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AB275943

FITC Anti-CD79a antibody [HM57]

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(1 Publication)

Mouse Monoclonal CD79A antibody - conjugated to FITC. Suitable for Flow Cyt (Intra) and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human CD79A aa 200 to C-terminus.

View Alternative Names

CD79a, IGA, MB1, CD79A, B-cell antigen receptor complex-associated protein alpha chain, Ig-alpha, MB-1 membrane glycoprotein, Membrane-bound immunoglobulin-associated protein, Surface IgM-associated protein

3 Images
Flow Cytometry (Intracellular) - FITC Anti-CD79a antibody [HM57] (AB275943)
  • Flow Cyt (Intra)

Unknown

Flow Cytometry (Intracellular) - FITC Anti-CD79a antibody [HM57] (AB275943)

Separation of human CD79a positive B cells (red-filled) from neutrophil granulocytes (black-dashed) in Intracellular Flow Cytometry analysis (intracellular staining) of human peripheral whole blood stained using ab275943 (4 ul reagent / 100 ul of peripheral whole blood).

Flow Cytometry (Intracellular) - FITC Anti-CD79a antibody [HM57] (AB275943)
  • Flow Cyt (Intra)

Unknown

Flow Cytometry (Intracellular) - FITC Anti-CD79a antibody [HM57] (AB275943)

Flow cytometry intracellular staining pattern of human peripheral whole blood stained using ab275943 (4 ul reagent / 100 ul of peripheral whole blood).

Flow Cytometry (Intracellular) - FITC Anti-CD79a antibody [HM57] (AB275943)
  • Flow Cyt (Intra)

Unknown

Flow Cytometry (Intracellular) - FITC Anti-CD79a antibody [HM57] (AB275943)

Flow cytometry multicolor surface staining pattern of human lymphocytes using a anti-human CD-19 antibody (10 ul reagent / 100 ul of peripheral whole blood) and intracellular staining of human lymphocytes using ab275943 (4 ul reagent / 100 ul of peripheral whole blood).

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

HM57

Isotype

IgG1

Conjugation

FITC

Excitation/Emission

Ex: 495nm, Em: 519nm

Carrier free

No

Reacts with

Human

Applications

Flow Cyt (Intra)

applications

Immunogen

Synthetic Peptide within Human CD79A aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P11912

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Primary Antibodies

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Primary Antibodies

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCytIntra" : {"fullname" : "Flow Cytometry (Intracellular)", "shortname":"Flow Cyt (Intra)"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCytIntra-species-checked": "testedAndGuaranteed", "FlowCytIntra-species-dilution-info": "", "FlowCytIntra-species-notes": "<p>4 μl reagent / 100 μl of peripheral whole blood.</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Size-exclusion chromatography
Storage buffer
Preservative: 0.1% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Do Not Freeze|Store in the dark
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CD79a also known as Ig-alpha or MB-1 is a component of the B cell antigen receptor (BCR) complex. It is a transmembrane protein with a molecular mass of approximately 47 kDa. CD79a is part of a heterodimer with CD79b and is mainly expressed on the surface of B lymphocytes. This protein plays a critical mechanical role in signaling transduction through the BCR by associating with membrane-bound immunoglobulin molecules helping to initiate the immune response upon antigen binding.
Biological function summary

This protein acts as an essential mediator in the immune system. CD79a together with CD79b forms part of the BCR complex critical for B cell development and maturation. The BCR complex activates signaling cascades that influence B cell fate decisions such as proliferation differentiation and apoptosis. By transmitting signals from the BCR CD79a helps regulate these cellular functions necessary for efficient immune defense.

Pathways

CD79a plays a pivotal role in the B cell receptor signaling pathway. This pathway involves signaling molecules such as spleen tyrosine kinase (SYK) and phosphoinositide 3-kinase (PI3K) which are activated upon BCR engagement. CD79a acts in concert with other proteins including CD79b and the IgM receptor facilitating downstream signaling cascades that ensure proper B cell responses. Its role is important for linking extracellular antigen recognition to intracellular signaling events.

CD79a is significant in conditions like B cell lymphomas and certain immunodeficiencies. Abnormal expression or mutations in CD79a are associated with some types of non-Hodgkin lymphoma. The protein's interaction with CD79b is particularly relevant as alterations in these proteins' function or expression can impact B cell development and lead to pathogenesis in lymphoproliferative disorders. Consequently CD79a serves as an important biomarker and potential therapeutic target in these diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells.
See full target information CD79A
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cell reports 43:113866 PubMed38416638

2024

Atypical cofilin signaling drives dendritic cell migration through the extracellular matrix via nuclear deformation.

Applications

Unspecified application

Species

Unspecified reactive species

Harry Warner,Giulia Franciosa,Guus van der Borg,Britt Coenen,Felix Faas,Claire Koenig,Rinse de Boer,René Classens,Sjors Maassen,Maksim V Baranov,Shweta Mahajan,Deepti Dabral,Frans Bianchi,Niek van Hilten,Herre Jelger Risselada,Wouter H Roos,Jesper Velgaard Olsen,Laia Querol Cano,Geert van den Bogaart
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Product promise

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