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AB20437

FITC Anti-HSV1 antibody

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(2 Publications)

Goat Polyclonal HSV1 antibody - conjugated to FITC. Suitable for ELISA, ICC/IF and reacts with Herpes simplex virus samples. Cited in 2 publications. Immunogen corresponding to Virus preparation containing HSV1 protein.

Key facts

Host species

Goat

Clonality

Polyclonal

Isotype

IgG

Conjugation

FITC

Excitation/Emission

Ex: 495nm, Em: 519nm

Carrier free

No

Reacts with

Herpes simplex virus

Applications

ELISA, ICC/IF

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

Specificity

ICPs and late structural (virion) antigens.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Herpes simplex virus": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "1/10 - 1/50", "ELISA-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>" } } }
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Product details

IgG fraction covalently coupled with high purity Isomer I of fluorescein isothiocyanate. Care is taken to ensure complete removal of any free fluorescein from the final product.
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Properties and storage information

Form
Liquid
Purity
IgG fraction
Storage buffer
Preservative: 0.1% Sodium azide Constituents: PBS, 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Herpes Simplex Virus 1 (HSV1) also referred to as HSV-1 is an enveloped virus with a large double-stranded DNA genome of about 152 kb. HSV1 possesses a complex architecture featuring numerous glycoproteins including gHSV1 that play significant roles in its entry and immune evasion. This virus predominantly targets epithelial cells in the oral genital regions and sensory neurons. HSV1 expresses various proteins vital for its replication and viral particle assembly within host cells.
Biological function summary

HSV1 interacts with the host's cellular mechanisms to establish latency and persistent infection. During infection several HSV1 proteins contribute to its ability to subvert and evade the host immune response sometimes forming part of existing viral protein complexes. Virion-host cell membrane fusion facilitated by glycoprotein gHSV1 is an important step allowing the viral genome to enter the host cell driving subsequent viral replication.

Pathways

The life cycle of HSV1 includes entry replication and egress tightly integrated into cellular pathways like the apoptosis and the interferon response pathways. HSV1 modulates the apoptotic pathway through proteins such as ICP22 which allows survival and efficient viral replication. Also it influences the interferon response pathway by inhibiting the host's antiviral mechanisms ensuring viral persistence in the host.

HSV1 is most commonly known to cause oral herpes and can lead to encephalitis in severe cases. The virus reactivates from latency within neurons potentially leading to periodic disease recurrence. During infection HSV1 interacts with host proteins such as TNF-alpha which can contribute to inflammatory responses and ICP0 which facilitates viral replication and disrupts host cell function. Understanding HSV1's mechanisms and pathways is critical for developing effective anti-HSV-1 antibodies and therapeutic strategies.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information HSV1
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Pediatric rheumatology online journal 22:73 PubMed39118148

2024

Increased vascular deposition of oxidized LDL in untreated juvenile dermatomyositis.

Applications

Unspecified application

Species

Unspecified reactive species

Jacob C Spitznagle,Akadia Kacha-Ochana,Joan M Cook-Mills,Gabrielle A Morgan,Lauren M Pachman

Molecules (Basel, Switzerland) 26: PubMed34641603

2021

Anti-Herpes Simplex 1 Activity of (Jojoba) Wax.

Applications

Unspecified application

Species

Unspecified reactive species

Zipora Tietel,Sarit Melamed,Noy Eretz-Kdosha,Ami Guetta,Raanan Gvirtz,Navit Ogen-Shtern,Arnon Dag,Guy Cohen
View all publications
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Product promise

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