AB30350

FITC Anti-CD24 antibody [SN3]

Name: FITC Anti-CD24 antibody [SN3] (ab30350) | Abcam
Brand: Abcam Limited
SKU: AB30350
Price: 95 USD
Availability: InStock
Rating: 5 (1 reviews)

(1 Review)

(20 Publications)

Mouse Monoclonal CD24 antibody - conjugated to FITC. Suitable for Flow Cyt and reacts with Human samples. Cited in 20 publications.

View Alternative Names

CD24, CD24A, Signal transducer CD24, Small cell lung carcinoma cluster 4 antigen

1 Images

Flow Cytometry - FITC Anti-CD24 antibody [SN3] (AB30350)

Flow Cyt

Unknown

Flow Cytometry - FITC Anti-CD24 antibody [SN3] (AB30350)

Staining of human peripheral blood granulocytes with SN3 mouse monoclonal anti-human CD24 FITC conjugated (ab30350)

660 APC

APC Anti-CD24 antibody [SN3]
785 APC/Cy7®

APC/Cy7® Anti-CD24 antibody [SN3]
723 Alexa Fluor® 700

Alexa Fluor® 700 Anti-CD24 antibody [SN3]
578 PE

PE Anti-CD24 antibody [SN3]
578 PE

PE Anti-CD24 antibody [SN3]
695 PerCP/Cy5.5®

PerCP/Cy5.5® Anti-CD24 antibody [SN3]

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

SN3

Isotype

IgG1

Conjugation

FITC

Excitation/Emission

Ex: 495nm, Em: 519nm

Carrier free

Reacts with

Human

Applications

Flow Cyt

applications

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "20 µL for 10^6 Cells", "FlowCyt-species-notes": "1/1 - 1/10. Use 10μl of the above dilution for 106 cells or 100µl whole blood.<a href='/en-us/products/primary-antibodies/fitc-mouse-igg1-b11-6-isotype-control-ab91356'>ab91356</a> - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody." } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein G

Storage buffer

pH: 7.4 Preservative: 0.09% Sodium azide Constituents: PBS, 1% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

+4°C

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CD24 also known as heat-stable antigen or CD24A is a glycosylphosphatidylinositol (GPI)-anchored membrane protein with a molecular mass of approximately 30-50 kDa. It is expressed on the surface of many cell types including B cells T cells neutrophils and epithelial cells. CD24 plays a role in cell adhesion and signaling processes impacting immune response and cancer progression. Its expression is often used as a marker in identification and classification procedures such as flow cytometry.

Biological function summary

CD24 functions like a molecular "switch" modulating signals sent between cells. It acts as a ligand for multiple receptors and participates in cellular communication especially influencing the immune system. Part of its biological role involves interaction within cellular complexes impacting immune modulation and inflammatory responses. CD24's location at the interface of cellular microenvironments makes it critical for cellular response adaptation to varied external stimuli.

Pathways

CD24 participates in both immune signaling and cancer-related pathways. It plays a significant role in the suppression of the immune response often interacting with proteins like Siglec-10 in these pathways. CD24's involvement in these pathways contributes to cell survival and proliferation particularly within cancer development. The protein’s interaction within specified signaling pathways allows it to influence downstream targets that regulate gene expression and cellular functions.

CD24 has significant connections to cancer and inflammatory diseases. It is highly expressed in various cancers including breast and prostate cancer where it correlates with poor prognosis due to its role in apoptosis evasion and metastasis. CD24 interacts with proteins like HMGB1 and is implicated in inflammatory conditions where it modulates immune cell activity. Extensive research into CD24's involvement in these disorders may lead to targeted therapies including the development of anti-CD24 antibodies for therapeutic interventions.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
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Target data

May have a pivotal role in cell differentiation of different cell types. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells (PubMed : 11313396). In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. Plays a role in the control of autoimmunity (By similarity).

See full target information CD24

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Publications (20)

Recent publications for all applications. Explore the full list and refine your search

Journal of gastrointestinal oncology 14:1669-1693 PubMed37720449

2023

Esophageal cancer stem cells reduce hypoxia-induced apoptosis by inhibiting the GRP78-perk-eIF2α-ATF4-CHOP pathway .

