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AB281950

FITC Anti-H7N9 Hemagglutinin antibody [002]

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Rabbit Recombinant Monoclonal H7N9 Hemagglutinin antibody - conjugated to FITC. Suitable for Flow Cyt and reacts with Transfected cell line - H7N9 subtype samples.
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Flow Cytometry - FITC Anti-H7N9 Hemagglutinin antibody [002] (AB281950)
  • Flow Cyt

Supplier Data

Flow Cytometry - FITC Anti-H7N9 Hemagglutinin antibody [002] (AB281950)

Flow cytometric analysis of HEK-293 (Human epithelial cell line from embryonic kidney) cells transfected with plasmid DNA of H7N9 (A/Anhui/1/2013) Hemagglutinin using ab281950 at 0.1 mg/ml (black) compared to an isotype control (gray).

Cells were collected at 72 hours post-transfection, and the cell surface expression of HA were measured by flow cytometry.

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

002

Isotype

IgG

Conjugation

FITC

Excitation/Emission

Ex: 495nm, Em: 519nm

Carrier free

No

Reacts with

H7N9 subtype

Applications

Flow Cyt

applications

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "H7N9 subtype": { "FlowCyt-species-checked": "predicted", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "" }, "Transfected cell line - H7N9 subtype": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "0.1 µg/mL", "FlowCyt-species-notes": "<p>10 μl per test.</p>" } } }
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Product details

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
Preservative: 0.1% Sodium azide Constituents: 0.5% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store in the dark
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

H7N9 Hemagglutinin also known simply as HA is a glycoprotein important for the entry of the influenza A virus into host cells. It facilitates viral attachment to host cell receptors by binding to sialic acid residues which triggers endocytosis and eventual viral fusion with the host membrane. H7N9 Hemagglutinin has a molecular mass of approximately 75 kDa. It is expressed on the surface of the viral envelope and undergoes a conformational change which is pH-dependent required for fusion with host cell membranes.
Biological function summary

Hemagglutinin plays an essential role in viral infectivity and propagation. As part of the influenza virus surface glycoproteins complex along with neuraminidase it not only aids in viral entry but also influences the immune recognition by the host organism. Hemagglutinin's structure is an important determinant of host specificity and antigenic variation which affects how the immune system identifies and responds to viral infections making it important in immune evasion.

Pathways

H7N9 Hemagglutinin participates in viral entry processes and immune response pathways including antigen processing and presentation. It is closely associated with sialic acid metabolism as it determines the binding specificity and efficiency to different host cells. Its actions are often linked to other viral proteins like neuraminidase which assists in the release of new viral particles albeit with a contrasting function of cleaving sialic acid residues from glycoproteins.

H7N9 Hemagglutinin is associated mainly with influenza A specifically highly pathogenic avian influenza infections and potential zoonotic transmissions. These infections can lead to severe respiratory diseases often linked with high morbidity and mortality in humans. It works in conjunction with other influenza proteins such as neuraminidase contributing to the virus's ability to spread and cause disease in various hosts. Understanding hemagglutinin's role can aid in developing vaccines and therapeutic targets to control and prevent influenza outbreaks.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information H7N9 Hemagglutinin
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Product promise

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