FITC Anti-Treponema pallidum antibody

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

The spirochete bacterium causes systemic infection and can invade multiple organs and systems. As part of a highly invasive entity Treponema pallidum can penetrate the endothelium and interact with host cells promoting persistent infection. It lacks numerous enzymes found in other bacteria which makes it dependent on the host for nutrients complicating its study. The bacterium is adept at avoiding the immune system partly due to its limited surface proteins that are targeted by host defenses.

Pathways

The interaction of Treponema pallidum with host immune pathways involves critical interference with host-pathogen interactions. It affects pathways related to immune evasion influencing the complement system and cytokine signaling. The bacterium influences other proteins like those regulating immune responses resulting in altered host immune functionalities. It exploits these pathways to promote survival and successful infection within the host.