Applications

Unspecified application

Species

Unspecified reactive species

Ruijiang Lin,Minjie Ma,Biao Han,Ya Zheng,Yuping Wang,Yongning Zhou

Immunomedicine 2: PubMed36816458

2023

Metabolic inhibitor screening identifies dihydrofolate reductase as an inducer of the tumor immune escape mediator CD24.

Applications

Unspecified application

Species

Unspecified reactive species

Austin C Boese,Jung Seok Hwang,Isabelle Young,Courteney M Malin,Vanessa Avalos,JiHoon Kang,Sumin Kang

Bioengineered 13:3896-3910 PubMed35109743

2022

Ultrasound targeted microbubble destruction-mediated SOCS3 attenuates biological characteristics and epithelial-mesenchymal transition (EMT) of breast cancer stem cells.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaojiang Tang,Na Hao,Yuhui Zhou,Yang Liu

Molecular medicine reports 24: PubMed34396431

2021

Chemosensitivity analysis and study of gene resistance on tumors and cancer stem cell isolates from patients with colorectal cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Elsa N Garza-Treviño,Herminia G Martínez-Rodríguez,Paulina Delgado-González,Orlando Solís-Coronado,Rocio Ortíz-Lopez,Adolfo Soto-Domínguez,Víctor M Treviño,Gerardo R Padilla-Rivas,Jose F Islas-Cisneros,Adriana G Quiroz-Reyes,Salvador L Said-Fernández

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 141:111815 PubMed34130123

2021

Single and double modified salinomycin analogs target stem-like cells in 2D and 3D breast cancer models.

Applications

Unspecified application

Species

Unspecified reactive species

Alicja Urbaniak,Megan R Reed,Daniel Fil,Anika Moorjani,Sarah Heflin,Michał Antoszczak,Michał Sulik,Adam Huczyński,Michalina Kupsik,Robert L Eoff,Melanie C MacNicol,Timothy C Chambers,Angus M MacNicol

Theranostics 10:10016-10030 PubMed32929331

2020

Targeted inhibition of KDM6 histone demethylases eradicates tumor-initiating cells via enhancer reprogramming in colorectal cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Junbao Zhang,Ying Ying,Meiqi Li,Maolin Wang,Xiaoyan Huang,Min Jia,Junhui Zeng,Canjie Ma,Yixiang Zhang,Chen Li,Xiaomei Wang,Xing-Sheng Shu

International journal of oncology 55:1003-1018 PubMed31545416

2019

Identification of new cancer stem cell markers and signaling pathways in HER‑2‑positive breast cancer by transcriptome sequencing.

Applications

Unspecified application

Species

Unspecified reactive species

Lu Feng,Shangke Huang,Gaili An,Guanying Wang,Shanzhi Gu,Xinhan Zhao

Behavioural brain research 365:48-55 PubMed30831140

2019

Neuroprotective effect of tanshinone IIA-incubated mesenchymal stem cells on Aβ-induced neuroinflammation.

Applications

Unspecified application

Species

Unspecified reactive species

Nanqu Huang,Yuanyuan Li,Yongjian Zhou,Yanjun Zhou,Fei Feng,Shangpeng Shi,Zhisheng Ba,Yong Luo

Oncology letters 16:5923-5929 PubMed30344742

2018

Doxorubicin resistance induces IL6 activation in the colon cancer cell line LS180.

Applications

Unspecified application

Species

Unspecified reactive species

Xiao-Yun Li,Xiao-Feng Liao,Hong-Bo Wang,Jian Zhang

International journal of molecular medicine 42:2193-2202 PubMed30015833

2018

Regenerative potential of human nucleus pulposus resident stem/progenitor cells declines with ageing and intervertebral disc degeneration.

Applications

Unspecified application

Species

Unspecified reactive species

Hao Wu,Yupan Shang,Jiayue Yu,Xiaoli Zeng,Jinhua Lin,Mei Tu,Lek Hang Cheang,Jiaqing Zhang

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

FITC Anti-CD24 antibody [SN3]

Flow Cytometry - FITC Anti-CD24 antibody [SN3] (AB30350)

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Key facts

Host species

Clonality

Clone number

Isotype

Conjugation

Excitation/Emission

Carrier free

Reacts with

Applications

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Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (20)

Product promise