresponding to Cell preparation containing Itgax protein.

View Alternative Names

CD11c, Integrin alpha-X, CD11 antigen-like family member C, Itgax

1 Images
Flow Cytometry - FITC Anti-CD11c antibody [N418] (AB210308)
  • Flow Cyt

Supplier Data

Flow Cytometry - FITC Anti-CD11c antibody [N418] (AB210308)

Flow cytometric analysis of C57Bl/6 splenocytes labeling CD11c with APC Anti-Mouse MHC Class II and ab210308 at 0.25 μg (right panel) or FITC Armenian Hamster IgG (left panel).

Key facts

Host species

Armenian hamster

Clonality

Monoclonal

Clone number

N418

Isotype

IgG

Conjugation

FITC

Excitation/Emission

Ex: 495nm, Em: 519nm

Carrier free

No

Reacts with

Mouse

Applications

Flow Cyt

applications

Immunogen

Cell preparation containing Itgax protein. The exact immunogen used to generate this antibody is proprietary information.

Q9QXH4

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p>Suggested use 0.25 μg.</p>" } } }
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Properties and storage information

Form
Liquid
Purification notes
ab210308 was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation.
Storage buffer
pH: 7.2 Preservative: 0.09% Sodium azide Constituents: 0.87% Sodium chloride, 0.12% Sodium dihydrogen phosphate, 0.1% Gelatin
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store in the dark
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CD11c also known as ITGAX is a subunit of integrin proteins that plays a pivotal role in immune cell function. This protein has a molecular mass of about 150 kDa and is primarily expressed on the surface of dendritic cells monocytes and macrophages. It serves as a marker for these cells commonly utilized in applications like CD11c flow cytometry and CD11c IHC. Researchers often study this target using CD11c antibodies to explore immune system dynamics and cell surface characteristics.
Biological function summary

CD11c functions as an integrin alpha X subunit forming a heterodimer with the beta 2 subunit known as ITGB2. This complex is important for cell adhesion and migration processes. It mediates the binding of leukocytes to endothelial cells facilitating their migration from the bloodstream to sites of inflammation or infection. CD11c's presence on immune cells makes it essential for presenting antigens and initiating immune responses therefore having critical implications for immunity.

Pathways

CD11c plays a significant role in the immune system particularly in the leukocyte adhesion and migration pathways. It partners with proteins like ITGB2 to mediate these functions. The signaling pathways involving CD11c and related molecules regulate leukocyte trafficking and activation ensuring proper localization and function at sites of damage or infection. These pathways are essential for maintaining immune homeostasis and prompt responses to pathogens.

CD11c has significant connections to autoimmune diseases and chronic inflammatory conditions. Aberrant CD11c expression or activity can contribute to the pathogenesis of conditions like rheumatoid arthritis where leukocyte migration and persistent inflammation play a role. Studies also link CD11c with proteins involved in these disorders highlighting its importance in disease progression and potential as a therapeutic target. The understanding of CD11c's role in these conditions can guide the development of treatments aimed at modulating immune responses.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis. Functions as a receptor of the erythrocyte-specific adhesion molecule ICAM4 and mediates erythrophagocytosis.
See full target information Itgax
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Publications (6)

Recent publications for all applications. Explore the full list and refine your search

Advanced healthcare materials 14:e2404548 PubMed39846276

2025

Endogenous Protein-Modified Gold Nanorods as Immune-Inert Biomodulators for Tumor-Specific Imaging and Therapy.

Applications

Unspecified application

Species

Unspecified reactive species

Chunyan Fang,Yueming Cai,Cui He,Ying Li,Lei He,Xiaoyan Wang,Yong Lu

Cancer immunology, immunotherapy : CII 72:2283-2297 PubMed36881132

2023

Targeting CD73 increases therapeutic response to immunogenic chemotherapy by promoting dendritic cell maturation.

Applications

Unspecified application

Species

Unspecified reactive species

Yun-Shan Lin,Shu-Fen Chiang,Chia-Yi Chen,Wei-Ze Hong,Tsung-Wei Chen,William Tzu-Liang Chen,Tao-Wei Ke,Pei-Chen Yang,Ji-An Liang,An-Cheng Shiau,K S Clifford Chao,Kevin Chih-Yang Huang

Frontiers in pharmacology 13:850187 PubMed35370707

2022

Qishen Granule (QSG) Inhibits Monocytes Released From the Spleen and Protect Myocardial Function via the TLR4-MyD88-NF-κB p65 Pathway in Heart Failure Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Yanqin Li,Xuan Li,Xu Chen,Xiaoqian Sun,Xiangning Liu,Gang Wang,Yizhou Liu,Lingwen Cui,Tianhua Liu,Wei Wang,Yong Wang,Chun Li

Oxidative medicine and cellular longevity 2021:9959746 PubMed34745428

2021

M1 Bone Marrow-Derived Macrophage-Derived Extracellular Vesicles Inhibit Angiogenesis and Myocardial Regeneration Following Myocardial Infarction via the MALAT1/MicroRNA-25-3p/CDC42 Axis.

Applications

Unspecified application

Species

Unspecified reactive species

Bairong Chen,Liyun Luo,Xiaoliang Wei,Dong Gong,Zhihui Li,Songbiao Li,Wenyi Tang,Lizi Jin

Journal of radiation research 61:851-859 PubMed32960261

2020

Radiation therapy enhanced therapeutic efficacy of anti-PD1 against gastric cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Sen Hong,MiaoMiao Bi,HaiYao Yu,ZhenKun Yan,HeLei Wang

Nature communications 9:2982 PubMed30061672

2018

Enhanced immunocompatibility of ligand-targeted liposomes by attenuating natural IgM absorption.

Applications

Unspecified application

Species

Unspecified reactive species

Juan Guan,Qing Shen,Zui Zhang,Zhuxuan Jiang,Yang Yang,Meiqing Lou,Jun Qian,Weiyue Lu,Changyou Zhan
View all publications
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Product promise

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