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Mouse Monoclonal Mannose Receptor antibody - conjugated to FITC. Suitable for Flow Cyt and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Native Full Length Protein corresponding to Human MRC1.

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Images

Flow Cytometry - FITC Anti-Mannose Receptor antibody [15-2] (AB270647), expandable thumbnail
  • Flow Cytometry - FITC Anti-Mannose Receptor antibody [15-2] (AB270647), expandable thumbnail
  • Flow Cytometry - FITC Anti-Mannose Receptor antibody [15-2] (AB270647), expandable thumbnail

Publications

Key facts

Isotype

IgG1

Host species

Mouse

Conjugation

FITC

Excitation/Emission

Ex: 495nm, Em: 519nm

Storage buffer

pH: 7.4
Preservative: 0.1% Sodium azide
Constituents: PBS

Form

Liquid

Clonality

Monoclonal

Immunogen

  • Native Full Length Protein corresponding to Human MRC1. Database link P22897

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
Flow Cyt
Human
Tested

Tested
Tested

Species

Human

Dilution info

4 µL for 106 Cells

Notes

-

Associated Products

Select an associated product type

2 products for Alternative Version

Target data

Function

Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains.(Microbial infection) Acts as a phagocytic receptor for bacteria, fungi and other pathogens.(Microbial infection) Acts as a receptor for Dengue virus envelope protein E.(Microbial infection) Interacts with Hepatitis B virus envelope protein.

Alternative names

Recommended products

Mouse Monoclonal Mannose Receptor antibody - conjugated to FITC. Suitable for Flow Cyt and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Native Full Length Protein corresponding to Human MRC1.

Key facts

Isotype

IgG1

Conjugation

FITC

Excitation/Emission

Ex: 495nm, Em: 519nm

Form

Liquid

Clonality

Monoclonal

Immunogen
  • Native Full Length Protein corresponding to Human MRC1. Database link P22897
Clone number

15-2

Purification technique

Size-exclusion chromatography

Light chain type

kappa

Concentration
Loading...

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

+4°C

Storage information

Store in the dark

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The Mannose Receptor also known as CD206 or MRC1 is a type of C-type lectin receptor with a molecular weight of 175 kDa. It is expressed on the surface of macrophages and dendritic cells. This receptor binds to complex carbohydrates like mannose and fucose found on pathogen surfaces playing an important role in their recognition. Mannose Receptors act as endocytic receptors aiding in the internalization and degradation of pathogens.

Biological function summary

The Mannose Receptor functions in pathogen recognition and clearance by binding to specific carbohydrates on the pathogen's surface. It is not part of a larger molecular complex but works independently to facilitate phagocytosis. The receptor is essential in immune responses allowing macrophages and dendritic cells to efficiently capture and process antigens for presentation to T cells. This enables the initiation of adaptive immune responses.

Pathways

Researchers know that the Mannose Receptor plays an important role in immune signaling pathways particularly in antigen processing and presentation. It interacts with proteins involved in these pathways including those necessary for the internalization and degradation of bound antigens. Moreover it works alongside scavenger receptors contributing to the regulation of immune and inflammatory responses.

Associated diseases and disorders

The Mannose Receptor is often linked to pulmonary tuberculosis and certain types of cancer. When macrophages express this receptor it can modulate immune responses against Mycobacterium tuberculosis by aiding in its recognition. In cancer altered expression of CD206 can indicate tumor-associated macrophages which promote tumor growth by suppressing immune responses. These connections highlight the receptor's potential as a diagnostic marker and therapeutic target.

Product promise

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In the unlikely event of one of our products not working as expected, you are covered by our product promise.

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3 product images

  • Flow Cytometry - FITC Anti-Mannose Receptor antibody [15-2] (ab270647), expandable thumbnail

    Flow Cytometry - FITC Anti-Mannose Receptor antibody [15-2] (ab270647)

    Flow cytometry analysis of dendritic cells differentiated upon monocyte stimulation (GM-CSF + IL-4) (red) and non-stimulated lymphocytes (black) cells labeling Mannose Receptor using ab270647. Concentration of 4 μl reagent/100μl peripheral whole blood.

  • Flow Cytometry - FITC Anti-Mannose Receptor antibody [15-2] (ab270647), expandable thumbnail

    Flow Cytometry - FITC Anti-Mannose Receptor antibody [15-2] (ab270647)

    Flow cytometry multicolour surface staining analysis of human stimulated monocytes (GM-CSF + IL-4) cells labeling Mannose Receptor using ab270647. Concentration of 4 μl reagent per milion cells in 100μl of cell suspension.

  • Flow Cytometry - FITC Anti-Mannose Receptor antibody [15-2] (ab270647), expandable thumbnail

    Flow Cytometry - FITC Anti-Mannose Receptor antibody [15-2] (ab270647)

    Flow cytometry analysis of human stimulated monocytes cells labeling Mannose Receptor using ab270647. Concentration of 4 μl reagent per milion cells 100μl of cell suspension.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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