Rat Monoclonal CD3d antibody - conjugated to FITC. Suitable for Flow Cyt and reacts with Mouse, Pig, Chicken, Monkey, Rhesus monkey, Human, Dog, Horse samples. Immunogen corresponding to Synthetic Peptide within Human CD3E.
pH: 7.4
Preservative: 0.09% Sodium azide
Constituents: PBS, 1% BSA
| Flow Cyt | |
|---|---|
| Human | Expected |
| Mouse | Expected |
| Chicken | Expected |
| Dog | Expected |
| Horse | Expected |
| Monkey | Expected |
| Pig | Expected |
| Rhesus monkey | Expected |
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info 1/5.00000 - 1/10.00000 | Notes ab18404 - Rat monoclonal IgG1, is suitable for use as an isotype control with this antibody. Use 10ul of the suggested working dilution to label 106 cells in 100ul. Membrane permeabilisation is required for this application. |
Species Pig | Dilution info 1/5.00000 - 1/10.00000 | Notes ab18404 - Rat monoclonal IgG1, is suitable for use as an isotype control with this antibody. Use 10ul of the suggested working dilution to label 106 cells in 100ul. Membrane permeabilisation is required for this application. |
Species Chicken | Dilution info 1/5.00000 - 1/10.00000 | Notes ab18404 - Rat monoclonal IgG1, is suitable for use as an isotype control with this antibody. Use 10ul of the suggested working dilution to label 106 cells in 100ul. Membrane permeabilisation is required for this application. |
Species Monkey | Dilution info 1/5.00000 - 1/10.00000 | Notes ab18404 - Rat monoclonal IgG1, is suitable for use as an isotype control with this antibody. Use 10ul of the suggested working dilution to label 106 cells in 100ul. Membrane permeabilisation is required for this application. |
Species Rhesus monkey | Dilution info 1/5.00000 - 1/10.00000 | Notes ab18404 - Rat monoclonal IgG1, is suitable for use as an isotype control with this antibody. Use 10ul of the suggested working dilution to label 106 cells in 100ul. Membrane permeabilisation is required for this application. |
Species Human | Dilution info 1/5.00000 - 1/10.00000 | Notes ab18404 - Rat monoclonal IgG1, is suitable for use as an isotype control with this antibody. Use 10ul of the suggested working dilution to label 106 cells in 100ul. Membrane permeabilisation is required for this application. |
Species Dog | Dilution info 1/5.00000 - 1/10.00000 | Notes ab18404 - Rat monoclonal IgG1, is suitable for use as an isotype control with this antibody. Use 10ul of the suggested working dilution to label 106 cells in 100ul. Membrane permeabilisation is required for this application. |
Species Horse | Dilution info 1/5.00000 - 1/10.00000 | Notes ab18404 - Rat monoclonal IgG1, is suitable for use as an isotype control with this antibody. Use 10ul of the suggested working dilution to label 106 cells in 100ul. Membrane permeabilisation is required for this application. |
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Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098). In addition of this role of signal transduction in T-cell activation, CD3D plays an essential role in thymocyte differentiation. Indeed, participates in correct intracellular TCR-CD3 complex assembly and surface expression. In absence of a functional TCR-CD3 complex, thymocytes are unable to differentiate properly. Interacts with CD4 and CD8 and thus serves to establish a functional link between the TCR and coreceptors CD4 and CD8, which is needed for activation and positive selection of CD4 or CD8 T-cells (PubMed:12215456).
CD3d, T3D, CD3D, T-cell surface glycoprotein CD3 delta chain, T-cell receptor T3 delta chain
Rat Monoclonal CD3d antibody - conjugated to FITC. Suitable for Flow Cyt and reacts with Mouse, Pig, Chicken, Monkey, Rhesus monkey, Human, Dog, Horse samples. Immunogen corresponding to Synthetic Peptide within Human CD3E.
pH: 7.4
Preservative: 0.09% Sodium azide
Constituents: PBS, 1% BSA
ab34722 recognises a highly conserved epitope of the CD3 molecule expressed by T lymphocytes.
We have tested this species and application combination and it works. It is covered by our product promise.
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
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