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AB48318

FITC Anti-CD83 antibody [Michel-19]

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(1 Publication)

Rat Monoclonal CD83 antibody - conjugated to FITC. Suitable for Flow Cyt and reacts with Transfected cell line samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Mouse Cd83.

View Alternative Names

CD83, CD83 antigen, mCD83, Cd83

1 Images
Flow Cytometry - FITC Anti-CD83 antibody [Michel-19] (AB48318)
  • Flow Cyt

Supplier Data

Flow Cytometry - FITC Anti-CD83 antibody [Michel-19] (AB48318)

Flow cytometry analysis of transfected mCD83 cells labelling CD83 with ab48318 at ≤1.0 μg per million cells in 100 μl volume.

Key facts

Host species

Rat

Clonality

Monoclonal

Clone number

Michel-19

Isotype

IgG1

Light chain type

kappa

Conjugation

FITC

Excitation/Emission

Ex: 495nm, Em: 519nm

Carrier free

No

Applications

Flow Cyt

applications

Immunogen

Recombinant Full Length Protein corresponding to Mouse Cd83.

O88324

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Alternative Products

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Complementary Products

Assay Kits

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Primary Antibodies

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Secondary Antibodies

AB150113

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Transfected cell line": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p><a href='/en-us/products/primary-antibodies/fitc-rat-igg1-kappa-rtk2071-isotype-control-ab18404'>ab18404</a> - Rat monoclonal IgG1, is suitable for use as an isotype control with this antibody.</p><p>The suggested use of this antibody is ≤1.0 μg per million cells in 100 μl volume.</p>" } } }
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Product details

Conjugated with FITC under optimal conditions. The solution is free of unconjugated FITC.
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.09% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CD83 also known as 3D11 in some contexts is a protein with important roles in the immune system. The CD83 protein is a glycoprotein with a molecular mass of approximately 45 kDa. It is expressed in various immune cells including dendritic cells B cells thymic epithelial cells and activated T cells. CD83 acts as a surface marker during the maturation and activation of these cells. This characteristic makes it a useful marker in immunological studies often referred to by scientists as the CD83 marker.
Biological function summary

The primary role of CD83 involves the regulation of immune responses. It functions by modulating the activity and communication of immune cells especially impacting the antigen-presenting capabilities of dendritic cells. CD83 also plays a role in promoting the maturation of these cells and influencing T-cell responses. Although CD83 is not generally recognized as a part of a complex its interactions with other cell surface molecules are significant for immune system function.

Pathways

CD83 has notable involvement in immune signaling pathways including the NF-kB and JAK/STAT pathways. These pathways are critical for transmitting signals that influence cell survival proliferation and activation. Through these pathways CD83 interacts with proteins such as cytokines and growth factors which further modulate their effects on immune cells and their responses.

Understanding CD83’s role provides insights into conditions like autoimmune diseases and immune deficiencies. In autoimmune diseases irregular expression or function of CD83 can disrupt normal immune response contributing to pathogenesis. Its relationship with other proteins such as CD28 in T-cell activation underlies its involvement in disorders characterized by immune dysregulation. Furthermore CD83 expression profiles may help decipher cancer immune evasion mechanisms providing possible therapeutic targets.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Transmembrane glycoprotein predominantly found on the surface of many immune cells including dendritic cells or lymphocytes that plays various roles in immune response regulation. Plays an essential role in CD4(+) T-selection, differentiation and stability by regulating the activity of the major E3 ubiquitin ligase responsible for controlling MHC II trafficking MARCHF8 (PubMed : 27503071, PubMed : 27503069). Also inhibits MARCHF1 association with MHC II and ubiquitination of MHCII (By similarity). In addition, acts as an important modulator of protective responses against acute infections (PubMed : 31527313).
See full target information Cd83
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Medicine 97:e11293 PubMed29953011

2018

Prevalence and factors associated with nonalcoholic fatty pancreas disease and its severity in China.

Applications

Unspecified application

Species

Unspecified reactive species

Siying Weng,Jianyang Zhou,Xiabo Chen,Yihong Sun,Zhujun Mao,Kefu Chai
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Product promise

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