AB30486

FITC Anti-Integrin alpha 2 antibody [AK7]

Name: Anti-Integrin alpha 2 FITC antibody [AK7] (ab30486) IgG1 | Abcam
Brand: Abcam Limited
SKU: AB30486
Price: 535 USD
Availability: InStock

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(4 Publications)

Mouse Monoclonal Integrin alpha 2 antibody - conjugated to FITC. Suitable for Flow Cyt and reacts with Human, Monkey samples. Cited in 4 publications.

View Alternative Names

CD49b, CD49B, ITGA2, Integrin alpha-2, CD49 antigen-like family member B, Collagen receptor, Platelet membrane glycoprotein Ia, VLA-2 subunit alpha, GPIa

1 Images

Flow Cytometry - FITC Anti-Integrin alpha 2 antibody [AK7] (AB30486)

Flow Cyt

Unknown

Flow Cytometry - FITC Anti-Integrin alpha 2 antibody [AK7] (AB30486)

Flow cytometric analysis of human peripheral blood platlets with 10μl for 10⁶ cells of anti human CD49b FITC conjugated (ab30486).

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

AK7

Isotype

IgG1

Conjugation

FITC

Excitation/Emission

Ex: 495nm, Em: 519nm

Carrier free

Reacts with

Human, Monkey

Applications

Flow Cyt

applications

Specificity

ab30486 recognises the integrin alpha 2 subunit, which is a 160kD glycoprotein that non covalently associates with the 130kD integrin beta 1 subunit (CD29) to form the VLA2 complex.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "1/1 - 1/5", "FlowCyt-species-notes": "<p><a href='/en-us/products/primary-antibodies/fitc-mouse-igg1-b11-6-isotype-control-ab91356'>ab91356</a> - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.</p>" }, "Monkey": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "1/1 - 1/5", "FlowCyt-species-notes": "<p><a href='/en-us/products/primary-antibodies/fitc-mouse-igg1-b11-6-isotype-control-ab91356'>ab91356</a> - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.</p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein G

Storage buffer

pH: 7.4 Preservative: 0.09% Sodium azide Constituents: PBS, 1% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

+4°C

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Integrin alpha 2 also known as CD49b ITGA2 and A2 is a protein that functions as part of the integrin family. Integrins are transmembrane receptors that facilitate cell-extracellular matrix adhesion. Integrin alpha 2 has a molecular mass of approximately 130 kDa and is widely expressed in epithelial cells fibroblasts and platelets. This protein is important for mediating adhesion between cells and the extracellular matrix affecting cell signaling and behavior. Through this adhesion cells can communicate with their environment adjusting their functions accordingly.

Biological function summary

Integrin alpha 2 plays a significant role in cellular processes like migration and proliferation. It forms a heterodimer complex by pairing with the beta 1-integrin subunit contributing to its adhesive and signaling functions. This association enables the integrin alpha 2 complex to bind specific extracellular matrix components such as collagen and laminin. Through these interactions it regulates processes like wound healing and tissue remodeling and affects how cells respond to mechanical stress.

Pathways

Integrin alpha 2 is involved in major signaling routes that influence cell fate and movement. Notably it participates in the PI3K/AKT and MAPK pathways which are important for regulating cell growth and survival. It interacts with signaling proteins like focal adhesion kinase (FAK) and Src family kinases linking extracellular matrix changes to intracellular responses. These pathways help in transmitting signals that coordinate the cell's structural and functional adjustments in response to its surroundings.

Integrin alpha 2 has connections to cancer and fibrosis. In cancers its altered expression may contribute to tumor progression and metastasis often involving interactions with other integrins and matrix metalloproteinases that degrade extracellular components. In fibrosis excessive integrin alpha 2 activity can lead to abnormal tissue remodeling and scarring implicating its role alongside collagen-producing cells. Understanding these connections is vital for developing therapies targeting integrin-mediated pathways in these diseases.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.. (Microbial infection) Integrin ITGA2 : ITGB1 acts as a receptor for Human rotavirus A.. (Microbial infection) Integrin ITGA2 : ITGB1 acts as a receptor for Human echoviruses 1 and 8.

See full target information ITGA2

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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Journal of cellular and molecular medicine 24:13853-13862 PubMed33124775

2020

The stiffness-controlled release of interleukin-6 by cardiac fibroblasts is dependent on integrin α2β1.

Applications

Unspecified application

Species

Unspecified reactive species

Małgorzata Gałdyszyńska,Justyna Bobrowska,Małgorzata Lekka,Paulina Radwańska,Lucyna Piera,Jacek Szymański,Jacek Drobnik

Radiation oncology (London, England) 7:59 PubMed22500976

2012

Cancer-associated fibroblasts from human NSCLC survive ablative doses of radiation but their invasive capacity is reduced.

Applications

Flow Cyt

Species

Human

Turid Hellevik,Ingvild Pettersen,Vivian Berg,Jan Olof Winberg,Bjørn T Moe,Kristian Bartnes,Ruth H Paulssen,Lill-Tove Busund,Roy Bremnes,Anthony Chalmers,Iñigo Martinez-Zubiaurre

Cell transplantation 21:175-89 PubMed21294955

2011

Autologous lung-derived mesenchymal stem cell transplantation in experimental emphysema.

Applications

Unspecified application

Species

Unspecified reactive species

Edward P Ingenito,Larry Tsai,Shankar Murthy,Shivraj Tyagi,Melissa Mazan,Andrew Hoffman

Journal of tissue engineering and regenerative medicine 4:259-72 PubMed20020503

2009

Design and testing of biological scaffolds for delivering reparative cells to target sites in the lung.

Applications

Unspecified application

Species

Unspecified reactive species

Edward P Ingenito,Elif Sen,Larry W Tsai,Shankar Murthy,Andrew Hoffman

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

FITC Anti-Integrin alpha 2 antibody [AK7]

Flow Cytometry - FITC Anti-Integrin alpha 2 antibody [AK7] (AB30486)

Key facts

Host species

Clonality

Clone number

Isotype

Conjugation

Excitation/Emission

Carrier free

Reacts with

Applications

Specificity

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (4)

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