AB270647

FITC Anti-Mannose Receptor antibody [15-2]

Name: Anti-Mannose Receptor FITC antibody [15-2] (ab270647) IgG1 | Abcam
Brand: Abcam Limited
SKU: AB270647
Price: 120 USD
Availability: InStock

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(16 Publications)

Mouse Monoclonal Mannose Receptor antibody - conjugated to FITC. Suitable for Flow Cyt and reacts with Human samples. Cited in 16 publications. Immunogen corresponding to Native Full Length Protein corresponding to Human MRC1.

View Alternative Names

CD206, CLEC13D, CLEC13DL, MRC1L1, MRC1, Macrophage mannose receptor 1, MMR, C-type lectin domain family 13 member D, C-type lectin domain family 13 member D-like, Human mannose receptor, Macrophage mannose receptor 1-like protein 1, hMR

3 Images

Flow Cytometry - FITC Anti-Mannose Receptor antibody [15-2] (AB270647)

Flow Cyt

Supplier Data

Flow Cytometry - FITC Anti-Mannose Receptor antibody [15-2] (AB270647)

Flow cytometry analysis of human stimulated monocytes cells labeling Mannose Receptor using ab270647. Concentration of 4 μl reagent per milion cells 100μl of cell suspension.

Flow Cyt

Supplier Data

Flow Cytometry - FITC Anti-Mannose Receptor antibody [15-2] (AB270647)

Flow cytometry analysis of dendritic cells differentiated upon monocyte stimulation (GM-CSF + IL-4) (red) and non-stimulated lymphocytes (black) cells labeling Mannose Receptor using ab270647. Concentration of 4 μl reagent/100μl peripheral whole blood.

Flow Cyt

Supplier Data

Flow Cytometry - FITC Anti-Mannose Receptor antibody [15-2] (AB270647)

Flow cytometry multicolour surface staining analysis of human stimulated monocytes (GM-CSF + IL-4) cells labeling Mannose Receptor using ab270647. Concentration of 4 μl reagent per milion cells in 100μl of cell suspension.

Unconjugated

Anti-Mannose Receptor antibody [15-2]
695 PerCP/Cy5.5®

PerCP/Cy5.5® Anti-Mannose Receptor antibody [15-2]
778 PE/Cy7®

PE/Cy7® Anti-Mannose Receptor antibody [15-2]

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

15-2

Isotype

IgG1

Light chain type

kappa

Conjugation

FITC

Excitation/Emission

Ex: 495nm, Em: 519nm

Carrier free

Reacts with

Human

Applications

Flow Cyt

applications

Immunogen

Native Full Length Protein corresponding to Human MRC1.

P22897

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "4 µL for 10^6 Cells", "FlowCyt-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Size-exclusion chromatography

Storage buffer

pH: 7.4 Preservative: 0.1% Sodium azide Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

+4°C

Storage information

Store in the dark

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Mannose Receptor also known as CD206 or MRC1 is a type of C-type lectin receptor with a molecular weight of 175 kDa. It is expressed on the surface of macrophages and dendritic cells. This receptor binds to complex carbohydrates like mannose and fucose found on pathogen surfaces playing an important role in their recognition. Mannose Receptors act as endocytic receptors aiding in the internalization and degradation of pathogens.

Biological function summary

The Mannose Receptor functions in pathogen recognition and clearance by binding to specific carbohydrates on the pathogen's surface. It is not part of a larger molecular complex but works independently to facilitate phagocytosis. The receptor is essential in immune responses allowing macrophages and dendritic cells to efficiently capture and process antigens for presentation to T cells. This enables the initiation of adaptive immune responses.

Pathways

Researchers know that the Mannose Receptor plays an important role in immune signaling pathways particularly in antigen processing and presentation. It interacts with proteins involved in these pathways including those necessary for the internalization and degradation of bound antigens. Moreover it works alongside scavenger receptors contributing to the regulation of immune and inflammatory responses.

The Mannose Receptor is often linked to pulmonary tuberculosis and certain types of cancer. When macrophages express this receptor it can modulate immune responses against Mycobacterium tuberculosis by aiding in its recognition. In cancer altered expression of CD206 can indicate tumor-associated macrophages which promote tumor growth by suppressing immune responses. These connections highlight the receptor's potential as a diagnostic marker and therapeutic target.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains.. (Microbial infection) Acts as a phagocytic receptor for bacteria, fungi and other pathogens.. (Microbial infection) Acts as a receptor for Dengue virus envelope protein E.. (Microbial infection) Interacts with Hepatitis B virus envelope protein.

