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AB218745

FITC Anti-CD4 antibody [GK1.5]

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(5 Publications)

Rat Monoclonal CD4 antibody - conjugated to FITC. Suitable for Flow Cyt and reacts with Mouse samples. Cited in 5 publications.

View Alternative Names

CD4, T-cell surface glycoprotein CD4, T-cell differentiation antigen L3T4, T-cell surface antigen T4/Leu-3, Cd4

1 Images
Flow Cytometry - FITC Anti-CD4 antibody [GK1.5] (AB218745)
  • Flow Cyt

Supplier Data

Flow Cytometry - FITC Anti-CD4 antibody [GK1.5] (AB218745)

Flow cytometric analysis of C57Bl/6 splenocytes labeling CD4 with 0.25 ug ab218745 (solid line) or 0.25 ug Rat IgG2b FITC isotype control (dashed line).

Key facts

Host species

Rat

Clonality

Monoclonal

Clone number

GK1.5

Isotype

IgG2b

Light chain type

kappa

Conjugation

FITC

Excitation/Emission

Ex: 495nm, Em: 519nm

Carrier free

No

Reacts with

Mouse

Applications

Flow Cyt

applications

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Purification notes
ab218745 was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation.
Storage buffer
pH: 7.2 Preservative: 0.09% Sodium azide Constituents: 0.87% Sodium chloride, 0.12% Sodium dihydrogen phosphate, 0.1% Gelatin
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store in the dark
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule : peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages.
See full target information Cd4
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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Experimental and therapeutic medicine 25:271 PubMed37206552

2023

Changes in the balance of Th17/Treg cells and oxidative stress markers in patients with HIV‑associated pulmonary tuberculosis who develop IRIS.

Applications

Unspecified application

Species

Unspecified reactive species

Long Wen,Lei Shi,Shan-Shan Wan,Tao Xu,Lei Zhang,Zhi-Guo Zhou

Journal of oncology 2022:8890434 PubMed35664563

2022

Bone Mesenchymal Stem Cell-Derived Exosome-Enclosed miR-181a Induces CD4CD25FOXP3 Regulatory T Cells via SIRT1/Acetylation-Mediated FOXP3 Stabilization.

Applications

Unspecified application

Species

Unspecified reactive species

Renyong Wang,Ruixue Li,Tiehan Li,Lei Zhu,Zongze Qi,Xiaokui Yang,Huan Wang,Baoquan Cao,Hong Zhu

Nephron 146:528-538 PubMed35176745

2022

Losartan Attenuates Atherosclerosis in Uremic Mice by Regulating Treg/Th17 Balance via Mediating PTEN/PI3K/Akt Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Shanzhai Wei,Jie Sun,Yibei Li,Kangchun Xu,Man Wang,Yilai Zhang

BMC endocrine disorders 21:57 PubMed33781239

2021

Acacetin ameliorates insulin resistance in obesity mice through regulating Treg/Th17 balance via MiR-23b-3p/NEU1 Axis.

Applications

Unspecified application

Species

Unspecified reactive species

Yan Wei,Jianhong Jing,Zhiping Peng,Xiaoqian Liu,Xueyang Wang

Medical science monitor : international medical jo 25:4655-4664 PubMed31230061

2019

Effect of Dexmedetomidine-Mediated Insulin-Like Growth Factor 2 (IGF2) Signal Pathway on Immune Function and Invasion and Migration of Cancer Cells in Rats with Ovarian Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Hang Tian,Lei Hou,Yumei Xiong,Qiuju Cheng,Junking Huang
View all publications
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Product promise

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