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AB86886

FITC Anti-CD4 antibody [RPA-T4]

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(1 Publication)

Anti-CD4 antibody [RPA-T4] conjugated to FITC - suitable for flow cytometry, and reacts with human samples. Clone [RPA-T4] is a mouse monoclonal antibody and one of the most commonly used clones for flow cytometry.

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1 Images
Flow Cytometry - FITC Anti-CD4 antibody [RPA-T4] (AB86886)
  • Flow Cyt

Supplier Data

Flow Cytometry - FITC Anti-CD4 antibody [RPA-T4] (AB86886)

Flow cytometry analysis showing human peripheral blood lymphocytes stained with ab86886 at 1μg (solid line). FITC Mouse IgG1 (1μg) was used as isotype contol (dashed line).

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Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

RPA-T4

Isotype

IgG1

Light chain type

kappa

Conjugation

FITC

Excitation/Emission

Ex: 495nm, Em: 519nm

Carrier free

No

Reacts with

Human

Applications

Flow Cyt

applications

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "10 µL for 10^6 Cells", "FlowCyt-species-notes": "<p><a href='/en-us/products/primary-antibodies/fitc-mouse-igg1-kappa-mopc-21-isotype-control-ab106163'>ab106163</a> - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Storage buffer
pH: 7.2 Preservative: 0.09% Sodium azide Constituents: 0.87% Sodium chloride, 0.16% Sodium phosphate, 0.1% Gelatin
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule : peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages.. (Microbial infection) Primary receptor for human immunodeficiency virus-1 (HIV-1) (PubMed : 12089508, PubMed : 16331979, PubMed : 2214026, PubMed : 9641677). Down-regulated by HIV-1 Vpu (PubMed : 17346169). Acts as a receptor for Human Herpes virus 7/HHV-7 (PubMed : 7909607).
See full target information CD4

Alternative Names

CD4, T-cell surface glycoprotein CD4, T-cell surface antigen T4/Leu-3
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Publications (1)

Recent publications for all applications. Explore the full listand refine your search

Annals of clinical and translational neurology 2:894-905 PubMed26401511

2015

cFLIP overexpression in T cells in thymoma-associated myasthenia gravis.

Applications

Flow Cyt

Species

Human

Djeda Belharazem,Berthold Schalke,Ralf Gold,Wilfred Nix,Mario Vitacolonna,Peter Hohenberger,Eric Roessner,Torsten J Schulze,Güher Saruhan-Direskeneli,Vuslat Yilmaz,German Ott,Philipp Ströbel,Alexander Marx
View all publications
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Product promise

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