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Mouse Monoclonal CD31 antibody - conjugated to FITC. Suitable for Flow Cyt and reacts with Rat samples. Cited in 24 publications. Immunogen corresponding to Cell preparation containing CD31 protein.

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Key facts

Isotype

IgG1

Host species

Mouse

Conjugation

FITC

Excitation/Emission

Ex: 495nm, Em: 519nm

Storage buffer

pH: 7.4
Preservative: 0.09% Sodium azide
Constituents: PBS

Form

Liquid

Clonality

Monoclonal

Immunogen

  • Cell preparation containing CD31 protein. The exact immunogen used to generate this antibody is proprietary information. Database link Q3SWT0
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Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
Flow Cyt
Human
Not recommended
Rat
Tested

Tested
Tested

Species

Rat

Dilution info

10 µL for 106 Cells

Notes

Use 10μl for labeling 106 cells in 100μl.

ab91356 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.

Not recommended
Not recommended

Species

Human

Dilution info

-

Notes

Use 10μl for labeling 106 cells in 100μl.

ab91356 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.

Target data

Function

Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-660 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions. Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils. Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal. Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes. Modulates bradykinin receptor BDKRB2 activation. Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells. Induces susceptibility to atherosclerosis.

Alternative names

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Mouse Monoclonal CD31 antibody - conjugated to FITC. Suitable for Flow Cyt and reacts with Rat samples. Cited in 24 publications. Immunogen corresponding to Cell preparation containing CD31 protein.

Alternative names

Key facts

Isotype

IgG1

Conjugation

FITC

Excitation/Emission

Ex: 495nm, Em: 519nm

Form

Liquid

Clonality

Monoclonal

Immunogen
  • Cell preparation containing CD31 protein. The exact immunogen used to generate this antibody is proprietary information. Database link Q3SWT0
Clone number

TLD-3A12

Purification technique

Affinity purification Protein G

Specificity

Ab33858 recognises CD31 expressed primarily on endothelial cells, platelets and leucocytes.

Concentration
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Purification notes

Ab33858 was purified from tissue culture supernatant.

Storage

Shipped at conditions

Blue Ice

Appropriate long-term storage conditions

+4°C

Notes

This clone (TLD 3A12) has been shown to partially block the proliferative response of antigen specific CD4+ T cells to antigen presenting cells and relevant antigen.

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

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Product promise

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2 product images

  • Flow Cytometry - FITC Anti-CD31 antibody [TLD-3A12] (ab33858), expandable thumbnail

    Flow Cytometry - FITC Anti-CD31 antibody [TLD-3A12] (ab33858)

    Figure A. RPE conjugated mouse anti rat TCRa/b and FITC conjugated mouse IgG1 isotype control. Figure B. RPE conjugated mouse anti rat TCRa/b and ab33858. All experiments performed on red cell lysed rat blood gated on mononuclear cells.

  • Flow Cytometry - FITC Anti-CD31 antibody [TLD-3A12] (ab33858), expandable thumbnail

    Flow Cytometry - FITC Anti-CD31 antibody [TLD-3A12] (ab33858)

    Figure A. ab33858 and RPE conjugated mouse IgG1 isotype control. Figure B. ab33858 and RPE conjugated mouse anti rat TCRa/b. All experiments performed on red cell lysed rat blood gated on mononuclear cells.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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