See full target information MRC1

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Publications (16)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 15:25065 PubMed40645977

2025

Construction of a macrophage-related prognostic signature and assessment of immune checkpoint inhibitor efficacy of HCC.

Applications

Unspecified application

Species

Unspecified reactive species

Shouge Zang,Hongwei Chen,Yuqian Han,Di Cui,Jiangtao Yu

Scientific reports 15:20507 PubMed40592997

2025

Sphingosine 1-phosphate derived from tumor-educated hepatic stellate cells combining with S1PR4 promotes tumor associated macrophages differentiation through FAO modulation.

Applications

Unspecified application

Species

Unspecified reactive species

Rui Feng,Zilin Cui,Long Yang,Zirong Liu

Journal of orthopaedic surgery and research 20:336 PubMed40176111

2025

USP15-modified ADMSCs-Exo alleviates chondrocyte damage and effectively relieved osteoarthritis by inducing M2 polarization of macrophages through deubiquitinating FOXC1.

Applications

Unspecified application

Species

Unspecified reactive species

Qibin Liang,Qinghe Ding,Liang Zhao,Jingchao Tan,Wei Niu

Cancer cell international 25:95 PubMed40089803

2025

ZEB1 promotes the immune escape of ovarian cancer through the MCSF-CCL18 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Yan-Ping Jin,Guo-Wei Li,Qian-Qian Xu,Xiao-Lan Wang

Molecular medicine reports 31: PubMed40052573

2025

N‑methyladenosine reader YTHDF2‑mediated AC026691.1 degradation promotes gastric cancer cell proliferation, migration and M2 macrophage polarization.

Applications

Unspecified application

Species

Unspecified reactive species

Cong-Fei Ji,Jin-Feng Ji,Xiao-Bing Yu,Zhen-Xin Wang

European journal of medical research 30:12 PubMed39773303

2025

GATA1-mediated macrophage polarization via TrkB/cGMP-PKG signaling pathway to promote the development of preeclampsia.

Applications

Unspecified application

Species

Unspecified reactive species

Wushan Li,Fei Hou,Di Cheng,Fengchun Gao,Jin Wang,Baoxia Cui

Journal of biochemical and molecular toxicology 38:e23707 PubMed38622979

2024

M2 macrophage-derived paracrine factor TNFSF13 affects the fibrogenic alterations in endothelial cells and cardiac fibroblasts by mediating the NF-κB and Akt pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaoli Tan,Jintang Wang,Xiangyang Liu,Genyuan Xie,Fan Ouyang

Thoracic cancer 15:227-238 PubMed38087801

2023

Tumor-related exosomal circ_0001715 promotes lung adenocarcinoma cell proliferation and metastasis via enhancing M2 macrophage polarization by regulating triggering receptor expressed on myeloid cells-2.

Applications

Unspecified application

Species

Unspecified reactive species

Mengjun Chen,Chengzhang Cao,Jun Ma

Chinese medicine 18:143 PubMed37919806

2023

Xinyang tablet ameliorates sepsis-induced myocardial dysfunction by regulating Beclin-1 to mediate macrophage autophagy and M2 polarization through LncSICRNT1 targeting E3 ubiquitin ligase TRAF6.

Applications

Unspecified application

Species

Unspecified reactive species

Yuanyuan Luo,Yuanmei Li,Liwei He,Haitao Tu,Xinfeng Lin,Fengli Zhao,Yusheng Huang,Minyong Wen,Lingjun Wang,Zhongqi Yang

Heliyon 9:e19934 PubMed37809369

2023

BMP-7 modified exosomes derived from synovial mesenchymal stem cells attenuate osteoarthritis by M2 polarization of macrophages.

Applications

Unspecified application

Species

Unspecified reactive species

Weixue Sun,Shaozheng Qu,Mingxia Ji,Yanli Sun,Baiqiang Hu

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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FITC Anti-Mannose Receptor antibody [15-2]

Flow Cytometry - FITC Anti-Mannose Receptor antibody [15-2] (AB270647)

Flow Cytometry - FITC Anti-Mannose Receptor antibody [15-2] (AB270647)

Flow Cytometry - FITC Anti-Mannose Receptor antibody [15-2] (AB270647)

Related conjugates and formulations (3)

Key facts

Host species

Clonality

Clone number

Isotype

Light chain type

Conjugation

Excitation/Emission

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (16)

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