AB4211

FITC Anti-Lambda Light chain antibody

Name: Anti-Lambda Light chain FITC antibody (ab4211) IgG | Abcam
Brand: Abcam Limited
SKU: AB4211
Price: 535 USD
Availability: InStock

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(1 Publication)

Rabbit Polyclonal Lambda Light chain antibody - conjugated to FITC. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication.

View Alternative Names

BJP, Bence Jones protein, Constant region of lambda light chains, IGLC, IGLC 2, IGLC 3, IGLC6, IGLV, Ig lambda chain C regions, Immunoglobulin lambda constant 1, Immunoglobulin lambda constant regin 1, Immunoglobulin lambda locus, Immunoglobulin lambda variable cluster, Immunoglobulin: lambda light chain, Mcg marker, Paraprotein, ig lambda-6 chain C region, immunoglobulin lambda gene cluster

1 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - FITC Anti-Lambda Light chain antibody (AB4211)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - FITC Anti-Lambda Light chain antibody (AB4211)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of Human tonsil tissue labeling Lambda Light chain with ab4211.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Conjugation

FITC

Excitation/Emission

Ex: 495nm, Em: 519nm

Carrier free

Reacts with

Human

Applications

IHC-P

applications

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/40", "IHCP-species-notes": "<p>Pretreat tissue with Proteinase K for 30 minutes at 37°C. Incubate with primary antibody for 30-60 minutes at room temperature.</p>" } } }

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Properties and storage information

Form

Liquid

Purity

IgG fraction

Purification notes

Traces of contaminating antibodies have been removed by solid phase absorption. Only the lambda precipitation line appeared in cross immunoelectrophoresis.

Storage buffer

pH: 7.3 - 7.5 Preservative: 0.05% Sodium azide Constituents: 1% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

+4°C

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Lambda Light Chain also known as lambda chain or lambda protein forms a part of immunoglobulins (antibodies). Its mass typically ranges between 22 to 24 kDa. This protein is expressed primarily in B cells. Specifically it pairs with heavy chains to form the complete antibody molecule. It participates in the antigen recognition process supporting the immune system's defense mechanisms.

Biological function summary

Lambda Light Chain participates in immunological functions by contributing to the antigen-binding site of antibodies. It exists as a part of the immunoglobulin complex. The lambda chain alongside heavy chains forms the variable part of antibodies allowing specificity in antigen recognition. Its variation leads to a diverse antibody repertoire which is important for recognizing a wide range of pathogens.

Pathways

Lambda Light Chain fits into pathways involving adaptive immune responses. It is important in antigen processing and presentation pathways. In this context it interacts with the heavy chains which together drive the specificity and efficiency of immune response pathways. It also associates with proteins like the major histocompatibility complex (MHC) which facilitates antigen presentation to T cells.

Lambda Light Chain associates with multiple myeloma a cancer of plasma cells and light chain amyloidosis a disorder where light chains accumulate as amyloid fibrils in tissues. In these conditions proteins like immunoglobulin heavy chain and albumin often interact with or are affected by lambda chains providing insights into disease mechanisms and potential targets for therapeutic intervention.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

See full target information Lambda Light chain

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cancer letters : PubMed33556544

2021

DIM-C-pPhtBu induces lysosomal dysfunction and unfolded protein response -mediated cell death via excessive mitophagy.

Applications

Unspecified application

Species

Unspecified reactive species

Sung Un Kang,Dae Ho Kim,Yun Sang Lee,Mei Huang,Hyung Kwon Byeon,Seong-Ho Lee,Seung Joon Baek,Chul-Ho Kim

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

FITC Anti-Lambda Light chain antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - FITC Anti-Lambda Light chain antibody (AB4211)

Key facts

Host species

Clonality

Isotype

Conjugation

Excitation/Emission

Carrier free

Reacts with

Applications

Reactivity data

Properties and storage information

Form

Purity

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

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