AB34176

FITC Anti-Integrin alpha 1 antibody [TS2/7]

Name: Anti-Integrin alpha 1 FITC antibody [TS2/7] (ab34176) IgG1 | Abcam
Brand: Abcam Limited
SKU: AB34176
Price: 165 USD
Availability: InStock

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(4 Publications)

Mouse Monoclonal Integrin alpha 1 antibody - conjugated to FITC. Suitable for Flow Cyt and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Cell preparation containing ITGA1 protein.

View Alternative Names

CD49a, Integrin alpha-1, CD49 antigen-like family member A, Laminin and collagen receptor, VLA-1, ITGA1

1 Images

Flow Cytometry - FITC Anti-Integrin alpha 1 antibody [TS2/7] (AB34176)

Flow Cyt

Supplier Data

Flow Cytometry - FITC Anti-Integrin alpha 1 antibody [TS2/7] (AB34176)

Flow Cytometry analysis of HeLa cells labeling Integrin alpha 1 with ab34176.

Unconjugated

Anti-Integrin alpha 1 antibody [TS2/7]

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

TS2/7

Isotype

IgG1

Conjugation

FITC

Excitation/Emission

Ex: 495nm, Em: 519nm

Carrier free

Reacts with

Human

Applications

Flow Cyt

applications

Immunogen

Cell preparation containing ITGA1 protein. The exact immunogen used to generate this antibody is proprietary information.

P56199

Specificity

This antibody recognises the human alpha 1 integrin subunit.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "1/1 - 1/5", "FlowCyt-species-notes": "<p><a href='/en-us/products/primary-antibodies/fitc-mouse-igg1-b11-6-isotype-control-ab91356'>ab91356</a> - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.</p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein G

Purification notes

Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant

Storage buffer

pH: 7.4 Preservative: 0.09% Sodium azide Constituents: PBS, 1% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

+4°C

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Integrin alpha 1 also called CD49a is a protein that functions as a mechanical link between cells and the extracellular matrix. It is part of the integrin protein family and partners with beta 1 integrin to form the integrin alpha 1 beta 1 complex. This protein is a heterodimer and weighs approximately 180 kDa. The integrin alpha 1 is expressed in various tissues including the dermis cartilage and the immune system especially on activated T cells and natural killer cells.

Biological function summary

Integrin alpha 1 beta 1 mediates cell adhesion and migration. It plays an important role in collagen binding influencing various cellular processes like proliferation and differentiation. Integrin alpha 1 forms a complex with ligand molecules notably collagen which assists in remodeling the extracellular matrix. This activity contributes to the development and repair of tissues offering structural support and pathways for cell signaling events.

Pathways

Integrin alpha 1 engages in the MAPK signaling pathway and regulation of the TGF-beta signaling cascade. By mediating interactions between cells and their environment it influences downstream signaling and gene expression. Integrins including integrin alpha 1 have roles in pathways related to cellular stress responses and signal modulation interacting with proteins such as fibronectin within these processes.

Integrin alpha 1 has been linked to fibrosis and chronic inflammatory diseases. By modulating matrix-related signals it influences the pathology of fibrosis through upregulation of matrix metalloproteinases. In chronic inflammatory diseases its interaction with collagen and other matrix proteins can affect immune cell trafficking and signaling. Understanding these connections helps in exploring potential therapeutic targets and interventions.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth.

See full target information ITGA1

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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 16:6870 PubMed40715114

2025

Mammalian cells measure the extracellular matrix area and respond through switching the adhesion state.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaole Wang,Pengli Wang,Lihang Zhang,Tianyu Xu,Seungkuk Ahn,Upnishad Sharma,Han Yu,Nico Strohmeyer,Daniel J Müller

Antioxidants (Basel, Switzerland) 11: PubMed36139739

2022

AMPK-Nrf2 Signaling Pathway in Phrenic Motoneurons following Cervical Spinal Cord Injury.

Applications

Unspecified application

Species

Unspecified reactive species

Pauline Michel-Flutot,Laurie Efthimiadi,Lynda Djerbal,Therese B Deramaudt,Marcel Bonay,Stéphane Vinit

Annals of the rheumatic diseases 69:270-5 PubMed19279017

2009

Transforming growth factor beta1 and laminin-111 cooperate in the induction of interleukin-16 expression in synovial fibroblasts from patients with rheumatoid arthritis.

Applications

Unspecified application

Species

Unspecified reactive species

K Warstat,M Hoberg,M Rudert,S Tsui,T Pap,B Angres,M Essl,T J Smith,W W Cruikshank,G Klein,S Gay,W K Aicher

The Journal of biological chemistry 280:13848-57 PubMed15647274

2005

A streptococcal collagen-like protein interacts with the alpha2beta1 integrin and induces intracellular signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Joseph O Humtsoe,Jiyeun K Kim,Yi Xu,Douglas R Keene,Magnus Höök,Slawomir Lukomski,Kishore K Wary

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

FITC Anti-Integrin alpha 1 antibody [TS2/7]

Flow Cytometry - FITC Anti-Integrin alpha 1 antibody [TS2/7] (AB34176)

Related conjugates and formulations (1)

Key facts

Host species

Clonality

Clone number

Isotype

Conjugation

Excitation/Emission

Carrier free

Reacts with

Applications

Immunogen

Specificity

Reactivity data

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (4)

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